2015
Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations
Arout CA, Edens E, Petrakis IL, Sofuoglu M. Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations. CNS Drugs 2015, 29: 465-486. PMID: 26142224, DOI: 10.1007/s40263-015-0255-x.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaClinical treatmentChronic painEfficacious treatment regimenTreatment of painOpioid-dependent individualsOpioid-related overdosesAminobutyric acid receptorsDeleterious profileProspective adjuvantOpioid prescriptionsSevere painOpioid analgesicsTreatment regimenNeuroimmune systemPainful stimuliSide effectsLong-term exposurePainAcid receptorsOpioidsClinical usePotential modulatorsHyperalgesiaParadoxical state
2009
Novel Pharmacological Approaches to Drug Abuse Treatment
Edens E, Massa A, Petrakis I. Novel Pharmacological Approaches to Drug Abuse Treatment. Current Topics In Behavioral Neurosciences 2009, 3: 343-386. PMID: 21161760, DOI: 10.1007/7854_2009_29.Peer-Reviewed Original ResearchConceptsNovel pharmacological approachesPharmacological approachesAddiction treatmentDrug abuse treatmentDrugs of abuseWithdrawal discomfortDopaminergic tonePharmacologic researchRewarding effectsNeural pathwaysAbuse treatmentNeurobiological underpinningsTreatmentNicotineDrugsVaried treatmentsAdditional substancesComorbiditiesMedicationsOpiates