Featured Publications
In the balance: No new diagnosis needed in addition to opioid use disorder to study harms associated with long‐term opioid therapy
Drexler K, Edens E, Trafton J, Compton W. In the balance: No new diagnosis needed in addition to opioid use disorder to study harms associated with long‐term opioid therapy. Addiction 2023, 119: 6-8. PMID: 37766392, DOI: 10.1111/add.16349.Peer-Reviewed Original ResearchThe Use of Opioids in the Management of Chronic Pain.
Sall J, Sandbrink F, Murphy J, Spevak C, Edens E. The Use of Opioids in the Management of Chronic Pain. Annals Of Internal Medicine 2023, 176: el230225. PMID: 37722120, DOI: 10.7326/l23-0225.Peer-Reviewed Original ResearchThe Use of Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.
Sandbrink F, Murphy J, Johansson M, Olson J, Edens E, Clinton-Lont J, Sall J, Spevak C, Sandbrink F, Murphy J, Johansson M, Spevak C, Clinton-Lont J, MD E, Olson J, Brown N, Guinta R, Macedo F, Nazario M, Pangarkar S, Preston S, Prince M, Real D, Riegleman D, Steil E, Institute E, Group L, Consulting S. The Use of Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline. Annals Of Internal Medicine 2023, 176: 388-397. PMID: 36780654, DOI: 10.7326/m22-2917.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidChronic PainHumansUnited StatesUnited States Department of Veterans AffairsVeteransConceptsClinical practice guidelinesUse of opioidsChronic painOpioid therapyPractice guidelinesGuideline teamVeterans AffairsVA/DOD Clinical Practice GuidelineDefense Clinical Practice GuidelineJoint clinical practice guidelineVA/DoD EvidenceTrustworthy clinical practice guidelinesFull agonist opioidsGuideline development teamsPractice Work GroupUse of buprenorphineBehavioral health conditionsUse of painSystematic evidence reviewMedicine's tenetsPostsurgical painAgonist opioidsOpioid useOpioid educationHigh risk
2024
How Should the Use of Opioids Be Regulated to Motivate Better Clinical Practice?
Edens E, Garcia Vassallo G, Heimer R. How Should the Use of Opioids Be Regulated to Motivate Better Clinical Practice? The AMA Journal Of Ethic 2024, 26: e551-561. PMID: 38958424, DOI: 10.1001/amajethics.2024.551.Peer-Reviewed Original ResearchConceptsTreat opioid use disorderOpioid use disorderPrescribed long-term opioid therapyLong-term opioid therapyOpioid prescribing policiesOpioid therapyPrescribed opioidsOpioid prescribingUse disorderOpioidClinical practicePainPrescribing policiesDiagnostic categoriesClinical frameworkPrescribingPolitical reasonsTherapy
2023
Perioperative Management of Extended-Release Buprenorphine: A Narrative Review and Case Series
Hickey T, Meeks T, Oxentine H, Park D, Abelleira A, Edens E, Gordon A, Acampora G. Perioperative Management of Extended-Release Buprenorphine: A Narrative Review and Case Series. Substance Abuse 2023, 44: 96-103. PMID: 37226900, DOI: 10.1177/08897077231167043.Peer-Reviewed Original ResearchConceptsExtended-release buprenorphinePerioperative managementPerioperative experienceNarrative reviewOutpatient inguinal hernia repairFull agonist opioidsSeries of patientsOpioid use disorderCases of patientsCommon clinical challengeInguinal hernia repairVariety of surgeriesDifferent medical centersDisorder treatment providersNationwide healthcare systemMultimodal analgesiaAgonist opioidsCase seriesBuprenorphine formulationsInpatient surgeryCase reportProspective dataClinical dataHernia repairClinical challenge
2022
Perioperative Management of Extended-release Buprenorphine
Hickey TR, Henry JT, Edens EL, Gordon AJ, Acampora G. Perioperative Management of Extended-release Buprenorphine. Journal Of Addiction Medicine 2022, 17: e67-e71. PMID: 35862898, DOI: 10.1097/adm.0000000000001024.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineDelayed-Action PreparationsHumansOpioid-Related DisordersPainPain Management
2021
Optimizing Interdisciplinary Virtual Pain Care and Buprenorphine Initiation During COVID-19: A Quality Improvement Study
Edmond SN, Currie S, Gehrke A, Falker CG, Sung M, Abelleira A, Edens EL, Becker WC. Optimizing Interdisciplinary Virtual Pain Care and Buprenorphine Initiation During COVID-19: A Quality Improvement Study. Pain Medicine 2021, 23: 1043-1046. PMID: 34940877, PMCID: PMC9383145, DOI: 10.1093/pm/pnab348.Peer-Reviewed Original ResearchManagement of Adolescents With OUD: A Simulation Case for Subspecialty Trainees in Addiction Medicine and Addiction Psychiatry
Garcia-Vassallo G, Edens EL, Heward B, Auerbach MA, Wong AH, Camenga D. Management of Adolescents With OUD: A Simulation Case for Subspecialty Trainees in Addiction Medicine and Addiction Psychiatry. MedEdPORTAL 2021, 17: 11147. PMID: 33889724, PMCID: PMC8056775, DOI: 10.15766/mep_2374-8265.11147.Peer-Reviewed Original ResearchMeSH KeywordsAddiction MedicineAdolescentAnalgesics, OpioidCurriculumEducation, MedicalFemaleHumansMaleOpioid-Related DisordersConceptsOpioid use disorderSimulation-based educational interventionClinical Opiate Withdrawal ScaleSymptoms of opioid withdrawalOpiate Withdrawal ScaleEducational interventionWithdrawal ScaleUse disorderOpioid withdrawalTreating adolescentsConfidence surveyTrainee confidenceAddiction medicineMedical treatment optionsAssess symptomsMedication treatment optionsQuality health careManagement of adolescentsParticipants' reportsEvaluating adolescentsMedical education curriculumAdolescentsIncrease trainees' confidenceAddictionTreatment options
2020
Switching From High-Dose, Long-Term Opioids to Buprenorphine: A Case Series.
Becker WC, Frank JW, Edens EL. Switching From High-Dose, Long-Term Opioids to Buprenorphine: A Case Series. Annals Of Internal Medicine 2020, 173: 70-71. PMID: 32252072, DOI: 10.7326/l19-0725.Peer-Reviewed Original Research
2018
Multimodal Treatment Options, Including Rotating to Buprenorphine, Within a Multidisciplinary Pain Clinic for Patients on Risky Opioid Regimens: A Quality Improvement Study
Oldfield BJ, Edens EL, Agnoli A, Bone CW, Cervone DJ, Edmond SN, Manhapra A, Sellinger JJ, Becker WC. Multimodal Treatment Options, Including Rotating to Buprenorphine, Within a Multidisciplinary Pain Clinic for Patients on Risky Opioid Regimens: A Quality Improvement Study. Pain Medicine 2018, 19: s38-s45. PMID: 30203007, DOI: 10.1093/pm/pny086.Peer-Reviewed Original ResearchConceptsPrimary care providersIntake appointmentMorphine equivalent daily dosePartial opioid agonist buprenorphineVeterans Health Administration hospitalsPartial agonist therapiesPrescribed opioid dosesRetrospective cohort studyUnsafe useEquivalent daily doseMultidisciplinary pain clinicMultimodal treatment optionsChronic pain managementPrimary care settingQuality improvement studyHealth system levelHealth system improvementOpioid dosesCohort studyPain clinicDaily doseOpioid regimensPain managementMultidisciplinary clinicTreatment options
2017
Patient and Public Safety Maximized by Rapid Opioid Taper—Reply
Guillod P, Edens EL, Becker WC. Patient and Public Safety Maximized by Rapid Opioid Taper—Reply. JAMA Internal Medicine 2017, 177: 896-896. PMID: 28586812, DOI: 10.1001/jamainternmed.2017.1454.Peer-Reviewed Original ResearchEvaluation of an Integrated, Multidisciplinary Program to Address Unsafe Use of Opioids Prescribed for Pain
Becker WC, Edmond SN, Cervone DJ, Manhapra A, Sellinger JJ, Moore BA, Edens EL. Evaluation of an Integrated, Multidisciplinary Program to Address Unsafe Use of Opioids Prescribed for Pain. Pain Medicine 2017, 19: 1419-1424. PMID: 28371816, DOI: 10.1093/pm/pnx041.Peer-Reviewed Original ResearchConceptsPreliminary efficacyUnsafe useSubstance abuse/dependenceMultidisciplinary care teamSubstance use disorder diagnosisPrimary care physiciansAdvanced practice nursesUrine drug testingLength of treatmentStructured clinical assessmentNurse case managersAbuse/dependenceHealth system levelHigh-complexity patientsElectronic progress notesOpioid prescribedOpioid receiptCare physiciansPractice nursesPrimary careCare coordinationCare teamClinical assessmentCare modelClinic processesUltra–High-Dose Opioids With Low Efficacy and Significant Harm—Time to Make a Change: A Teachable Moment
Guillod P, Edens EL, Becker WC. Ultra–High-Dose Opioids With Low Efficacy and Significant Harm—Time to Make a Change: A Teachable Moment. JAMA Internal Medicine 2017, 177: 17-18. PMID: 27893881, DOI: 10.1001/jamainternmed.2016.7344.Peer-Reviewed Original Research
2016
Management of patients with issues related to opioid safety, efficacy and/or misuse: a case series from an integrated, interdisciplinary clinic
Becker WC, Merlin JS, Manhapra A, Edens EL. Management of patients with issues related to opioid safety, efficacy and/or misuse: a case series from an integrated, interdisciplinary clinic. Addiction Science & Clinical Practice 2016, 11: 3. PMID: 26818474, PMCID: PMC4730605, DOI: 10.1186/s13722-016-0050-0.Peer-Reviewed Original ResearchConceptsChronic painOpioid safetyInterdisciplinary clinicClinical scenariosCo-occurring chronic painMultimodal pain careManagement of patientsOpioid use disorderTreatment of patientsLack of efficacySimilar clinical scenariosComplex clinical scenariosQuality of careHazardous alcohol useSubstance abuse treatmentOpioid treatmentBuprenorphine/Case seriesPain careMultimodal treatmentClinical equipoisePrimary careUse disordersPainPatients
2015
Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations
Arout CA, Edens E, Petrakis IL, Sofuoglu M. Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations. CNS Drugs 2015, 29: 465-486. PMID: 26142224, DOI: 10.1007/s40263-015-0255-x.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaClinical treatmentChronic painEfficacious treatment regimenTreatment of painOpioid-dependent individualsOpioid-related overdosesAminobutyric acid receptorsDeleterious profileProspective adjuvantOpioid prescriptionsSevere painOpioid analgesicsTreatment regimenNeuroimmune systemPainful stimuliSide effectsLong-term exposurePainAcid receptorsOpioidsClinical usePotential modulatorsHyperalgesiaParadoxical state