Featured Publications
The Use of Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.
Sandbrink F, Murphy J, Johansson M, Olson J, Edens E, Clinton-Lont J, Sall J, Spevak C, Sandbrink F, Murphy J, Johansson M, Spevak C, Clinton-Lont J, MD E, Olson J, Brown N, Guinta R, Macedo F, Nazario M, Pangarkar S, Preston S, Prince M, Real D, Riegleman D, Steil E, Institute E, Group L, Consulting S. The Use of Opioids in the Management of Chronic Pain: Synopsis of the 2022 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline. Annals Of Internal Medicine 2023, 176: 388-397. PMID: 36780654, DOI: 10.7326/m22-2917.Peer-Reviewed Original ResearchConceptsClinical practice guidelinesUse of opioidsChronic painOpioid therapyPractice guidelinesGuideline teamVeterans AffairsVA/DOD Clinical Practice GuidelineDefense Clinical Practice GuidelineJoint clinical practice guidelineVA/DoD EvidenceTrustworthy clinical practice guidelinesFull agonist opioidsGuideline development teamsPractice Work GroupUse of buprenorphineBehavioral health conditionsUse of painSystematic evidence reviewMedicine's tenetsPostsurgical painAgonist opioidsOpioid useOpioid educationHigh riskAddiction and Chronic Pain: Training Addiction Psychiatrists
Edens EL, Gafni I, Encandela J. Addiction and Chronic Pain: Training Addiction Psychiatrists. Academic Psychiatry 2015, 40: 489-493. PMID: 26626792, DOI: 10.1007/s40596-015-0412-z.Peer-Reviewed Original Research
2023
Increasing buprenorphine access for patients with chronic pain: a quality improvement initiative
Wesolowicz D, Spelman J, Edmond S, Schwartz A, Kravetz J, Edens E, Becker W. Increasing buprenorphine access for patients with chronic pain: a quality improvement initiative. Pain Medicine 2023, 25: 226-230. PMID: 37847654, DOI: 10.1093/pm/pnad140.Peer-Reviewed Original ResearchQuality improvement initiativesSpecialty pain clinicPrimary care providersPrimary careChronic painPain clinicCare providersImprovement initiativesVeterans Health Administration healthcare systemFull agonist opioidsPrimary care clinicsNumber of patientsEligible patientsBuprenorphine prescribingCare clinicsPain careProvider comfortStandard operating proceduresBuprenorphine accessBuprenorphinePainPrescribingPatientsEducational sessionsClinic
2016
Management of patients with issues related to opioid safety, efficacy and/or misuse: a case series from an integrated, interdisciplinary clinic
Becker WC, Merlin JS, Manhapra A, Edens EL. Management of patients with issues related to opioid safety, efficacy and/or misuse: a case series from an integrated, interdisciplinary clinic. Addiction Science & Clinical Practice 2016, 11: 3. PMID: 26818474, PMCID: PMC4730605, DOI: 10.1186/s13722-016-0050-0.Peer-Reviewed Original ResearchConceptsChronic painOpioid safetyInterdisciplinary clinicClinical scenariosCo-occurring chronic painMultimodal pain careManagement of patientsOpioid use disorderTreatment of patientsLack of efficacySimilar clinical scenariosComplex clinical scenariosQuality of careHazardous alcohol useSubstance abuse treatmentOpioid treatmentBuprenorphine/Case seriesPain careMultimodal treatmentClinical equipoisePrimary careUse disordersPainPatients
2015
Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations
Arout CA, Edens E, Petrakis IL, Sofuoglu M. Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations. CNS Drugs 2015, 29: 465-486. PMID: 26142224, DOI: 10.1007/s40263-015-0255-x.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaClinical treatmentChronic painEfficacious treatment regimenTreatment of painOpioid-dependent individualsOpioid-related overdosesAminobutyric acid receptorsDeleterious profileProspective adjuvantOpioid prescriptionsSevere painOpioid analgesicsTreatment regimenNeuroimmune systemPainful stimuliSide effectsLong-term exposurePainAcid receptorsOpioidsClinical usePotential modulatorsHyperalgesiaParadoxical state