Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia
Saftlas A, Rubenstein L, Prater K, Harland K, Field E, Triche E. Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia. Journal Of Reproductive Immunology 2013, 101: 104-110. PMID: 24011785, DOI: 10.1016/j.jri.2013.07.006.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaVaginal exposureNulliparous womenImmune maladaptation hypothesisOdds of preeclampsiaMedical chart reviewPercentile of exposureBarrier contraceptive methodsCase-control studyVaginal sexual intercourseAllogeneic fetusChart reviewIowa womenPaternal HLAAntigen exposureImmune toleranceNormotensive controlsPaternal antigensMaternal tolerancePreeclampsia casesPreeclampsia riskSubsequent riskSeminal fluidLive birthsContraceptive use