2024
Network state dynamics underpin basal craving in a transdiagnostic population
Ye J, Garrison K, Lacadie C, Potenza M, Sinha R, Goldfarb E, Scheinost D. Network state dynamics underpin basal craving in a transdiagnostic population. Molecular Psychiatry 2024, 1-10. PMID: 39183336, DOI: 10.1038/s41380-024-02708-0.Peer-Reviewed Original ResearchConnectome-based predictive modelingBrain responsesRegulation of affective statesSample of healthy controlsTransdiagnostic populationTransdiagnostic sampleHigher cravingMotivational stateCravingFMRI methodsAffective statesScan runsExperimental stimuliNetwork engagementBrain dynamicsClinical implicationsHealthy controlsBrainIndividual variationState dynamicsCharacterize individualsReplication datasetPsychopathologyFMRIEngagementDrawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking
Harris B, Sinha R, Goldfarb E. Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking. Journal Of Neuroscience 2024, 44: e1027242024. PMID: 39147591, PMCID: PMC11450530, DOI: 10.1523/jneurosci.1027-24.2024.Peer-Reviewed Original ResearchAlcohol motivationInfluence later behaviorEnhance memorySalience responseFemale social drinkersAlcohol drinkingEmotionally salient experiencesResponse to alcoholDouble-blind cross-over designMemory biasSalient memoriesAlcohol-related eventsRisky alcohol drinkingSocial drinkersMotivated behaviorMaladaptive consequencesLateral behaviorCross-over designRisky drinkingMemoryRodent modelsHuman researchSalienceRisky drinkersCortisolAcute Stress Effects on Statistical Learning and Episodic Memory
Sherman B, Huang I, Wijaya E, Turk-Browne N, Goldfarb E. Acute Stress Effects on Statistical Learning and Episodic Memory. Journal Of Cognitive Neuroscience 2024, 36: 1741-1759. PMID: 38713878, PMCID: PMC11223726, DOI: 10.1162/jocn_a_02178.Peer-Reviewed Original ResearchEpisodic memoryAcute stressStatistical learningEffects of acute stressStress-induced cortisol levelsImpaired episodic memoryModulate learning processesAcute stress effectsImpact hippocampal functionEpisodic encodingRodent workEvidence of learningHippocampal functionStress effectsHippocampal pathwaysLearning tasksBehavioral experimentsPreliminary evidenceCortisol levelsNo stressMemoryMultiple measuresHippocampusScene categoriesParticipantsIntegrating and fragmenting memories under stress and alcohol
Loetscher K, Goldfarb E. Integrating and fragmenting memories under stress and alcohol. Neurobiology Of Stress 2024, 30: 100615. PMID: 38375503, PMCID: PMC10874731, DOI: 10.1016/j.ynstr.2024.100615.Peer-Reviewed Original ResearchMemory representationsMemory integrationMemory-guided behaviorPre-existing schemaEffects of alcoholMemory bindingAversive learningNegative affectCognitive mechanismsPreclinical findingsMemoryDesign appropriate interventionsIndividual experienceAppropriate interventionsFragmented memoryAlcoholCausal structureAffectBehaviorMultiple levelsFindingsRepresentationStressSchemaIntervention
2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient informationPerceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers
Kang S, Larrabee G, Nair S, Goldfarb E. Perceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers. Psychological Science 2023, 34: 1146-1162. PMID: 37682597, PMCID: PMC10985388, DOI: 10.1177/09567976231181516.Peer-Reviewed Original ResearchSurprise recognition memory testAlcohol-related associationsRecognition memory testAlcohol-related imagesRisky drinkingPerceptual generalizationMemory testPerceptual similarityRisky drinkersNovel situationsAdaptive behaviorMaladaptive responsesOnline experimentPast experienceRisky patternsOvergeneralizationDrinkersDrinkingParticipantsConditioningIndividualsOutcomesExperienceAlcoholBiasAcute Stress Enhances Memory and Preference for Smoking-Related Associations in Smokers
Lee J, Kang S, Maier S, Lee S, Goldfarb E, Ahn W. Acute Stress Enhances Memory and Preference for Smoking-Related Associations in Smokers. Nicotine & Tobacco Research 2023, 26: 333-341. PMID: 37589502, DOI: 10.1093/ntr/ntad152.Peer-Reviewed Original ResearchSmoking-related itemsMemory biasesAcute stressNicotine dependenceAccuracy of memoryStress-induced relapseLaboratory-based stressorRole of stressMemory biasMemory recognitionContext memoryLaboratory paradigmContextual memoryVisual stimuliNicotine seekingAssociative memorySevere nicotine dependenceRewarding memoryMemoryControl conditionRelated contextGreater preferenceCurrent studyPotential interventionsItemsMultiple Memory Subsystems: Reconsidering Memory in the Mind and Brain
Sherman B, Turk-Browne N, Goldfarb E. Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain. Perspectives On Psychological Science 2023, 19: 103-125. PMID: 37390333, PMCID: PMC10756937, DOI: 10.1177/17456916231179146.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMemory representationsDistinct brain systemsLong-term memoryBrain structuresCross-species findingsSame brain structuresMemory-related structuresMemory researchBrain systemsMemory typesMemory organizationMemoryFuture researchOrganizational principlesClassic theoryMemory subsystemNovel perspectiveRepresentationAmygdalaResearchRecent workLearningMindTheoryDistinct typesBinge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake
Fan S, Goldfarb E, Lacadie C, Fogelman N, Seo D, Sinha R. Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake. Neurobiology Of Stress 2023, 25: 100540. PMID: 37323647, PMCID: PMC10265520, DOI: 10.1016/j.ynstr.2023.100540.Peer-Reviewed Original ResearchGray matter volumeDorsal lateral prefrontal cortexAlcohol use disorderSmaller gray matter volumeAlcohol intakePrefrontal gray matter volumeBinge drinkingFuture alcohol intakeMatter volumeBilateral dorsal lateral prefrontal cortexCortisol levelsStructural grey matter volumeHigher cortisolWhole-brain voxel-based morphometryAcute alcohol intakeLower gray matter volumeHigh-resolution structural MRIVoxel-based morphometryRegional gray matter volumePosterior parietal cortexMotor cortexSupplementary motorModerate drinkersUse disordersDrinking daysUnderstanding Posttraumatic Stress Disorder With Clues From the Dynamic Brain
Goldfarb E. Understanding Posttraumatic Stress Disorder With Clues From the Dynamic Brain. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 8: 345-346. PMID: 37028902, DOI: 10.1016/j.bpsc.2023.01.006.Peer-Reviewed Original Research
2022
High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks
Goldfarb EV, Scheinost D, Fogelman N, Seo D, Sinha R. High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 805-813. PMID: 35272096, PMCID: PMC9378362, DOI: 10.1016/j.bpsc.2022.02.010.Peer-Reviewed Original ResearchConceptsRisky drinkersHigh-risk drinkersBrain networksMajor public health problemExcessive alcohol intakeWhole-brain functional connectivityPublic health problemEarly preventive interventionsAlcohol use disorderDaily ecological momentary assessmentsAlcohol intakeControl subjectsRisky drinking behaviorsEmotional stress responsesUse disordersEarly markerHealth problemsPreventive interventionsBrain circuitryLight drinkersFunctional connectivityStress protocolHeavy drinkingDrinkersEcological momentary assessmentPolygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events
Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic eventsPolygenic scoringGreater emotional sensitivityChildhood neglect/abusePTSD symptom severityCertain traumatic eventsSevere PTSD symptomsPosttraumatic stress severityContext of traumaNeglect/abuseEarly life adversityHigher empathyPTSD symptomsEmotional sensitivityHigh empathizersStress disorderLife eventsEmpathyPotential traumaSymptom severityPolygenic scoresAutismStress severityDepression
2021
Elemental and configural threat learning bias extinction generalization
Goldfarb EV, Blow T, Dunsmoor JE, Phelps EA. Elemental and configural threat learning bias extinction generalization. Neurobiology Of Learning And Memory 2021, 180: 107405. PMID: 33609739, PMCID: PMC8076085, DOI: 10.1016/j.nlm.2021.107405.Peer-Reviewed Original ResearchConceptsExtinction generalizationCompound cueNegative emotional eventsTime of learningGroups of participantsMultitude of detailsThreat conditioningElemental learningAversive outcomesEmotional eventsExtinction strategiesExtinction taskAversive eventsEmotional experienceThreat responsesEmotional responsesAbsence of shockCuesMemorySingle representationParticipantsLearningToneImportant implicationsExtinction
2020
Participant stress in the COVID-19 era and beyond
Goldfarb EV. Participant stress in the COVID-19 era and beyond. Nature Reviews Neuroscience 2020, 21: 663-664. PMID: 32978609, PMCID: PMC7517748, DOI: 10.1038/s41583-020-00388-7.Peer-Reviewed Original ResearchHippocampal seed connectome-based modeling predicts the feeling of stress
Goldfarb EV, Rosenberg MD, Seo D, Constable RT, Sinha R. Hippocampal seed connectome-based modeling predicts the feeling of stress. Nature Communications 2020, 11: 2650. PMID: 32461583, PMCID: PMC7253445, DOI: 10.1038/s41467-020-16492-2.Peer-Reviewed Original ResearchMemory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes
Goldfarb EV, Fogelman N, Sinha R. Memory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes. Neuropsychopharmacology 2020, 45: 1297-1305. PMID: 32126569, PMCID: PMC7297955, DOI: 10.1038/s41386-020-0650-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAssociative memoryItem memoryMemory biasesUse disordersNovel memory taskAlcohol-related associationsDifferent memory systemsAlcohol useLater alcohol usePhotographs of objectsTreatment-seeking individualsTypes of memoryAlcohol use outcomesPrior drinking experienceReal-world behaviorMemory biasMemory taskNeutral scenesDetailed memoriesMemory testMaladaptive useHeavy alcohol useDrinking contextsDrinking experience
2019
Fighting the Return of Fear: Roles of Mindfulness-Based Stress Reduction and the Hippocampus
Goldfarb EV, Sinha R. Fighting the Return of Fear: Roles of Mindfulness-Based Stress Reduction and the Hippocampus. Biological Psychiatry 2019, 86: 652-653. PMID: 31601362, DOI: 10.1016/j.biopsych.2019.08.027.Peer-Reviewed Original ResearchSex differences in neural stress responses and correlation with subjective stress and stress regulation
Goldfarb EV, Seo D, Sinha R. Sex differences in neural stress responses and correlation with subjective stress and stress regulation. Neurobiology Of Stress 2019, 11: 100177. PMID: 31304198, PMCID: PMC6603439, DOI: 10.1016/j.ynstr.2019.100177.Peer-Reviewed Original ResearchAcute Stress Throughout the Memory Cycle: Diverging Effects on Associative and Item Memory
Goldfarb EV, Tompary A, Davachi L, Phelps EA. Acute Stress Throughout the Memory Cycle: Diverging Effects on Associative and Item Memory. Journal Of Experimental Psychology General 2019, 148: 13-29. PMID: 30221962, PMCID: PMC6312485, DOI: 10.1037/xge0000472.Peer-Reviewed Original ResearchConceptsItem memoryAssociative memoryAssociative recognition taskAcute stressForms of memoryStress-induced cortisolAcute stress effectsNeutral objectsNegative wordsRecognition taskSubjective arousalSubjects designMemoryItemsDifferent patternsArousalAssociativeWordsTaskParticipantsStress effectsRelationshipCortisolQuadratic relationshipKey differences
2018
Enhancing memory with stress: Progress, challenges, and opportunities
Goldfarb EV. Enhancing memory with stress: Progress, challenges, and opportunities. Brain And Cognition 2018, 133: 94-105. PMID: 30553573, PMCID: PMC9972486, DOI: 10.1016/j.bandc.2018.11.009.Peer-Reviewed Original ResearchConceptsLong-term memoryDeclarative memoryHippocampal-dependent memory processesMemory-related brain regionsHippocampus-dependent memoryMemory processesMemory functionRodent researchMemoryBrain regionsCentral stress responseFuture researchAcute stressPeripheral stress responsesStress effectsModulatory factorsRodent studiesPositive effectStress responseHuman studiesTranslational gapHumansResearchPhysiological mechanismsRodents