2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2017
Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus
Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, DeVito EE, Housden CR, Sahakian BJ, Pickard JD. Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus. PLOS ONE 2017, 12: e0181624. PMID: 28817574, PMCID: PMC5560677, DOI: 10.1371/journal.pone.0181624.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusWhite matter injuryDiffusion tensor imagingPressure hydrocephalusInternal capsulePosterior limbDTI measuresPatterns of injuryDifferent white matter tractsNon-invasive biomarkersWhite matter tractsInferior longitudinal fasciculusClinical outcomesInjury patternsNPH patientsEarly diagnosisLongitudinal fasciculusAxial diffusivityTensor imagingInjuryHydrocephalusPatientsImaging profileIndividual tractsTract
2015
Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus
Peterson KA, Housden CR, Killikelly C, DeVito EE, Keong NC, Savulich G, Czosnyka Z, Pickard JD, Sahakian BJ. Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus. British Journal Of Neurosurgery 2015, 30: 38-42. PMID: 25968325, DOI: 10.3109/02688697.2015.1029429.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusMini-Mental State ExaminationApathy Evaluation ScaleGeriatric Depression ScaleShunt surgeryApathetic symptomsPressure hydrocephalusBicaudate ratioSubcortical atrophyCaudate atrophyFunctional outcomeGDS scoresNeurocognitive improvementDepression ScaleCognitive recoveryLevel of apathyState ExaminationVentriculomegalySurgerySymptomsCognitive outcomesHydrocephalusAtrophyEvaluation ScaleGoal-directed behavior
2013
Gender differences in a clinical trial for prescription opioid dependence
McHugh RK, DeVito EE, Dodd D, Carroll KM, Potter JS, Greenfield SF, Connery HS, Weiss RD. Gender differences in a clinical trial for prescription opioid dependence. Journal Of Substance Use And Addiction Treatment 2013, 45: 38-43. PMID: 23313145, PMCID: PMC3626739, DOI: 10.1016/j.jsat.2012.12.007.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOpioid dependenceClinical trialsOpioid dependence severityPrescription drug dependenceLarge clinical trialsOpioid use outcomesGreater functional impairmentRoute of administrationSubstance use disordersGender differencesGreater psychiatric severityClinical characteristicsMedication doseStudy treatmentOpioid outcomesFunctional impairmentTreatment outcomesPre-treatment differencesPsychiatric severityTreatment retentionUse disordersLegitimate prescriptionDrug dependenceOpioids
2007
Caudate structural abnormalities in idiopathic normal pressure hydrocephalus
DeVito E, Salmond C, Owler B, Sahakian B, Pickard J. Caudate structural abnormalities in idiopathic normal pressure hydrocephalus. Acta Neurologica Scandinavica 2007, 116: 328-332. PMID: 17922726, DOI: 10.1111/j.1600-0404.2007.00906.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrophyBasal Ganglia DiseasesCaudate NucleusCerebrospinal Fluid PressureCorpus CallosumDisease ProgressionFemaleHumansHydrocephalus, Normal PressureImage Processing, Computer-AssistedIntracranial HypertensionLateral VentriclesMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsConceptsNormal pressure hydrocephalusPressure hydrocephalusIdiopathic normal pressure hydrocephalusManual volumetric analysisVoxel-based morphometric analysisCaudate nucleus volumeStructural volumetric changesINPH patientsReversible dementiaINPH groupHealthy controlsCaudate nucleusStructural abnormalitiesCognitive deficitsVolumetric analysisNucleus volumeHydrocephalusRegion of interestROI measurementsINPHMorphometric analysisAffective changes