2012
Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism
Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology 2012, 222: 129-140. PMID: 22311382, PMCID: PMC3674025, DOI: 10.1007/s00213-011-2628-2.Peer-Reviewed Original ResearchConceptsNMDA receptor antagonistFamily historyFHN subjectsReceptor antagonistFHP subjectsN-methyl-D-aspartate receptor functionReceptor functionIdentical-appearing placeboEffects of memantineFMRI activityNMDA receptor functionCorrect rejectsSingle doseMemantineGo/No-Go taskSeparate daysTemporal regionsCingulate activation
2007
Caudate structural abnormalities in idiopathic normal pressure hydrocephalus
DeVito E, Salmond C, Owler B, Sahakian B, Pickard J. Caudate structural abnormalities in idiopathic normal pressure hydrocephalus. Acta Neurologica Scandinavica 2007, 116: 328-332. PMID: 17922726, DOI: 10.1111/j.1600-0404.2007.00906.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrophyBasal Ganglia DiseasesCaudate NucleusCerebrospinal Fluid PressureCorpus CallosumDisease ProgressionFemaleHumansHydrocephalus, Normal PressureImage Processing, Computer-AssistedIntracranial HypertensionLateral VentriclesMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsConceptsNormal pressure hydrocephalusPressure hydrocephalusIdiopathic normal pressure hydrocephalusManual volumetric analysisVoxel-based morphometric analysisCaudate nucleus volumeStructural volumetric changesINPH patientsReversible dementiaINPH groupHealthy controlsCaudate nucleusStructural abnormalitiesCognitive deficitsVolumetric analysisNucleus volumeHydrocephalusRegion of interestROI measurementsINPHMorphometric analysisAffective changes