2011
Reliance on habits at the expense of goal-directed control following dopamine precursor depletion
de Wit S, Standing HR, DeVito EE, Robinson OJ, Ridderinkhof KR, Robbins TW, Sahakian BJ. Reliance on habits at the expense of goal-directed control following dopamine precursor depletion. Psychopharmacology 2011, 219: 621-631. PMID: 22134475, PMCID: PMC3249188, DOI: 10.1007/s00213-011-2563-2.Peer-Reviewed Original ResearchConceptsDopamine functionOutcome devaluation testRecent animal studiesGoal-directed action controlRole of dopamineStimulus-response habitsPlacebo groupDietary interventionHabitual controlTyrosine depletionHealthy volunteersDietary phenylalanineAnimal studiesFemale volunteersStimulus-response learningAction controlGoal-directed actionsDopamineSubject comparisonsVolunteersOutcomesGender differencesRewarding outcomesInitial learning phaseGoal-directed control
2010
Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ. Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males. Psychopharmacology 2010, 211: 187-195. PMID: 20495788, PMCID: PMC2892070, DOI: 10.1007/s00213-010-1880-1.Peer-Reviewed Original ResearchConceptsDA synthesisHealthy individualsParkinson's diseaseMale subjectsPlacebo-controlled crossover designCertain psychiatric disordersPunishment processingDA depletionDopamine synthesisHealthy femalesPsychiatric disordersCrossover designFemale subjectsDiseaseNeurotransmitter dopamineGender biasesReward processingThree-way interactionReversal learningSubjectsDepletion procedurePunishment predictionGender differencesSignificant improvement