2022
Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects
DeVito E, Sofuoglu M. Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects. Current Behavioral Neuroscience Reports 2022, 9: 113-123. PMID: 36644316, PMCID: PMC9838826, DOI: 10.1007/s40473-022-00251-2.Peer-Reviewed Original ResearchSmoking behaviorPreliminary dataHuman laboratory studiesCigarette smoking behaviorShort-term abstinenceNicotine administrationSmoking cessationTreatment optionsWithdrawal symptomsCessation outcomesPharmacogenetic effectsOvernight abstinenceMet carriersSmoking urgesActivity genotypeReviewThis articleSymptomsCOMT geneSex differencesAbstinenceFunctional variantsSmokingCigarettesAdministrationIndividuals
2021
Electronic Nicotine Delivery Systems (ENDS) Use and Pregnancy II: Perinatal Outcomes Following ENDS Use During Pregnancy
DeVito EE, Fagle T, Allen AM, Pang RD, Petersen N, Smith PH, Weinberger AH. Electronic Nicotine Delivery Systems (ENDS) Use and Pregnancy II: Perinatal Outcomes Following ENDS Use During Pregnancy. Current Addiction Reports 2021, 8: 366-379. PMID: 35368552, PMCID: PMC8974704, DOI: 10.1007/s40429-021-00381-9.Peer-Reviewed Original ResearchAdverse perinatal outcomesElectronic nicotine delivery systems (ENDS) usePerinatal outcomesHarm reduction approachENDS useCC smokingClinical recommendationsPregnancy IIPregnancyReviewThis reviewTobacco regulatory scienceLimited sample sizeOutcomesInsufficient dataRiskCurrent dataENDSWarrants concernSufficient dataSample sizeSmokingFindingsSystem useElectronic Nicotine Delivery Systems (ENDS) Use and Pregnancy I: ENDS Use Behavior During Pregnancy
DeVito EE, Fagle T, Allen AM, Pang RD, Petersen N, Smith PH, Weinberger AH. Electronic Nicotine Delivery Systems (ENDS) Use and Pregnancy I: ENDS Use Behavior During Pregnancy. Current Addiction Reports 2021, 8: 347-365. PMID: 34513567, PMCID: PMC8425312, DOI: 10.1007/s40429-021-00380-w.Peer-Reviewed Original ResearchElectronic nicotine delivery systemsTobacco product useENDS useCC smokingPregnant personsElectronic nicotine delivery systems (ENDS) useExclusive ENDS useProduct useNicotine delivery systemsLow-risk alternativeTobacco product landscapePregnancy IPregnancyInsufficient evidenceReviewThis reviewSmokingPrevalenceDelivery systemUse behaviorsDual usePersonsCessation
2018
E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders
DeVito E, Buta E, Sofuoglu M. E-cigarette nicotine dose and flavor: Relationship with appeal, choice, and tobacco use amongst veterans with comorbid psychiatric disorders. Addictive Behaviors 2018, 92: 53-57. PMID: 30583091, PMCID: PMC6699503, DOI: 10.1016/j.addbeh.2018.12.013.Peer-Reviewed Original ResearchConceptsElectronic cigarettesNicotine levelsTobacco useTake-home trialOne monthNicotine electronic cigarettesHigh nicotine dependenceComorbid psychiatric disordersSmoking-related outcomesCombustible cigarette useNicotine e-liquidCombustible tobacco useBaseline characteristicsCessation aidCigarette smokersSmoking characteristicsNicotine doseWorse outcomesEC efficacyNicotine dependenceSmokersPsychiatric disordersCigarette useCombustible cigarettesSmoking
2015
A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans
Jensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. Neuropsychopharmacology 2015, 40: 2813-2821. PMID: 25948103, PMCID: PMC4864657, DOI: 10.1038/npp.2015.131.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCognition DisordersCotinineFemaleGenome-Wide Association StudyHeart RateHumansMaleMiddle AgedNerve Tissue ProteinsNeuropsychological TestsNicotineNicotinic AgonistsPolymorphism, Single NucleotideReceptors, NicotinicSmokingSubstance Withdrawal SyndromeSurveys and QuestionnairesConceptsAversive effectsHeavy smokingRisk allelesSmoking-related disordersAfrican American smokersCHRNA5-CHRNA3Doses of nicotineHigh nicotine doseNicotine administrationIntravenous doseNicotine effectsNicotine doseAmerican smokersWithdrawal severityOvernight abstinenceAcute responseAA subjectsCardiovascular reactivityCHRNB4 gene clusterNicotineEuropean AmericansAversive responsesAdministration sessionsSmokingCognitive performance