2018
Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
Carroll KM, Nich C, DeVito EE, Shi JM, Sofuoglu M. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal Of Clinical Psychiatry 2018, 79: 17m11669. PMID: 29286595, PMCID: PMC5866530, DOI: 10.4088/jcp.17m11669.Peer-Reviewed Original ResearchConceptsComputerized cognitive behavioral therapyStandard methadone treatmentCocaine use outcomesBenefits of galantamineMethadone treatmentCognitive behavioral therapyCognitive functionUse outcomesCommunity-based methadone maintenance programCocaine useStandard methadone maintenance treatmentBehavioral therapyUrine toxicology screenMethadone maintenance treatmentMethadone maintenance programCocaine treatment outcomesNicotinic acetylcholine receptorsCognitive functioningCocaine use disorderMethadone dosingSecondary outcomesToxicology screenMaintenance treatmentClinical trialsMedication administration
2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2015
Catehol‐o‐methyltransferase gene Val158met polymorphism as a potential predictor of response to computer‐assisted delivery of cognitive‐behavioral therapy among cocaine‐dependent individuals: Preliminary findings from a randomized controlled trial
Carroll KM, Herman A, DeVito EE, Frankforter TL, Potenza MN, Sofuoglu M. Catehol‐o‐methyltransferase gene Val158met polymorphism as a potential predictor of response to computer‐assisted delivery of cognitive‐behavioral therapy among cocaine‐dependent individuals: Preliminary findings from a randomized controlled trial. American Journal On Addictions 2015, 24: 443-451. PMID: 25930952, PMCID: PMC4516567, DOI: 10.1111/ajad.12238.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyVal carriersStandard treatmentCocaine-dependent individualsCocaine useStandard methadone maintenance treatmentComputer-assisted deliveryMethadone maintenance treatmentMet/Met genotypeRate of participantsSignificant treatment conditionLess cocaine useCOMT Val108/158Met polymorphismPreliminary data pointUncontrolled studiesMaintenance treatmentContinuous abstinenceTreatment outcomesTreatment responseWeek trialMet genotypePotential biomarkersBehavioral therapyVal108/158Met polymorphism