2024
Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study
Zheng J, Steur M, Imamura F, Freisling H, Johnson L, van der Schouw Y, Tong T, Weiderpass E, Bajracharya R, Crous-Bou M, Dahm C, Heath A, Ibsen D, Jannasch F, Katzke V, Masala G, Moreno-Iribas C, Sacerdote C, Schulze M, Sieri S, Wareham N, Danesh J, Butterworth A, Forouhi N. Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study. American Journal Of Clinical Nutrition 2024, 119: 1164-1174. PMID: 38479550, PMCID: PMC11130694, DOI: 10.1016/j.ajcnut.2024.03.006.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseDietary protein intakeProtein intakeCase-cohort studyCardiovascular diseaseIncident cardiovascular diseaseFatal strokeAssociated with lower incidenceIncidence of fatal strokeRisk of cardiovascular diseaseEuropean Prospective InvestigationPrentice-weighted Cox regressionAssociated with incident cardiovascular diseaseOverall CVDIncident CVD casesIntake of plantMacronutrient intakeStroke incidenceProtein consumptionSubcohort membersIsocaloric substitutionDietary patternsDietary intakeNever smokersProspective Investigation
2023
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
Collaboration E, Sofianopoulou E, Kaptoge S, Afzal S, Jiang T, Gill D, Gundersen T, Bolton T, Allara E, Arnold M, Mason A, Chung R, Pennells L, Shi F, Sun L, Willeit P, Forouhi N, Langenberg C, Sharp S, Panico S, Engström G, Melander O, Tong T, Perez-Cornago A, Norberg M, Johansson I, Katzke V, Srour B, Sánchez M, Redondo-Sánchez D, Olsen A, Dahm C, Overvad K, Brustad M, Skeie G, Moreno-Iribas C, Onland-Moret N, van der Schouw Y, Tsilidis K, Heath A, Agnoli C, Krogh V, de Boer I, Kobylecki C, Çolak Y, Zittermann A, Sundström J, Welsh P, Weiderpass E, Aglago E, Ferrari P, Clarke R, Boutron M, Severi G, MacDonald C, Providencia R, Masala G, Zamora-Ros R, Boer J, Verschuren M, Cawthon P, Schierbeck L, Cooper C, Schulze M, Bergmann M, Hannemann A, Kiechl S, Brenner H, van Schoor N, Albertorio J, Sacerdote C, Linneberg A, Kårhus L, Huerta J, Imaz L, Joergensen C, Ben-Shlomo Y, Lundqvist A, Gallacher J, Sattar N, Wood A, Wareham N, Nordestgaard B, Di Angelantonio E, Danesh J, Butterworth A, Burgess S. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses. The Lancet Diabetes & Endocrinology 2023, 12: e2-e11. PMID: 38048800, PMCID: PMC7615586, DOI: 10.1016/s2213-8587(23)00287-5.Peer-Reviewed Original ResearchConceptsMendelian randomisation analysisCoronary heart diseaseRandomisation analysesAll-cause mortalityMortality outcomesFatal ischaemic heart diseaseHeart diseaseIncident coronary heart diseaseHistory of coronary heart diseasePopulation-based cohort studyHealth Data Research UKCause-specific mortality outcomesNational Institute for Health ResearchMendelian randomisation frameworkDose-response relationshipIndividuals of European ancestryRisk of coronary heart diseaseRandomised trials of vitamin D supplementationLow vitamin D statusBritish Heart FoundationCancer Research UKInternational Agency for Research on CancerMiddle-aged individualsIschaemic heart diseaseMedical Research CouncilDietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries
Tong T, Clarke R, Schmidt J, Huybrechts I, Noor U, Forouhi N, Imamura F, Travis R, Weiderpass E, Aleksandrova K, Dahm C, van der Schouw Y, Overvad K, Kyrø C, Tjønneland A, Kaaks R, Katzke V, Schiborn C, Schulze M, Mayen-Chacon A, Masala G, Sieri S, de Magistris M, Tumino R, Sacerdote C, Boer J, Verschuren W, Brustad M, Nøst T, Crous-Bou M, Petrova D, Amiano P, Huerta J, Moreno-Iribas C, Engström G, Melander O, Johansson K, Lindvall K, Aglago E, Heath A, Butterworth A, Danesh J, Key T. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries. European Journal Of Nutrition 2023, 63: 209-220. PMID: 37804448, PMCID: PMC10799144, DOI: 10.1007/s00394-023-03251-4.Peer-Reviewed Original ResearchConceptsRisk of ischaemic strokeHaemorrhagic strokeRisk of stroke subtypesMultivariable-adjusted Cox regression modelsHazard ratioIschaemic strokeStroke subtypesCountry-specific dietary questionnairesBlood pressureConfidence intervalsEstimate hazard ratiosProline intakeMethodsWe analysed dataMultiple testingStatistically significant associationDietary recallsDietary questionnaireInverse associationCox regression modelsDiastolic blood pressureEPIC studyHigher intakeDietary amino acidsDietary intakeMutual adjustmentAge at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women
Tschiderer L, Peters S, van der Schouw Y, van Westing A, Tong T, Willeit P, Seekircher L, Moreno‐Iribas C, Huerta J, Crous‐Bou M, Söderholm M, Schulze M, Johansson C, Själander S, Heath A, Macciotta A, Dahm C, Ibsen D, Pala V, Mellemkjær L, Burgess S, Wood A, Kaaks R, Katzke V, Amiano P, Rodriguez‐Barranco M, Engström G, Weiderpass E, Tjønneland A, Halkjær J, Panico S, Danesh J, Butterworth A, Onland‐Moret N. Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women. Journal Of The American Heart Association 2023, 12: e030280. PMID: 37681566, PMCID: PMC10547274, DOI: 10.1161/jaha.123.030280.Peer-Reviewed Original ResearchConceptsMendelian randomization analysisRisk of strokeStatistically significant associationRandomization analysisSignificant associationHistory of strokeEPIC-CVDPooled mean ageHigh risk of strokeUK BiobankYears younger ageBaseline ageHazard ratioStroke subtypesObservational studyPooled hazard ratioHemorrhagic strokeEarly menopauseYounger ageMean ageHigh riskMedian follow-upStrokeRegression analysisWomen