Prediagnostic Hormone Levels and Risk of Testicular Germ Cell Tumors: A Nested Case-Control Study in the Janus Serum Bank.
Wu Z, Trabert B, Guillemette C, Caron P, Bradwin G, Graubard B, Weiderpass E, Ursin G, Langseth H, McGlynn K. Prediagnostic Hormone Levels and Risk of Testicular Germ Cell Tumors: A Nested Case-Control Study in the Janus Serum Bank. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1564-1571. PMID: 37619591, PMCID: PMC10655159, DOI: 10.1158/1055-9965.epi-23-0772.Peer-Reviewed Original ResearchConceptsTesticular germ cell tumorsDevelopment of testicular germ cell tumorsRisk of testicular germ cell tumorsGerm cell tumorsNested case-control studyFollicle-stimulating hormoneCase-control studyFSH levelsHigher FSH levelsSertoli cellsCell tumorsLuteinizing hormoneHormone levelsLevels of serum gonadotropinsTesticular germ cell tumour riskJanus Serum Bank CohortAssociated with TGCT riskSex hormone binding globulinIncreased FSH levelsConfidence intervalsMultivariate logistic regressionLevels of androgensSex steroid hormonesLH levelsBinding globulin