2024
Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
Matta K, Viallon V, Botteri E, Peveri G, Dahm C, Nannsen A, Olsen A, Tjønneland A, Elbaz A, Artaud F, Marques C, Kaaks R, Katzke V, Schulze M, Llanaj E, Masala G, Pala V, Panico S, Tumino R, Ricceri F, Derksen J, Nøst T, Sandanger T, Borch K, Quirós J, Castro-Espin C, Sánchez M, Atxega A, Cirera L, Guevara M, Manjer J, Tin Tin S, Heath A, Touvier M, Goldberg M, Weiderpass E, Gunter M, Freisling H, Riboli E, Ferrari P. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort. BMC Medicine 2024, 22: 210. PMID: 38807179, PMCID: PMC11134634, DOI: 10.1186/s12916-024-03362-7.Peer-Reviewed Original ResearchConceptsHealthy lifestyle indexAssociated with all-causeHealthy lifestyle changesEuropean Prospective InvestigationRisk of deathCancer mortalityFollow-up questionnaireAll-causeLifestyle changesProspective InvestigationRate advancement periodsUnhealthy lifestyle changesRisk of noncommunicable diseasesCancer and NutritionCancer-free adultsBody mass indexBackgroundHealthy lifestylesLifestyle behaviorsNutrition CohortLifestyle indexLifestyle ProfilePhysical activityAssociated with mortalityNoncommunicable diseasesChange scoresDietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study
Zheng J, Steur M, Imamura F, Freisling H, Johnson L, van der Schouw Y, Tong T, Weiderpass E, Bajracharya R, Crous-Bou M, Dahm C, Heath A, Ibsen D, Jannasch F, Katzke V, Masala G, Moreno-Iribas C, Sacerdote C, Schulze M, Sieri S, Wareham N, Danesh J, Butterworth A, Forouhi N. Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case–cohort study. American Journal Of Clinical Nutrition 2024, 119: 1164-1174. PMID: 38479550, PMCID: PMC11130694, DOI: 10.1016/j.ajcnut.2024.03.006.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseDietary protein intakeProtein intakeCase-cohort studyCardiovascular diseaseIncident cardiovascular diseaseFatal strokeAssociated with lower incidenceIncidence of fatal strokeRisk of cardiovascular diseaseEuropean Prospective InvestigationPrentice-weighted Cox regressionAssociated with incident cardiovascular diseaseOverall CVDIncident CVD casesIntake of plantMacronutrient intakeStroke incidenceProtein consumptionSubcohort membersIsocaloric substitutionDietary patternsDietary intakeNever smokersProspective InvestigationInflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
Mandle H, Jenab M, Gunter M, Tjønneland A, Olsen A, Dahm C, Zhang J, Sugier P, Rothwell J, Severi G, Kaaks R, Katzke V, Schulze M, Masala G, Sieri S, Panico S, Sacerdote C, Bonet C, Sánchez M, Amiano P, Huerta J, Guevara M, Palmqvist R, Löwenmark T, Perez-Cornago A, Weiderpass E, Heath A, Cross A, Vineis P, Hughes D, Fedirko V. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations. Mutagenesis 2024, geae008. PMID: 38441165, DOI: 10.1093/mutage/geae008.Peer-Reviewed Original ResearchRectal cancer riskColorectal cancer riskCancer riskSingle-nucleotide polymorphismsAssociated with rectal cancer riskColorectal cancerAssociated with rectal cancerIncident CRC casesAssociated with colon cancerEuropean Prospective InvestigationSingle-nucleotide polymorphism levelColon cancerGut barrier functionUnique single-nucleotide polymorphismsNutrition CohortEuropean populationsCRC casesCrohn's diseaseUnadjusted p-valuesProspective InvestigationInvestigate associationsGene levelColorectal cancer developmentBarrier functionGut barrier permeabilityCirculating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
Rinaldi S, Dossus L, Keski‐Rahkonen P, Kiss A, Navionis A, Biessy C, Travis R, Weiderpass E, Romieu I, Eriksen A, Tjonneland A, Kvaskoff M, Canonico M, Truong T, Katzke V, Kaaks R, Catalano A, Panico S, Masala G, Tumino R, Lukic M, Olsen K, Zamora‐Ros R, Santiuste C, Atxega A, Guevara M, Rodriguez‐Barranco M, Sandstrom M, Hennings J, Almquist M, Kouassivi E, Christakoudi S, Gunter M, Franceschi S. Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women. International Journal Of Cancer 2024, 154: 2064-2074. PMID: 38357914, DOI: 10.1002/ijc.34872.Peer-Reviewed Original ResearchConceptsSex hormone binding globulinSex steroid hormonesThyroid cancerRisk of differentiated thyroid carcinomaOdds ratioSex steroidsSex hormone binding globulin concentrationsSteroid hormonesCancer-free controlsPre-menopausal womenRisk of differentiated TCEuropean Prospective InvestigationPost-menopausal womenEndogenous sex steroidsBorderline significant increaseConditional logistic regression modelsSex steroid productionNo significant associationCirculating sex steroidsCirculating sex steroid hormonesPostmenopausal womenConcentrations of testosteroneProgesterone/estradiol ratioThyroid carcinomaBorderline decreasePre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study
Pham T, Nimptsch K, Aleksandrova K, Jenab M, Fedirko V, Wu K, Eriksen A, Tjønneland A, Severi G, Rothwell J, Kaaks R, Katzke V, Catalano A, Agnoli C, Masala G, De Magistris M, Tumino R, Vermeulen R, Aizpurua A, Trobajo‐Sanmartín C, Chirlaque M, Sánchez M, San Moon Lu S, Cross A, Christakoudi S, Weiderpass E, Pischon T. Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study. International Journal Of Cancer 2024, 154: 1596-1606. PMID: 38200695, DOI: 10.1002/ijc.34830.Peer-Reviewed Original ResearchColorectal cancer diagnosisCRC-specific mortalityEuropean Prospective InvestigationAll-cause mortalityCox proportional hazards modelsProportional hazards modelColorectal cancerCRC-specificAssociated with CRC-specific mortalityPre-diagnosticResistin concentrationsProspective InvestigationHazards modelHazard ratioIncident CRC casesFine-Gray proportional subdistribution hazards modelCause-specific Cox proportional hazards modelsSubgroup analysisBody mass indexNutrition CohortProportional subdistribution hazards modelMedian follow-upAssociated with increased mortalitySubdistribution hazard modelCRC casesLifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition
Botteri E, Peveri G, Berstad P, Bagnardi V, Hoff G, Heath A, Cross A, Vineis P, Dossus L, Johansson M, Freisling H, Matta K, Huybrechts I, Chen S, B. Borch K, Sandanger T, H. Nøst T, Dahm C, Antoniussen C, Tin Tin S, Fournier A, Marques C, Artaud F, Sánchez M, Guevara M, Santiuste C, Agudo A, Bajracharya R, Katzke V, Ricceri F, Agnoli C, Bergmann M, Schulze M, Panico S, Masala G, Tjønneland A, Olsen A, Stocks T, Manjer J, Aizpurua-Atxega A, Weiderpass E, Riboli E, Gunter M, Ferrari P. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition. European Journal Of Epidemiology 2024, 39: 147-159. PMID: 38180593, DOI: 10.1007/s10654-023-01059-4.Peer-Reviewed Original ResearchHealthy lifestyle indexLifestyle-related cancersFollow-up questionnaireCancer riskHealthy lifestyle index scoreLifestyle changesHazard ratioConfidence intervalsEuropean Prospective InvestigationFollow-upMiddle-aged participantsBody mass indexLifestyle indexPhysical activityBottom thirdLifestyle questionnaireLifestyle habitsEPIC cohortProspective InvestigationAlcohol consumptionCox regression modelsMass indexCigarette smokingLifestyleQuestionnaire
2023
Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis
Morales-Berstein F, Biessy C, Viallon V, Goncalves-Soares A, Casagrande C, Hémon B, Kliemann N, Cairat M, Blanco Lopez J, Al Nahas A, Chang K, Vamos E, Rauber F, Bertazzi Levy R, Barbosa Cunha D, Jakszyn P, Ferrari P, Vineis P, Masala G, Catalano A, Sonestedt E, Borné Y, Katzke V, Bajracharya R, Agnoli C, Guevara M, Heath A, Radoï L, Mancini F, Weiderpass E, Huerta J, Sánchez M, Tjønneland A, Kyrø C, Schulze M, Skeie G, Lukic M, Braaten T, Gunter M, Millett C, Agudo A, Brennan P, Borges M, Richmond R, Richardson T, Davey Smith G, Relton C, Huybrechts I. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal Of Nutrition 2023, 63: 377-396. PMID: 37989797, PMCID: PMC10899298, DOI: 10.1007/s00394-023-03270-1.Peer-Reviewed Original ResearchConceptsConsumption of ultra-processed foodsUltra-processed foodsWaist-to-hip ratioRisk of head and neck cancerUltra-processed food consumptionOesophageal adenocarcinoma riskEuropean Prospective InvestigationBody mass indexHead and neck cancerIncreased risk of HNCHigher consumption of ultra-processed foodsHead and neck cancer riskProspective InvestigationCancer and NutritionNegative control analysesOesophageal adenocarcinomaWaist-to-hipNegative control outcomesAssociated with greater riskMediation analysisNeck cancerAccidental deathEPIC participantsMass indexGreater riskDietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries
Fiolet T, Nicolas G, Casagrande C, Horvath Z, Frenoy P, Weiderpass E, Gunter M, Manjer J, Sonestedt E, Palli D, Simeon V, Tumino R, Bueno-de-Mesquita B, Huerta J, Rodriguez-Barranco M, Abilleira E, Sacerdote C, Schulze M, Heath A, Rylander C, Skeie G, Nøst T, Tjønneland A, Olsen A, Pala V, Kvaskoff M, Huybrechts I, Mancini F. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries. International Journal Of Hygiene And Environmental Health 2023, 255: 114287. PMID: 37989047, DOI: 10.1016/j.ijheh.2023.114287.Peer-Reviewed Original ResearchConceptsDietary intakeCause mortalityCohort studyIntake of dioxinsCancer mortalityGeneral populationEPIC cohort studyMultivariable Cox regressionEuropean Prospective InvestigationCardiovascular-specific mortalityMain exposure sourceNDL-PCBsFood consumption dataFood contamination dataSerum/plasmaNon-linear associationNutrition CohortCardiovascular mortalityHazard ratioCox regressionNon-monotonic dose responsesProspective InvestigationEuropean Food Safety AuthorityMortalityInconsistent associationsPrediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study
Hughes D, Schomburg L, Jenab M, Biessy C, Méplan C, Moskal A, Sun Q, Demircan K, Fedirko V, Weiderpass E, Mukhtar M, Olsen A, Tjønneland A, Overvad K, Schulze M, Nøst T, Skeie G, Olsen K, Ricceri F, Grioni S, Palli D, Masala G, Tumino R, Pasanisi F, Amiano P, Colorado Yohar S, Agudo A, Sánchez M, Ardanaz E, Sund M, Andersson A, Perez-Cornago A, Travis R, Heath A, Dossus L. Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study. Free Radical Biology And Medicine 2023, 209: 381-393. PMID: 37923090, DOI: 10.1016/j.freeradbiomed.2023.10.401.Peer-Reviewed Original ResearchConceptsAssociated with BC riskBC riskCase-control pairsOdds ratioMultivariable-adjusted logistic regression modelsBreast cancer riskInfluence BC riskCancer and NutritionConfidence intervalsEuropean Prospective InvestigationHigher risk of BCPremenopausal BC riskRisk of BCPrevent breast cancerAssociated with lower riskEuropean cohort studiesBreast cancerGenetic variant associationsLogistic regression modelsGlutathione peroxidase 3Multiple testing correctionStatistically significant associationPremenopausal BCCancer riskVariant associationsProspective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Nimptsch K, Aleksandrova K, Pham T, Papadimitriou N, Janke J, Christakoudi S, Heath A, Olsen A, Tjønneland A, Schulze M, Katzke V, Kaaks R, van Guelpen B, Harbs J, Palli D, Macciotta A, Pasanisi F, Yohar S, Guevara M, Amiano P, Grioni S, Jakszyn P, Figueiredo J, Samadder N, Li C, Moreno V, Potter J, Schoen R, Um C, Weiderpass E, Jenab M, Gunter M, Pischon T. Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer. BMC Medicine 2023, 21: 391. PMID: 37833736, PMCID: PMC10576353, DOI: 10.1186/s12916-023-03104-1.Peer-Reviewed Original ResearchConceptsColorectal cancer riskColorectal cancer casesMendelian randomizationColorectal cancerEpidemiology of Colorectal Cancer ConsortiumAssociated with colorectal cancer riskTwo-sample Mendelian randomization studyColon Cancer Family RegistryPublished genome-wide association studiesColorectal Cancer ConsortiumCancer Family RegistryConditional logistic regression modelsMendelian randomization analysisMendelian randomization studiesCancer and NutritionEuropean Prospective InvestigationNested case-control studyGenome-wide association studiesLogistic regression modelsCase-control studyDevelopment of colorectal cancerFamily RegistryStatistically significant associationCancer ConsortiumCancer risk