2024
Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study
Afrane A, Alhassan Y, Amoah L, Nyarko M, Addo-Lartey A, Paintsil E, Torpey K. Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study. BMC Infectious Diseases 2024, 24: 1144. PMID: 39394078, PMCID: PMC11470549, DOI: 10.1186/s12879-024-09974-x.Peer-Reviewed Original ResearchConceptsVirological non-suppressionAsymptomatic malaria parasitaemiaKorle Bu Teaching HospitalLow transmission areasMalaria parasitaemiaAntiretroviral therapyNon-suppressionCross-sectional studyUndetectable viral load levelsProportion of HIV-infected childrenStudy populationBackgroundHuman immunodeficiency virusHIV-infected childrenPaediatric HIV clinicMalaria preventive behaviorsResultsThe median ageViral load levelsLow-level viraemiaTransmission areasMethodsThis cross-sectional studyAsymptomatic malariaMalaria parasitemiaMalaria casesChi-square testProportion of childrenPrevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana
Gyane F, Modey E, Maya E, Bonney E, Abaidoo-Myles A, Paintsil E, Torpey K. Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana. PLOS ONE 2024, 19: e0303535. PMID: 38814956, PMCID: PMC11139324, DOI: 10.1371/journal.pone.0303535.Peer-Reviewed Original ResearchConceptsTertiary health facilityHealth facilitiesInterviewer-administered questionnaireAnalytical cross-sectional studyCervical cancer screeningCervical cancerPrevention of cervical cancerCross-sectional studyRisk factor assessmentHR-HPVAttending HIV clinicsCancer screeningHIV diagnosisLogistic regression analysisDemographic data collectionHigh-risk human papillomavirus infectionPrevalence of HR-HPVHIV clinicHigher oddsWLWHDescriptive statisticsStudy participantsHigh-risk patient groupsMultiple HPV genotypesPrevalence of HPVScreening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence
Adu-Gyamfi R, Enos J, Yeboah K, Shabanova V, Hawley N, Ogum D, Nkansah A, Paintsil E, Torpey K. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. PLOS ONE 2024, 19: e0302016. PMID: 38701070, PMCID: PMC11068165, DOI: 10.1371/journal.pone.0302016.Peer-Reviewed Original ResearchConceptsTheory-based interventionsImplementation of clinical practice guidelinesClinic visitsProvision of job aidsHealthcare workers' adherenceCluster randomized trialAvailability of guidelinesClinical practice guidelinesBehavior-based interventionsCluster-randomized studyAntiretroviral therapy sitesCardiovascular disease-related morbidityBlood pressureAIDS-related deathsIntervention facilitiesGreater Accra Region of GhanaAccra Region of GhanaGuideline adherenceHypertension screeningAntiretroviral careWorker adherenceIncidence of hypertensionHypertension riskGreater Accra RegionJob aidsClinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV
Amegashie E, Asamoah P, Ativi L, Adusei-Poku M, Bonney E, Tagoe E, Paintsil E, Torpey K, Quaye O. Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV. Experimental Biology And Medicine 2024, 249: 10059. PMID: 38628843, PMCID: PMC11020089, DOI: 10.3389/ebm.2024.10059.Peer-Reviewed Original ResearchConceptsLevels of inflammatory markersResponse to SARS-CoV-2 infectionClinical outcomesSARS-CoV-2 infectionCo-infectionInflammatory markersSARS-CoV-2HIV patients co-infectedImmune response to SARS-CoV-2 infectionCD4<sup>+</sup> countInitiation of ARTT cell exhaustionPatients co-infectedSevere outcomesAssociated with severe outcomesStudy assessed risk factorsMono-infected individualsResponse to SARS-CoV-2Respiratory tract infectionsImmunological response to SARS-CoV-2Immunological response to SARS-CoV-2 infectionAfrican American raceChronic kidney diseaseIntensive care unitPositive conversion rateEditorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce
Paintsil E. Editorial: Emerging and reemerging global pediatric infectious diseases amidst vanishing pediatric infectious diseases workforce. Current Opinion In Pediatrics 2024, 36: 133-135. PMID: 38446143, DOI: 10.1097/mop.0000000000001328.Peer-Reviewed Original ResearchConceptsPediatric infectious diseases
2023
Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience
Shabanova V, Emuren L, Gan G, Antwi S, Renner L, Amissah K, Kusah J, Lartey M, Reynolds N, Paintsil E. Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 371-380. PMID: 37643414, PMCID: PMC10617661, DOI: 10.1097/qai.0000000000003292.Peer-Reviewed Original ResearchConceptsHIV disclosure interventionsVirologic outcomesCD4 percentWeek 48HIV statusIntervention groupHIV disclosureDisclosure interventionDetectable viral loadWorld Health OrganizationAntiretroviral therapyImmunologic outcomesClinical outcomesIntervention armViral loadControl armClinical trialsTrial experienceSecondary analysisDisclosure statusHealth OrganizationCategorical variablesWeeksLinear mixed modelsBaselineSupporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States
Mohammed A, Idris-Dantata H, Okwor T, Tanui P, Paintsil E, Kabwe P, Alimi Y, Tajudeen R, Mankoula W, Ilesanmi O, Balogun M, Ihekweazu C, Hornsey E, Ogbuagu O. Supporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States. Global Health Science And Practice 2023, 11: e2300121. PMID: 37903581, PMCID: PMC10615240, DOI: 10.9745/ghsp-d-23-00121.Peer-Reviewed Original ResearchA continent-wide effort and solidarity at curbing COVID-19 pandemic: the Africa task force for novel coronavirus (AFTCOR) infection prevention and control technical working group’s experience
Paintsil E, Alimi Y, Abdulaziz M, Ogbuagu O, Ogunsola F, Kessy S, Horsney E, Lee C, Brundney K, Okwor T, Kabwe P, Waheed A, Vondran A, Bigirimana R, Ilesanmi O, Nsubuga D, Raji T, Mankoula W, Ihekweazu C, Nkengasong J. A continent-wide effort and solidarity at curbing COVID-19 pandemic: the Africa task force for novel coronavirus (AFTCOR) infection prevention and control technical working group’s experience. BMC Public Health 2023, 23: 893. PMID: 37189137, PMCID: PMC10184057, DOI: 10.1186/s12889-023-15706-8.Peer-Reviewed Original ResearchConceptsInfection preventionCDC websiteNovel coronavirus disease (COVID-19) outbreakService delivery pointsCoronavirus disease (COVID-19) outbreakTask ForceIPC trainingResearch subgroupsIPC programIPC measuresHealth personnelDisease controlWorking GroupImplementation researchOutbreaks of diseaseSubgroupsPreventionCOVID-19COVID-19 pandemicTechnical Working GroupAfrica CentrePerson trainingTraining subgroupFocal personsDisease outbreaks
2022
Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data
Fashina T, Miller C, Paintsil E, Niccolai L, Brandt C, Oliveira C. Computable Clinical Phenotyping of Postacute Sequelae of COVID-19 in Pediatrics Using Real-World Data. Journal Of The Pediatric Infectious Diseases Society 2022, 12: 113-116. PMID: 36548966, PMCID: PMC9969330, DOI: 10.1093/jpids/piac132.Peer-Reviewed Original ResearchCommunity engagement in Ebola outbreaks in sub-Saharan Africa and implications for COVID-19 control: A scoping review
Frimpong S, Paintsil E. Community engagement in Ebola outbreaks in sub-Saharan Africa and implications for COVID-19 control: A scoping review. International Journal Of Infectious Diseases 2022, 126: 182-192. PMID: 36462575, DOI: 10.1016/j.ijid.2022.11.032.Peer-Reviewed Original ResearchConceptsEbola virus disease outbreakSaharan AfricaCommunity-based interventionsVirus disease outbreakCOVID-19 preventionCase seriesTreatment uptakeEmbase databasesCase detectionObservational studyCOVID-19 controlCOVID-19 pandemic preventionCase findingSurvival rateEVD outbreakFinal reviewStudy typeQuasiexperimental studyPreventionReview criteriaEbola outbreakPandemic preventionDisease outbreaksOutbreakTotal
2014
Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition
Selvaraj S, Ghebremichael M, Li M, Foli Y, Langs-Barlow A, Ogbuagu A, Barakat L, Tubridy E, Edifor R, Lam W, Cheng Y, Paintsil E. Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition. Clinical Pharmacology & Therapeutics 2014, 96: 110-120. PMID: 24637942, PMCID: PMC4065195, DOI: 10.1038/clpt.2014.64.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsATP-Binding Cassette TransportersCase-Control StudiesDeoxyribonucleotidesDNA Polymerase gammaDNA, MitochondrialDNA-Directed DNA PolymeraseFemaleGene DosageHIV InfectionsHumansMaleMiddle AgedMitochondriaNucleic Acid Synthesis InhibitorsNucleotide Transport ProteinsNucleotidesReverse Transcriptase InhibitorsRibonucleotidesConceptsAntiretroviral therapyPeripheral blood mononuclear cellsMitochondrial toxicityBlood mononuclear cellsNegative controlMitochondrial DNA copy numberMononuclear cellsDNA copy numberMitochondrial dysfunctionHigh expression levelsPotential mechanismsGroup differencesExpression levelsPositive controlTherapyMedian valueToxicityDeoxyribonucleotide poolsCellular kinasesCassette proteinCellsDysfunctionTriphosphateControl