2024
Changes in Frontoamygdala Circuitry Associated With a Parent-Focused Intervention for Pediatric Anxiety Disorders
Gee D, Gunther K, Petrie D, Kitt E, Keding T, Broussard A, Zacharek S, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Odriozola P, Marin C, Silverman W, Lebowitz E. Changes in Frontoamygdala Circuitry Associated With a Parent-Focused Intervention for Pediatric Anxiety Disorders. Biological Psychiatry 2024, 95: s44. DOI: 10.1016/j.biopsych.2024.02.110.Peer-Reviewed Original ResearchFamily Accommodation in Anxious Irritable and Anxious Nonirritable Youth
Budagzad-Jacobson R, Musicaro R, Marin C, Silverman W, Lebowitz E. Family Accommodation in Anxious Irritable and Anxious Nonirritable Youth. Behavior Therapy 2024, 55: 913-921. PMID: 39174269, PMCID: PMC11341947, DOI: 10.1016/j.beth.2024.03.003.Peer-Reviewed Original ResearchFamily accommodationIrritable youthYouth anxietyParent ratingsCo-occurrence of anxietyLevels of irritabilityInfluence of irritabilityClinic-referredAnxiety disordersDiagnostic InterviewChild anxietyYouth ratingsAnxietyAccommodation behaviorAnxiety levelsTreatment targetModerating effectIrritability levelsYouthCo-occurrenceParentsIrritationDisordersFindingsAssociationResponding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2023
Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships?
Etkin R, Juel E, Lebowitz E, Silverman W. Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships? Clinical Child And Family Psychology Review 2023, 26: 1052-1076. PMID: 37838627, DOI: 10.1007/s10567-023-00454-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCognitive behavioral therapyAdolescent anxiety disordersPeer relationshipsSocial functioningAnxiety disordersYouth anxiety disordersPeer outcomesAnxiety reductionTreatment-specific effectsFunctioningTreatment specificitySystematic narrative reviewRelated difficultiesSample characteristicsMajority of studiesSpecific outcomesChildrenTreatment outcomesStatistical findingsStudy sampleDisordersNarrative reviewFindingsRelationshipAnxietyAffective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task
Nook E, Nardini C, Zacharek S, Hommel G, Spencer H, Martino A, Morra A, Flores S, Anderson T, Marin C, Silverman W, Lebowitz E, Gee D. Affective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task. Emotion 2023, 23: 1513-1521. PMID: 36595385, PMCID: PMC10314965, DOI: 10.1037/emo0001203.Peer-Reviewed Original ResearchConceptsNegative affect wordsChallenging puzzle taskAffect wordsAffective languagePuzzle taskEffective emotion regulationSpread of emotionsEmotion regulationNeuroscientific levelAnxious childrenEmotional influencesWord useBidirectional influenceAnxiety disordersBidirectional relationsMother's directionsMental healthEmotionsFuture researchWordsCurrent studyLanguageChildrenTaskMothersOxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders
Zilcha-Mano S, Orbach M, Malka M, Lebowitz E. Oxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders. Journal Of Clinical Child & Adolescent Psychology 2023, ahead-of-print: 1-9. PMID: 37166402, PMCID: PMC10638466, DOI: 10.1080/15374416.2023.2188557.Peer-Reviewed Original ResearchSalivary OT levelsLine of researchAnxiety treatmentPositive mother-child interactionsChild anxiety treatmentChild anxiety disordersChildhood anxiety treatmentMother-child interactionMother-child dyadsHigher baseline levelsChildhood anxietyCBT treatmentGreater treatment efficacyDyadic interactionsAnxiety disordersTarget of treatmentOutcome moderatorsDisorder ScalePeripheral oxytocinEmotional Disorders (SCARED) scaleOT levelsNovel treatment targetsCBTModeratorMixed resultsThe Role of Family-Level Factors in Childhood Anxiety During the COVID-19 Pandemic
Kitt E, Cohodes E, McCauley S, Hommel G, Nardini C, Zacharek S, Martino A, Anderson T, Spencer H, Odriozola P, Spurrier G, Broussard A, Marin C, Silverman W, Lebowitz E, Gee D. The Role of Family-Level Factors in Childhood Anxiety During the COVID-19 Pandemic. Journal Of Emotion And Psychopathology 2023, 1: 129-151. DOI: 10.55913/joep.v1i1.18.Peer-Reviewed Original ResearchCOVID-19-related fearCOVID-19-related stressFamily-level factorsAmygdala reactivityAnxiety disordersChildren's useEmotion regulation strategiesParent-child dynamicsExpressive suppressionAnxious youthFearful facesChildhood anxietyFMRI taskPediatric anxietyRegulation strategiesOwn functioningCOVID-19 pandemicFamily exposureMultimodal studyFearPervasive disruptionChildren's exposureFamily lifeParental assistanceAnxietyChapter 19 Working with parents in the treatment of child and adolescent anxiety
Etkin R, Lebowitz E, Silverman W. Chapter 19 Working with parents in the treatment of child and adolescent anxiety. 2023, 341-358. DOI: 10.1016/b978-0-323-99613-6.00003-x.ChaptersAnxiety treatmentAdolescent anxietyAnxiety disordersChild anxiety treatmentIndividual child treatmentsAdolescent anxiety disordersExtant evidence baseParent variablesTreatment literatureChild's treatmentParent involvementParents' roleTreatment of childrenTheoretical importanceConsiderable methodological variationsEtiology of childrenMethodological variationsAnxietyParentsChildrenInvolvement approachEvidence baseValid inferencesConcrete recommendationsRich literature
2022
De behandeling van angst bij kinderen en jongeren. Op basis van CGT (cognitieve gedragstherapie) en geweldloos verzet
Omer H, Lebowitz E. De behandeling van angst bij kinderen en jongeren. Op basis van CGT (cognitieve gedragstherapie) en geweldloos verzet. 2022 DOI: 10.36254/978-90-8850-997-1.Peer-Reviewed Original Research
2021
An Initial Study of Symptom Accommodation in Adults with Depression
Leonard R, Guastello A, Cooke D, Storch E, Lebowitz E, Riemann B. An Initial Study of Symptom Accommodation in Adults with Depression. International Journal Of Cognitive Therapy 2021, 14: 537-551. DOI: 10.1007/s41811-020-00097-0.Peer-Reviewed Original ResearchSymptom accommodationObsessive-compulsive disorderAnger outburstsDepression severitySelf-report measuresResidential treatment programGood internal consistencyAnxiety sensitivitySocial anxietyExploratory factor analysisAnxiety disordersAccommodation behaviorSix-item scaleFrequency subscaleGreater depression severitySymptom courseTreatment programInternal consistencyFactor analysisMood disordersSignificant predictorsAnxietyDepressionTotal scoreSubscales
2020
Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder
Zhang Y, Liu W, Lebowitz ER, Zhang F, Hu Y, Liu Z, Yang H, Wu J, Wang Y, Silverman WK, Yang Z, Cheng W. Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder. Neuropharmacology 2020, 180: 108301. PMID: 32910952, DOI: 10.1016/j.neuropharm.2020.108301.Peer-Reviewed Original ResearchConceptsThalamic volumeThalamic asymmetryAge group differencesAbnormal asymmetryAnxiety disordersBilateral thalamic volumeAnxiety symptomsBrain developmental abnormalitiesOlder age groupsSocial anxiety disorderChronic family stressMedication-free childrenFunctional lateralizationMental disordersAge groupsChronic stressBrain developmentTotal SCARED scoresDisordersFamilial stressChildrenAnxiety severityAdolescentsEmotional disordersDevelopmental abnormalitiesParent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment
Zilcha-Mano S, Shimshoni Y, Silverman WK, Lebowitz ER. Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 427-439. PMID: 32401557, PMCID: PMC8496486, DOI: 10.1080/15374416.2020.1756300.Peer-Reviewed Original ResearchConceptsParent-child agreementFamily accommodationMultilevel response-surface analysisAnxious Childhood EmotionsChild anxiety treatmentChild anxiety severityCognitive behavioral therapyAnxiety symptom severityDistinct underlying mechanismsChildhood EmotionsChildhood anxietySupportive parentingAnxiety treatmentParent reportBehavioral therapyRole of accommodationAnxiety severityAnxiety disordersPoor treatment outcomesTreatment outcomesSymptom severitySubsequent treatment outcomesTreatment endSignificant predictorsChildrenSPACE, Parent-Based Treatment for Childhood and Adolescent Anxiety: Clinical Case Illustration
Lebowitz E, Majdick J. SPACE, Parent-Based Treatment for Childhood and Adolescent Anxiety: Clinical Case Illustration. Journal Of Cognitive Psychotherapy 2020, 34: 107-118. DOI: 10.1891/jcpsy-d-19-00028.Peer-Reviewed Original ResearchCognitive behavioral therapyParent-based treatmentAnxiety disordersChildhood anxiety disordersClinical case illustrationParental accommodationAdolescent anxietyFamily accommodationChild anxietyChild distressBehavioral therapyParental behaviorSupportive stanceCase illustrationAnxietyEmpirical backgroundDistressEfficacious treatmentOnly interventionTheoretical foundationDisordersCase descriptionParentsChildrenChildhood
2019
Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety?
Shimshoni Y, Lebowitz ER, Brotman MA, Pine DS, Leibenluft E, Silverman WK. Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety? Behavior Therapy 2019, 51: 211-222. PMID: 32138933, PMCID: PMC7080292, DOI: 10.1016/j.beth.2019.06.005.Peer-Reviewed Original ResearchFamily Accommodation in Autism Spectrum Disorder
Feldman I, Koller J, Lebowitz ER, Shulman C, Ben Itzchak E, Zachor DA. Family Accommodation in Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3602-3610. PMID: 31134428, DOI: 10.1007/s10803-019-04078-x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFamily accommodationSpectrum disorderAnxiety disordersParent-based interventionsFamilies of childrenParents of childrenParental accommodationChild's RRBsRRB severityGreater symptom severityRepetitive behaviorsLower functioningHighlight avenuesPoor treatment outcomesRRBsSymptom severityChildrenMost participantsDisordersTreatment outcomesOCDHigh levelsFunctioningAccommodationParent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions
Lebowitz ER, Marin C, Martino A, Shimshoni Y, Silverman WK. Parent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 362-372. PMID: 30851397, PMCID: PMC6732048, DOI: 10.1016/j.jaac.2019.02.014.Peer-Reviewed Original ResearchConceptsParent-based treatmentAnxious Childhood EmotionsChildhood anxiety disordersFamily accommodationChildhood anxietyAnxiety disordersChildhood EmotionsSupportive parentingParenting stressAnxiety outcomesCognitive behavioral therapyPrimary anxiety disorderParent interventionBehavioral therapyChildren's ratingsAnxiety severityTreatment credibilityClinician-rated scalesParent treatmentParent involvementAnxietyDiagnostic InterviewEmotionsParentingIndependent evaluators
2018
Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth
Lebowitz ER, Blumberg HP, Silverman WK. Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth. Journal Of Affective Disorders 2018, 245: 806-811. PMID: 30699863, PMCID: PMC6361537, DOI: 10.1016/j.jad.2018.11.070.Peer-Reviewed Original ResearchConceptsNegative peer interactionsPeer social interactionSalivary oxytocin levelsAnxious youthPeer interactionsHigher oxytocin levelsAnxiety disordersOxytocin levelsSocial interactionSuicidal ideationSocial eventsSelf-report measuresPrimary anxiety disorderSemi-structured diagnostic interviewNegative social interactionsPeripheral oxytocin levelsSample of childrenPeer victimizationUsing Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change
Lebowitz ER, François B. Using Motion Tracking to Measure Avoidance in Children and Adults: Psychometric Properties, Associations With Clinical Characteristics, and Treatment-Related Change. Behavior Therapy 2018, 49: 853-865. PMID: 30316485, PMCID: PMC6394864, DOI: 10.1016/j.beth.2018.04.005.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral avoidanceThreat facesMotion-tracking technologyChild-rated anxiety symptomsChildhood anxiety disordersSelf-rated fearAnxiety symptom severitySpider stimuliAnxious childrenTest-retest correlationsAreas of psychopathologyState anxietyTest-retest reliabilityAnxiety symptomsAnxiety disordersTime-effective measurementsAvoidance behaviorPsychometric propertiesTreatment-related changesSymptom severityThird studySecond studyAvoidanceLarge sampleAnxiety Disorders in Children and Adolescents
Byrne S, Lebowitz E, Ollendick T, Silverman W. Anxiety Disorders in Children and Adolescents. 2018, 217-241. DOI: 10.1093/med-psych/9780190492243.003.0011.ChaptersImplications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersChildhood anxietyResearch Domain Criteria projectAnxiety disordersSocial processesMental Health's Research Domain Criteria projectNegative Valence Systems domainFronto-amygdala circuitryThreat learningPsychiatric disordersNegative valencePediatric anxietyChildren's fearsDevelopmental psychopathologyPrevalent psychiatric disordersParticular social processesAnxietyAttachment processRDoCResearch linksFearYouthTranslational approachDisordersInterdisciplinary approach