Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation
Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1607-1612. PMID: 25605929, PMCID: PMC4321293, DOI: 10.1073/pnas.1421419112.Peer-Reviewed Original ResearchConceptsSummer active stateNervous tissue functionPalmitate-induced uncouplingDifferential transcriptomicsMolecular mechanismsHibernating mammalsBrown adipose tissueBody temperatureProtein 1Ground squirrelsBiochemical analysisTorpid squirrelsHibernation seasonTissue functionActive stateUCP1 expressionHigh expressionHibernationPharmacologic analysisThermogenic proteinsAdipose tissueBrain temperatureLow body temperatureNervous systemPhysiologic phenotype