Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels
Laursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11342-11347. PMID: 27638213, PMCID: PMC5056056, DOI: 10.1073/pnas.1604269113.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAmino Acid SequenceAmino Acid SubstitutionAnimalsAnkyrin RepeatCamelusCapsaicinConserved SequenceGanglia, SpinalHEK293 CellsHot TemperatureHumansHydrogen-Ion ConcentrationIon Channel GatingMutationNeuronsSciuridaeSequence AlignmentThermotoleranceTRPV Cation ChannelsXenopusConceptsHeat toleranceCommon molecular strategyN-terminal ankyrinSingle amino acid changeSingle amino acid substitutionGround squirrelsPolymodal ion channelAmino acid changesAmino acid substitutionsRemarkable functional flexibilityFunctional conservationEcological nichesChemical cuesMammalian speciesMolecular strategiesAcid changesAcid substitutionsHeat sensitivityTransient receptor potential vanilloid 1Ion channelsOrthologsFunctional plasticitySquirrelsBactrian camelsSuch adaptation