Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury
Kirkiles-Smith NC, Harding MJ, Shepherd BR, Fader SA, Yi T, Wang Y, McNiff JM, Snyder EL, Lorber MI, Tellides G, Pober JS. Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury. Transplantation 2009, 87: 189-197. PMID: 19155972, PMCID: PMC2776641, DOI: 10.1097/tp.0b013e318192e05d.Peer-Reviewed Original ResearchConceptsT cellsImmunodeficient micePeripheral blood monuclear cellsHematopoietic stem cellsAllogeneic T cellsHuman cell engraftmentHumanized mouse modelHuman monocytes/macrophagesRole of macrophagesArterial interposition graftsMonocytes/macrophagesImmunodeficient mouse hostsStem cellsHuman skinAllograft injuryArtery graftAdoptive transferInterposition graftPeripheral bloodTransplant rejectionIntimal expansionHuman allograftsMouse modelCell engraftmentTissue graft