Pindolol augmentation in depressed patients resistant to selective serotonin reuptake inhibitors: a double-blind, randomized, controlled trial.
Perry EB, Berman RM, Sanacora G, Anand A, Lynch-Colonese K, Charney DS. Pindolol augmentation in depressed patients resistant to selective serotonin reuptake inhibitors: a double-blind, randomized, controlled trial. The Journal Of Clinical Psychiatry 2004, 65: 238-43. PMID: 15003079, DOI: 10.4088/jcp.v65n0215.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAdultAgedConnecticutCross-Over StudiesDepressive Disorder, MajorDouble-Blind MethodDrug ResistanceDrug Therapy, CombinationFemaleFluoxetineHospitals, VeteransHumansMaleMiddle AgedParoxetinePersonality InventoryPindololSelective Serotonin Reuptake InhibitorsSertralineTreatment OutcomeVeteransConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsPindolol augmentationMajor depressive disorderControl groupReuptake inhibitorsDepressed patientsDepressive disorderTreatment-resistant depressed patientsDSM-IV major depressive disorderEfficacy of pindololPartial response rateTreatment-resistant patientsPrimary outcome measureHAM-D scoresHamilton Rating ScaleSSRI monotherapyAdequate trialClinical responseAntidepressant responseSSRI administrationWeek 4Outcome measuresWeek 6Insufficient response