2024
Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2012
Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice
Martín-López E, Corona R, López-Mascaraque L. Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice. Frontiers In Neuroanatomy 2012, 6: 15. PMID: 22661929, PMCID: PMC3357593, DOI: 10.3389/fnana.2012.00015.Peer-Reviewed Original ResearchAccessory olfactory bulbOlfactory bulbReeler miceCell phenotypeAdaptor protein Dab1Early postnatal developmentGranular cell layerOlfactory systemAccessory olfactory systemGlial cell typesMain olfactory systemWT miceReelin deficiencyGlial markersGranular neuronsPostnatal developmentLearning deficitsMiceCell layerFirst relayCell typesEarly embryonic stagesBulbPhenotypeGenetic background
2010
Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb)
Blanchart A, Martín‐López E, De Carlos JA, López‐Mascaraque L. Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb). Glia 2010, 59: 278-292. PMID: 21125652, DOI: 10.1002/glia.21100.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBromodeoxyuridineCell MovementCell ProliferationCells, CulturedEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalGene Transfer TechniquesGreen Fluorescent ProteinsMiceNerve Tissue ProteinsNeurogliaNeuronsOlfactory BulbOlfactory PathwaysPregnancyProsencephalonConceptsMigratory massCell populationsOlfactory axonsDifferent neural cell populationsOlfactory placodeOlfactory Ensheathing CellsCentral nervous systemLater postnatal stagesEmbryonic day 11Glial markersRetroviral injectionCNS neuronsNeural cell populationsGlomerular layerOlfactory nerveOlfactory bulbPeripheral contributionsNervous systemOlfactory epitheliumDifferent cell populationsDay 11Telencephalic vesiclePostnatal stagesInfected cellsOlfactory system