Featured Publications
Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure
Kribakaran S, Odriozola P, Cohodes E, McCauley S, Zacharek S, Hodges H, Haberman J, Pierre J, Gee D. Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure. Neurobiology Of Stress 2022, 21: 100497. PMID: 36532365, PMCID: PMC9755062, DOI: 10.1016/j.ynstr.2022.100497.Peer-Reviewed Original ResearchLeveraging the science of stress to promote resilience and optimize mental health interventions during adolescence
Gee DG, Sisk LM, Cohodes EM, Bryce NV. Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence. Nature Communications 2022, 13: 5693. PMID: 36171218, PMCID: PMC9519553, DOI: 10.1038/s41467-022-33416-4.Peer-Reviewed Original ResearchNeural effects of controllability as a key dimension of stress exposure
Cohodes EM, Odriozola P, Mandell JD, Caballero C, McCauley S, Zacharek SJ, Hodges HR, Haberman JT, Smith M, Thomas J, Meisner OC, Ellis CT, Hartley CA, Gee DG. Neural effects of controllability as a key dimension of stress exposure. Development And Psychopathology 2022, 35: 218-227. PMID: 35034670, DOI: 10.1017/s0954579421001498.Peer-Reviewed Original ResearchConceptsDorsal anterior insulaRight dorsal anterior insulaUncontrollable stress conditionUncontrollable stressStress exposureSex-matched participantsStressor controllabilityInitial exposureFunctional magnetic resonance imaging (fMRI) acquisitionSubsequent stress exposureNeural effectsAnterior insulaYoung adultsSubsequent stressorsPatterns of activityCross-species evidenceNeural correlatesSubsequent exposureExposureNeural underpinningsPresent studyParticipantsMagnetic resonance imaging (MRI) acquisitionAdaptive responseFMRI analysisEarly Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience
Gee DG. Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. American Journal Of Psychiatry 2021, 178: 998-1013. PMID: 34734741, DOI: 10.1176/appi.ajp.2021.21090944.Peer-Reviewed Original ResearchConceptsEarly adversityProtective factorsEffects of adversityOnset of psychopathologyPathways of riskNeurodevelopmental trajectoriesMajor risk factorAdversityMental healthNeurodevelopmental pathwaysEarly environmentPsychopathologySpecific dimensionsIntervention strategiesFuture researchRisk factorsEarly risk identificationTreatment approachesImmense burdenConceptual modelDevelopmental timingResilienceOngoing refinementRiskFactorsAssociations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study
Brieant AE, Sisk LM, Gee DG. Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. Developmental Cognitive Neuroscience 2021, 52: 101022. PMID: 34710799, PMCID: PMC8556598, DOI: 10.1016/j.dcn.2021.101022.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNegative life eventsLife eventsInternalizing symptomsAdversity exposureCortico-limbic connectivityParental acceptanceAdolescent Brain Cognitive Development (ABCD) studyLongitudinal structural equation modelLower internalizing symptomsCognitive Development StudyContext of adversityIndirect effectsSample of youthStressful childhood experiencesCortico-limbic networkStructural equation modelLater psychopathologyNeurobiological maturationInternalizing problemsABCD studyFunctional connectivityChildhood experiencesPotential protective effectPsychopathology
2024
Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure
Kribakaran S, DeCross S, Odriozola P, McLaughlin K, Gee D. Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 39368629, DOI: 10.1016/j.jaac.2024.07.928.Peer-Reviewed Original ResearchSafety signal learningInterpersonal trauma exposureTrauma exposureFunctional connectivityHippocampal activityNeural correlatesConditioned safetyFunctional magnetic resonance imaging dataAnterior hippocampal activationDevelopment of psychopathologyAnterior cingulate subregionsTask-based functional magnetic resonance imaging dataExploratory analysisMagnetic resonance imaging dataMental health sequelaeAmygdala activationAge-related associationsAnterior hippocampalContingency awarenessPTSD symptomsInhibit fearAttenuating fearCingulate subregionsSignal learningFear reductionDevelopmental neuroplasticity and adversity-related risk for psychopathology
Sisk L, Gee D. Developmental neuroplasticity and adversity-related risk for psychopathology. Neuropsychopharmacology 2024, 1-2. PMID: 39095522, DOI: 10.1038/s41386-024-01950-y.Peer-Reviewed Original ResearchIntegrating developmental neuroscience with community-engaged approaches to address mental health outcomes for housing-insecure youth: Implications for research, practice, and policy
Foster J, Hodges H, Beloborodova A, Cohodes E, Phillips M, Anderson E, Fagbenro B, Gee D. Integrating developmental neuroscience with community-engaged approaches to address mental health outcomes for housing-insecure youth: Implications for research, practice, and policy. Developmental Cognitive Neuroscience 2024, 68: 101399. PMID: 38875770, PMCID: PMC11225708, DOI: 10.1016/j.dcn.2024.101399.Peer-Reviewed Original ResearchMental healthHousing insecurityInsecure housingHealth outcomesHousing conditionsExperiences of youthMental health of childrenImprove health outcomesCommunity-engaged approachChild mental healthMental health outcomesYouth mental healthCommunity-engaged researchHealth of childrenDevelopmental neuroscience researchUnsafe housingPolicy recommendationsYouthDevelopmental neurosciencePolicyNeurobehavioral pathwaysNeural circuitryStress literatureHousingInsecurityFamilial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal studyInteractive effects of participant and stimulus race on cognitive performance in youth: Insights from the ABCD study
Rubien-Thomas E, Lin Y, Chan I, Conley M, Skalaban L, Kopp H, Adake A, Richeson J, Gee D, Baskin-Sommers A, Casey B. Interactive effects of participant and stimulus race on cognitive performance in youth: Insights from the ABCD study. Developmental Cognitive Neuroscience 2024, 67: 101393. PMID: 38838435, PMCID: PMC11214402, DOI: 10.1016/j.dcn.2024.101393.Peer-Reviewed Original ResearchOther-race facesCognitive performanceRecognition memoryFace stimuliAdolescent Brain Cognitive DevelopmentSM StudyRecognition of other-race facesSame-race facesInfluence cognitive performanceRace informationImpact cognitive performanceWhite childrenAttentional biasSame-race effectsWorking memoryWhite facesAdult samplesRacial cuesGroup differencesU.S. sampleEffects of participationStimuliDiminished recognitionInteraction effectsBlack childrenMemoryResearching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design
Gross R, Thaweethai T, Rosenzweig E, Chan J, Chibnik L, Cicek M, Elliott A, Flaherman V, Foulkes A, Witvliet M, Gallagher R, Gennaro M, Jernigan T, Karlson E, Katz S, Kinser P, Kleinman L, Lamendola-Essel M, Milner J, Mohandas S, Mudumbi P, Newburger J, Rhee K, Salisbury A, Snowden J, Stein C, Stockwell M, Tantisira K, Thomason M, Truong D, Warburton D, Wood J, Ahmed S, Akerlundh A, Alshawabkeh A, Anderson B, Aschner J, Atz A, Aupperle R, Baker F, Balaraman V, Banerjee D, Barch D, Baskin-Sommers A, Bhuiyan, Bind M, Bogie A, Bradford T, Buchbinder N, Bueler E, Bükülmez H, Casey B, Chang L, Chrisant M, Clark D, Clifton R, Clouser K, Cottrell L, Cowan K, D’Sa V, Dapretto M, Dasgupta S, Dehority W, Dionne A, Dummer K, Elias M, Esquenazi-Karonika S, Evans D, Faustino E, Fiks A, Forsha D, Foxe J, Friedman N, Fry G, Gaur S, Gee D, Gray K, Handler S, Harahsheh A, Hasbani K, Heath A, Hebson C, Heitzeg M, Hester C, Hill S, Hobart-Porter L, Hong T, Horowitz C, Hsia D, Huentelman M, Hummel K, Irby K, Jacobus J, Jacoby V, Jone P, Kaelber D, Kasmarcak T, Kluko M, Kosut J, Laird A, Landeo-Gutierrez J, Lang S, Larson C, Lim P, Lisdahl K, McCrindle B, McCulloh R, McHugh K, Mendelsohn A, Metz T, Miller J, Mitchell E, Morgan L, Müller-Oehring E, Nahin E, Neale M, Ness-Cochinwala M, Nolan S, Oliveira C, Osakwe O, Oster M, Payne R, Portman M, Raissy H, Randall I, Rao S, Reeder H, Rosas J, Russell M, Sabati A, Sanil Y, Sato A, Schechter M, Selvarangan R, Tejtel S, Shakti D, Sharma K, Squeglia L, Srivastava S, Stevenson M, Szmuszkovicz J, Talavera-Barber M, Teufel R, Thacker D, Trachtenberg F, Udosen M, Warner M, Watson S, Werzberger A, Weyer J, Wood M, Yin H, Zempsky W, Zimmerman E, Dreyer B, Consortium O. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. PLOS ONE 2024, 19: e0285635. PMID: 38713673, PMCID: PMC11075869, DOI: 10.1371/journal.pone.0285635.Peer-Reviewed Original ResearchConceptsYoung adultsClinical courseAdolescent Brain Cognitive DevelopmentCaregiver-child pairsLong-term outcomesObservational cohort studyOutcomes of COVID-19De novo cohortAdolescent Brain Cognitive Development StudySociodemographic correlatesCommunity partnersBaseline assessmentLongitudinal follow-upPotential therapeutic interventionsPediatric protocolsCohort studyCollaborative partnershipsProspective cohortFollow-upStudy protocolFederal partnersNIH Researching COVIDLong-term outcomes of COVID-19Enhanced recoveryData collectionFuture Directions for Community-Engaged Research in Clinical Psychological Science with Youth
Giusto A, Triplett N, Foster J, Gee D. Future Directions for Community-Engaged Research in Clinical Psychological Science with Youth. Journal Of Clinical Child & Adolescent Psychology 2024, 53: 503-522. PMID: 38830059, PMCID: PMC11258858, DOI: 10.1080/15374416.2024.2359650.Peer-Reviewed Original ResearchClinical psychological scienceClinical scienceMental health problemsBurden of mental health problemsYouth mental healthPsychological scienceMental healthCommunity-engaged researchExperimental controlYouthFuture directionsClinical scientistsModes of inquiryFamily perspectiveCommunity engagementSustainability outcomesCommunity-engagedHealth problemsPublic healthChanges in Frontoamygdala Circuitry Associated With a Parent-Focused Intervention for Pediatric Anxiety Disorders
Gee D, Gunther K, Petrie D, Kitt E, Keding T, Broussard A, Zacharek S, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Odriozola P, Marin C, Silverman W, Lebowitz E. Changes in Frontoamygdala Circuitry Associated With a Parent-Focused Intervention for Pediatric Anxiety Disorders. Biological Psychiatry 2024, 95: s44. DOI: 10.1016/j.biopsych.2024.02.110.Peer-Reviewed Original ResearchLeveraging multivariate approaches to advance the science of early-life adversity
Brieant A, Sisk L, Keding T, Cohodes E, Gee D. Leveraging multivariate approaches to advance the science of early-life adversity. Child Abuse & Neglect 2024, 106754. PMID: 38521731, PMCID: PMC11416566, DOI: 10.1016/j.chiabu.2024.106754.Peer-Reviewed Original ResearchResponding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2023
Parental Assistance with Children’s Extrinsic Emotion Regulation across Development
Cohodes E, Gee D. Parental Assistance with Children’s Extrinsic Emotion Regulation across Development. 2023, 149-165. DOI: 10.1017/9781009304368.012.Peer-Reviewed Original ResearchValidation of an Electronic Self-Administered Version of the Dimensional Inventory of Stress and Trauma Across the Lifespan in a Large Sample of Young Adults
Cohodes E, Mandell J, Notti M, Schroeder M, Ababio R, McCauley S, Pierre J, Hodges H, Gee D. Validation of an Electronic Self-Administered Version of the Dimensional Inventory of Stress and Trauma Across the Lifespan in a Large Sample of Young Adults. Psychological Trauma Theory Research Practice And Policy 2023 PMID: 37956029, PMCID: PMC11089071, DOI: 10.1037/tra0001606.Peer-Reviewed Original ResearchLeveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity
Gee D, Cohodes E. Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity. Development And Psychopathology 2023, 35: 2168-2185. PMID: 37929292, PMCID: PMC10872788, DOI: 10.1017/s0954579423001128.Peer-Reviewed Original ResearchCorticolimbic circuitryEmotional functioningYouth emotional functioningEmergence of psychopathologyFavorable mental health outcomesMental health outcomesYouth mental healthEmotion regulationDevelopmental neuroscienceLine of researchNeural mechanismsEarly attachmentEmotional learningEarly adversityFoster resilienceStress reactivityAdversitySensitive periodMental healthClinical interventionsResilienceFunctioningClinical implicationsYouthMajor risk factorMeta-Analytic Evidence for Association of Adversity With Brain Function
Gee D, Brieant A. Meta-Analytic Evidence for Association of Adversity With Brain Function. JAMA Network Open 2023, 6: e2339966. PMID: 37910108, DOI: 10.1001/jamanetworkopen.2023.39966.Peer-Reviewed Original Research
2022
Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratio