2020
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal models
2019
Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
Meyer HC, Odriozola P, Cohodes EM, Mandell JD, Li A, Yang R, Hall BS, Haberman JT, Zacharek SJ, Liston C, Lee FS, Gee DG. Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26970-26979. PMID: 31822612, PMCID: PMC6936350, DOI: 10.1073/pnas.1910481116.Peer-Reviewed Original ResearchCompound cueAnxiety disordersPrelimbic cortexSafety signal learningCurrent evidence-based treatmentsVentromedial prefrontal cortexCognitive behavioral therapyAlternative neural mechanismVentral hippocampal neuronsPresence of threatNeural activity patternsEvidence-based treatmentsAnxious individualsThreat cuesEvidence-based interventionsSafety learningFear extinctionVentral hippocampusThreat responsesSignal learningNeural mechanismsBehavioral therapyInhibition paradigmPrefrontal cortexHippocampal responses