Featured Publications
Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience
Gee DG. Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. American Journal Of Psychiatry 2021, 178: 998-1013. PMID: 34734741, DOI: 10.1176/appi.ajp.2021.21090944.Peer-Reviewed Original ResearchConceptsEarly adversityProtective factorsEffects of adversityOnset of psychopathologyPathways of riskNeurodevelopmental trajectoriesMajor risk factorAdversityMental healthNeurodevelopmental pathwaysEarly environmentPsychopathologySpecific dimensionsIntervention strategiesFuture researchRisk factorsEarly risk identificationTreatment approachesImmense burdenConceptual modelDevelopmental timingResilienceOngoing refinementRiskFactors
2023
Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity
Gee D, Cohodes E. Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity. Development And Psychopathology 2023, 35: 2168-2185. PMID: 37929292, PMCID: PMC10872788, DOI: 10.1017/s0954579423001128.Peer-Reviewed Original ResearchCorticolimbic circuitryEmotional functioningYouth emotional functioningEmergence of psychopathologyFavorable mental health outcomesMental health outcomesYouth mental healthEmotion regulationDevelopmental neuroscienceLine of researchNeural mechanismsEarly attachmentEmotional learningEarly adversityFoster resilienceStress reactivityAdversitySensitive periodMental healthClinical interventionsResilienceFunctioningClinical implicationsYouthMajor risk factor
2020
Caregiving influences on emotional learning and regulation: applying a sensitive period model
Gee DG. Caregiving influences on emotional learning and regulation: applying a sensitive period model. Current Opinion In Behavioral Sciences 2020, 36: 177-184. PMID: 33718534, PMCID: PMC7945765, DOI: 10.1016/j.cobeha.2020.11.003.Peer-Reviewed Original ResearchEmotional learningSensitive period modelCorticolimbic circuitrySensitive periodCross-species evidenceExperience-dependent mechanismsEmotional developmentDevelopmental differencesEarly adversityDifferential associationsAdversityLearningConceptual modelDevelopmental timingExperienceSpecific ageAdolescenceCircuitryMaltreatmentChildhoodInfancyAssociationEvidenceCentral roleDifferences
2013
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.Peer-Reviewed Original ResearchConceptsMaternal deprivationAmygdala-mPFC connectivityEarly adversityEarly maternal deprivationAmygdala-prefrontal connectivityMature connectivityRodent modelsReduced anxietyAdolescent phenotypeHormone cortisolEarly developmental emergenceStress-induced modificationsDeprivationComparison childrenConnectivity patternsChildrenDevelopmental emergenceAnxietyPhenotypeInstitutionalized youthAmygdalaAdversityCortisolOntogenetic adaptation