Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.Peer-Reviewed Original ResearchConceptsMaternal deprivationAmygdala-mPFC connectivityEarly adversityEarly maternal deprivationAmygdala-prefrontal connectivityMature connectivityRodent modelsReduced anxietyAdolescent phenotypeHormone cortisolEarly developmental emergenceStress-induced modificationsDeprivationComparison childrenConnectivity patternsChildrenDevelopmental emergenceAnxietyPhenotypeInstitutionalized youthAmygdalaAdversityCortisolOntogenetic adaptation