2023
Everglades virus: an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA
Burkett-Cadena N, Fish D, Weaver S, Vittor A. Everglades virus: an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA. Journal Of Medical Entomology 2023, 60: 1149-1164. PMID: 37862065, PMCID: PMC10645373, DOI: 10.1093/jme/tjad070.Peer-Reviewed Original ResearchConceptsEverglades virusEncephalitis virusCases of meningitisCotton rat Sigmodon hispidusHigh natural infection rateEpidemic strainsNatural infection rateInfection rateWidespread transmissionAbundance of AedesNatural infectionSubtype IISubtypesFrequent feedingFrequency of contactCertain mosquitoesVector competenceVirusHuman diseasesRodentsVertebrate hostsA ticking time bomb hidden in plain sight
Narasimhan S, Fish D, Pedra J, Pal U, Fikrig E. A ticking time bomb hidden in plain sight. Science Translational Medicine 2023, 15: eadi7829. PMID: 37851823, DOI: 10.1126/scitranslmed.adi7829.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Borrelia miyamotoi: An Emerging Tick-Borne Pathogen
Wormser GP, Shapiro ED, Fish D. Borrelia miyamotoi: An Emerging Tick-Borne Pathogen. The American Journal Of Medicine 2018, 132: 136-137. PMID: 30144406, DOI: 10.1016/j.amjmed.2018.08.012.Peer-Reviewed Original Research
2017
Human rickettsial pathogen modulates arthropod organic anion transporting polypeptide and tryptophan pathway for its survival in ticks
Taank V, Dutta S, Dasgupta A, Steeves TK, Fish D, Anderson JF, Sultana H, Neelakanta G. Human rickettsial pathogen modulates arthropod organic anion transporting polypeptide and tryptophan pathway for its survival in ticks. Scientific Reports 2017, 7: 13256. PMID: 29038575, PMCID: PMC5643405, DOI: 10.1038/s41598-017-13559-x.Peer-Reviewed Original ResearchCharacterization of Three New Insect-Specific Flaviviruses: Their Relationship to the Mosquito-Borne Flavivirus Pathogens
Guzman H, Contreras-Gutierrez MA, da Rosa A, Nunes MRT, Cardoso JF, Popov VL, Young KI, Savit C, Wood TG, Widen SG, Watts DM, Hanley KA, Perera D, Fish D, Vasilakis N, Tesh RB. Characterization of Three New Insect-Specific Flaviviruses: Their Relationship to the Mosquito-Borne Flavivirus Pathogens. American Journal Of Tropical Medicine And Hygiene 2017, 98: 410-419. PMID: 29016330, PMCID: PMC5929187, DOI: 10.4269/ajtmh.17-0350.Peer-Reviewed Original ResearchLyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control
Kilpatrick AM, Dobson ADM, Levi T, Salkeld DJ, Swei A, Ginsberg HS, Kjemtrup A, Padgett KA, Jensen PM, Fish D, Ogden NH, Diuk-Wasser MA. Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. Philosophical Transactions Of The Royal Society B Biological Sciences 2017, 372: 20160117. PMID: 28438910, PMCID: PMC5413869, DOI: 10.1098/rstb.2016.0117.Peer-Reviewed Original ResearchConceptsNorth AmericaLyme disease ecologyDeer abundanceDifferent habitatsVector-borne zoonotic diseaseTemperate regionsDisease ecologyLyme disease preventionHost speciesDisease riskTick abundanceKnowledge gapsTemporal variationReservoir competenceCommon tick-borne diseaseEcologySubstantial uncertaintyAbundanceHost communitiesTick-borne diseaseTick populationsCritical gapAmericaAreas of consensusDisease prevention
2016
A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control
Alfaro-Murillo JA, Parpia AS, Fitzpatrick MC, Tamagnan JA, Medlock J, Ndeffo-Mbah ML, Fish D, Ávila-Agüero ML, Marín R, Ko AI, Galvani AP. A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. PLOS Neglected Tropical Diseases 2016, 10: e0004743. PMID: 27205899, PMCID: PMC4874682, DOI: 10.1371/journal.pntd.0004743.Peer-Reviewed Original ResearchConceptsGuillain-Barré syndromeZika infectionHealth burdenVirus controlRisk of microcephalyDirect medical costsCost-effectiveness toolsCurrent Zika outbreakGBS casesMedical costsZika casesZika virusMicrocephalyIncidence dataCountry of implementationZika outbreakInfectionInterventionBurdenInforming PolicyDALYsCountry-specific settingsOutbreakMosquitoesPregnancyEvaluating the effectiveness of localized control strategies to curtail chikungunya
Ndeffo-Mbah ML, Durham DP, Skrip LA, Nsoesie EO, Brownstein JS, Fish D, Galvani AP. Evaluating the effectiveness of localized control strategies to curtail chikungunya. Scientific Reports 2016, 6: 23997. PMID: 27045523, PMCID: PMC4820747, DOI: 10.1038/srep23997.Peer-Reviewed Original ResearchConceptsAcute febrile phaseChronic joint painRe-emerging arbovirusOutbreak of chikungunyaJoint painFebrile phaseSymptomatic casesChikungunya casesChikungunya outbreakTropical diseasesDiseaseAlbopictus mosquitoesDisease surveillanceChikungunyaTransmission dynamicsPrimary measureVector control effortsAedes aegyptiMosquito movementContainment strategiesOutbreakSubsequent spreadVector controlMosquitoesPain
2015
Spatial and Temporal Clustering of Chikungunya Virus Transmission in Dominica
Nsoesie EO, Ricketts RP, Brown HE, Fish D, Durham DP, Mbah M, Christian T, Ahmed S, Marcellin C, Shelly E, Owers K, Wenzel N, Galvani AP, Brownstein JS. Spatial and Temporal Clustering of Chikungunya Virus Transmission in Dominica. PLOS Neglected Tropical Diseases 2015, 9: e0003977. PMID: 26274813, PMCID: PMC4537218, DOI: 10.1371/journal.pntd.0003977.Peer-Reviewed Original ResearchAssociation between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States
Barbour AG, Bunikis J, Fish D, Hanincová K. Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States. Parasites & Vectors 2015, 8: 299. PMID: 26024881, PMCID: PMC4459683, DOI: 10.1186/s13071-015-0903-5.Peer-Reviewed Original ResearchConceptsBody sizeLarge-sized mammalsMedium-sized mammalsDifferent mammalian speciesEastern North AmericaSpecies-specific PCRLyme disease agentSmall mammalsMammalian speciesWhite-footed mouseCommon raccoonSized mammalsMammalsBorrelia burgdorferiPine volesBody massGrey squirrelsVirginia opossumReservoir competenceEastern chipmunksIxodes scapularis ticksDisease agentsStriped skunksSpeciesNymphal Ixodes scapularis ticksBorrelia miyamotoi infection in nature and in humans
Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clinical Microbiology And Infection 2015, 21: 631-639. PMID: 25700888, PMCID: PMC4470780, DOI: 10.1016/j.cmi.2015.02.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsB. miyamotoi infectionMiyamotoi infectionClinical manifestationsB. miyamotoiLyme diseaseBorrelia miyamotoi infectionAcute febrile illnessCommon clinical manifestationsBlood smear examinationPublic health importanceHuman granulocytic anaplasmosisFever group spirochetesFebrile illnessAntibiotic therapyDisease groupEtiologic diagnosisSevere diseaseSmear examinationIxodes persulcatus ticksHealth importanceInfectionHuman casesGranulocytic anaplasmosisBorrelia miyamotoiDisease
2014
Long-term in vitro cultivation of Borrelia miyamotoi
Margos G, Stockmeier S, Hizo-Teufel C, Hepner S, Fish D, Dautel H, Sing A, Dzaferovic E, Rieger M, Jungnick S, Binder K, Straubinger RK, Fingerle V. Long-term in vitro cultivation of Borrelia miyamotoi. Ticks And Tick-borne Diseases 2014, 6: 181-184. PMID: 25561082, DOI: 10.1016/j.ttbdis.2014.12.001.Peer-Reviewed Original ResearchBorrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC
Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D, . Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 1183-1190. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.Peer-Reviewed Original ResearchConceptsB. burgdorferiInfectious Diseases journal - CDCSeroprevalence of IgGB. burgdorferi antigensLyme disease endemic areaDisease-endemic areasAntibody testingHealthy personsLyme diseaseSerum samplesSeroprevalenceBurgdorferiInfectionSame tickUnited StatesSensu latoArea residentsPersonsBorrelia spSeroreactivityIgGAntigenDiseaseSerumMonitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC
Diuk-Wasser MA, Liu Y, Steeves TK, Folsom-O'Keefe C, Dardick KR, Lepore T, Bent SJ, Usmani-Brown S, Telford SR, Fish D, Krause PJ. Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA - Volume 20, Number 2—February 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 225-231. PMID: 24447577, PMCID: PMC3901474, DOI: 10.3201/eid2002.130644.Peer-Reviewed Original ResearchConceptsHuman babesiosisInfectious Diseases journal - CDCProtozoan Babesia microtiDisease-endemic areasTick-borne diseaseBabesiosis-endemic areasSame tick vectorInfection rateInfection ratioTick infection ratesLyme diseaseBabesia microtiHuman casesDiseaseDisease expansionBabesiosisReservoir hostsTick vectorHuman diseasesSurveillanceClose associationGut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete
Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E. Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.Peer-Reviewed Original ResearchConceptsPeritrophic matrixTranscription factor signal transducerPathogen colonizationLyme disease spirochete Borrelia burgdorferiActivator of transcriptionGut microbiotaArthropod gutsSignal transducerLyme disease spirocheteFunctional linkArthropod vectorsMajor vectorKey glycoproteinsHuman pathogensSpirochete Borrelia burgdorferiGut epitheliumIxodes scapularis ticksColonizationGut epithelial barrierMicrobiotaExpressionGut lumenScapularis ticksBorrelia burgdorferiEpithelial barrier
2013
Borrelia miyamotoi: More lessons on disease discovery.
Fish D. Borrelia miyamotoi: More lessons on disease discovery. Annals Of Internal Medicine 2013, 159: 648. PMID: 24189601, DOI: 10.7326/0003-4819-159-9-201311050-00018.Peer-Reviewed Original ResearchQuantitative PCR for Detection of Babesia microti in Ixodes scapularis Ticks and in Human Blood
Rollend L, Bent SJ, Krause PJ, Usmani-Brown S, Steeves TK, States SL, Lepore T, Ryan R, Dias F, Mamoun C, Fish D, Diuk-Wasser MA. Quantitative PCR for Detection of Babesia microti in Ixodes scapularis Ticks and in Human Blood. Vector-Borne And Zoonotic Diseases 2013, 13: 784-790. PMID: 24107203, PMCID: PMC3822370, DOI: 10.1089/vbz.2011.0935.Peer-Reviewed Original ResearchConceptsB. microti DNAIxodes scapularis ticksHuman babesiosisScapularis ticksBabesia microtiQuantitative PCRViral-like illnessB. microti infectionAcute infectionBlood transfusionDisparate incidenceMicroti infectionProlonged illnessBlood supplyI. scapularis ticksBlood samplesEpidemiological surveillanceInfected peopleBorrelia miyamotoiB. microtiBorrelia burgdorferiHuman blood samplesI. scapularis nymphsAnaplasma phagocytophilumSpecific quantitative PCRHuman Borrelia miyamotoi Infection in the United States
Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi Infection in the United States. New England Journal Of Medicine 2013, 368: 291-293. PMID: 23323920, PMCID: PMC3934646, DOI: 10.1056/nejmc1215469.Peer-Reviewed Original Research
2012
Geographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States
Pepin KM, Eisen RJ, Mead PS, Piesman J, Fish D, Hoen AG, Barbour AG, Hamer S, Diuk-Wasser MA. Geographic Variation in the Relationship between Human Lyme Disease Incidence and Density of Infected Host-Seeking Ixodes scapularis Nymphs in the Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 1062-1071. PMID: 22665620, PMCID: PMC3366524, DOI: 10.4269/ajtmh.2012.11-0630.Peer-Reviewed Original ResearchHuman Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States
Diuk-Wasser MA, Hoen AG, Cislo P, Brinkerhoff R, Hamer SA, Rowland M, Cortinas R, Vourc'h G, Melton F, Hickling GJ, Tsao JI, Bunikis J, Barbour AG, Kitron U, Piesman J, Fish D. Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 320-327. PMID: 22302869, PMCID: PMC3269287, DOI: 10.4269/ajtmh.2012.11-0395.Peer-Reviewed Original ResearchConceptsLyme diseaseHuman riskSpread of infectionHuman infection riskBorrelia burgdorferi sensu strictoRisk factorsBurgdorferi sensu strictoInfection riskTick-borne pathogensLyme disease agentPrevention effortsInfectionBorrelia burgdorferiConfidence intervalsB. burgdorferiInfected nymphsRiskDiseaseRisk focusBurgdorferiUnited StatesDisease agentsHost-seeking nymphsI. scapularis populationsDiagnosis