2010
Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii
Margos G, Hojgaard A, Lane R, Cornet M, Fingerle V, Rudenko N, Ogden N, Aanensen D, Fish D, Piesman J. Multilocus sequence analysis of Borrelia bissettii strains from North America reveals a new Borrelia species, Borrelia kurtenbachii. Ticks And Tick-borne Diseases 2010, 1: 151-158. PMID: 21157575, PMCID: PMC3000690, DOI: 10.1016/j.ttbdis.2010.09.002.Peer-Reviewed Original ResearchConceptsMultilocus sequence analysisSequence analysisGenetic distance analysisNew Borrelia speciesBorrelia speciesDifferent transmission cyclesBorrelia bissettiiB. bissettiiLinear chromosomesPhylogenetic relationshipsEcological differencesConcatenated sequencesPhylogenetic analysisHousekeeping genesVector associationNorth AmericaInternal fragmentDistance analysisBorrelia genospeciesB. carolinensisReservoir hostsTransmission cycleI. spinipalpisIxodes pacificusRelated clusters
2008
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
Margos G, Gatewood A, Aanensen D, Hanincová K, Terekhova D, Vollmer S, Cornet M, Piesman J, Donaghy M, Bormane A, Hurn M, Feil E, Fish D, Casjens S, Wormser G, Schwartz I, Kurtenbach K. MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 8730-8735. PMID: 18574151, PMCID: PMC2435589, DOI: 10.1073/pnas.0800323105.Peer-Reviewed Original ResearchConceptsHousekeeping genesIntergenic spacerPopulation structureGeographic population structureChromosomal housekeeping genesMultilocus sequence typing (MLST) schemeB. burgdorferiPhylogenetic signalNorth AmericaEvolutionary relationshipsSequence typing schemeEvolutionary trajectoriesIGS locusSequence dataMLST schemeCultured isolatesGenesBorrelia burgdorferiOuter surface protein CMLST dataDistinct populationsSurface protein CBacterium Borrelia burgdorferiEuropean populationsVector-borne diseases