1996
Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine
Ma J, Hine P, Clough E, Fish D, Coughlin R, Beltz G, Shew M. Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine. Vaccine 1996, 14: 1366-1374. PMID: 9004447, DOI: 10.1016/s0264-410x(96)00045-x.Peer-Reviewed Original ResearchConceptsCanine Lyme disease vaccineLyme disease vaccineDisease vaccineGeometric mean antibody titersInjection site swellingMean antibody titersTypical clinical signsMonths postchallengeVaccination timeSecond vaccinationBorrelial antigensSpirochetal antigensAntibody titersProtective efficacyControl beaglesAdverse reactionsVaccinated dogsClinical signsImmunological memoryLocal reactionsAntibody productionNormal beaglesVaccinatesLyme diseaseOsp ATiming of Ixodes scapularis (Acari: Ixodidae) Oviposition and arval Activity in Southern New York
Daniels T, Falco R, Curran K, Fish D. Timing of Ixodes scapularis (Acari: Ixodidae) Oviposition and arval Activity in Southern New York. Journal Of Medical Entomology 1996, 33: 140-147. PMID: 8906918, DOI: 10.1093/jmedent/33.1.140.Peer-Reviewed Original Research
1995
Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21
Coughlin R, Fish D, Mather T, Ma J, Pavia C, Bulger P. Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21. The Journal Of Infectious Diseases 1995, 171: 1049-1052. PMID: 7706788, DOI: 10.1093/infdis/171.4.1049.Peer-Reviewed Original ResearchConceptsProtection of dogsAdjuvant QS21Vaccinated dogsControl dogsLyme diseaseIxodes scapularisOuter surface protein ABorrelia burgdorferi infectionB. burgdorferiSurface protein ADogsBurgdorferi infectionVaccineScapularisQS21InfectionDiseaseProtectionXenodiagnosisBurgdorferiProtein AFeverSymptomsLimp
1994
Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi).
Mather T, Fish D, Coughlin R. Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi). Journal Of The American Veterinary Medical Association 1994, 205: 186-8. PMID: 7928571, DOI: 10.2460/javma.1994.205.02.186.Peer-Reviewed Original ResearchConceptsDirect fluorescent antibodyBurgdorferi-infected ticksInfected adult ticksAdult deer ticksChallenge exposureImmature ticksInfected dogsLyme diseaseInfected ticksDogsBorrelia burgdorferiFluorescent antibodyDeer ticksBlood mealCompetent reservoirsAdult ticksHuman riskExposureLarval ticksReservoir competenceTicksDiseaseWeeksAntibodies
1993
The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area.
Falco R, Smith H, Fish D, Mojica B, Bellinger M, Harris H, Hechemy K. The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area. American Journal Of Public Health 1993, 83: 1305-1310. PMID: 8363007, PMCID: PMC1694954, DOI: 10.2105/ajph.83.9.1305.Peer-Reviewed Original ResearchConceptsCanine exposureEnzyme-linked immunosorbentLyme diseaseBorrelia burgdorferiLyme disease endemic areaIntensity of exposureHuman Lyme diseaseDistribution of exposureSeroprevalence ratesBlood samplesEndemic areasEquivocal samplesResident dogsWestchester CountyDiseaseMean numberCausative agentSignificant differencesExposureImmunosorbentDogsHuman riskBurgdorferiSimilar patternClose associationCanine Exposure to Borrelia burgdorferi and Prevalence of Ixodes dammini (Acari: Ixodidae) on Deer as a Measure of Lyme Disease Risk in the Northeastern United States
Daniels T, Fish D, Levine J, Greco M, Eaton A, Padgett P, Lapointe D. Canine Exposure to Borrelia burgdorferi and Prevalence of Ixodes dammini (Acari: Ixodidae) on Deer as a Measure of Lyme Disease Risk in the Northeastern United States. Journal Of Medical Entomology 1993, 30: 171-178. PMID: 8433324, DOI: 10.1093/jmedent/30.1.171.Peer-Reviewed Original ResearchConceptsLyme diseaseEndemic areasHuman casesPublic health workersEnzyme-linked immunosorbentCanine exposureHigh-risk countiesNonendemic areasHealth workersCanine seroprevalenceEtiologic agentDisease riskSurveillance programDiseaseBorrelia burgdorferiIxodes damminiCanine serumRegression analysisLyme disease riskPrevalenceSame countyRiskSignificant positive linear relationshipSeroprevalenceImmunosorbent
1986
SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA
Magnarelli L, Anderson J, Apperson C, Fish D, Johnson R, Chappell W. SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA. Journal Of Wildlife Diseases 1986, 22: 178-188. PMID: 3520030, DOI: 10.7589/0090-3558-22.2.178.Peer-Reviewed Original ResearchConceptsB. burgdorferiIndirect immunofluorescence testIxodes damminiDirect fluorescent antibodyTick-infested areasSerologic evidenceLeptospira infectionImmunofluorescence testEtiologic agentLyme diseaseInfected ticksSerum samplesAntibodiesI. scapularisFluorescent antibodyRabbit antibodiesI. dammini nymphsBurgdorferiAdultsSpirochetesAmericanum adultsAmblyomma americanum adultsWhite-tailed deerIxodid ticksTicks