Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds
Vora A, Taank V, Dutta SM, Anderson JF, Fish D, Sonenshine DE, Catravas JD, Sultana H, Neelakanta G. Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds. Scientific Reports 2017, 7: 44593. PMID: 28300174, PMCID: PMC5353578, DOI: 10.1038/srep44593.Peer-Reviewed Original ResearchConceptsDifferent immune backgroundsImmune backgroundImmunodeficient animalsImmunocompetent animalsAge-matched miceAntibody-blocking assaysIxodes scapularis ticksFibrinogenolytic activityD-dimerAnti-hemostatic factorsImmune defenseTick feedingScapularis ticksReduced levelsBlood feedingEngorgement weightLC-MS/MSFibrinogenolysisNovel roleAnimalsPCR analysisTicksFeeding