2017
Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds
Vora A, Taank V, Dutta SM, Anderson JF, Fish D, Sonenshine DE, Catravas JD, Sultana H, Neelakanta G. Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds. Scientific Reports 2017, 7: 44593. PMID: 28300174, PMCID: PMC5353578, DOI: 10.1038/srep44593.Peer-Reviewed Original ResearchConceptsDifferent immune backgroundsImmune backgroundImmunodeficient animalsImmunocompetent animalsAge-matched miceAntibody-blocking assaysIxodes scapularis ticksFibrinogenolytic activityD-dimerAnti-hemostatic factorsImmune defenseTick feedingScapularis ticksReduced levelsBlood feedingEngorgement weightLC-MS/MSFibrinogenolysisNovel roleAnimalsPCR analysisTicksFeeding
2012
Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations
Rollend L, Fish D, Childs JE. Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations. Ticks And Tick-borne Diseases 2012, 4: 46-51. PMID: 23238242, DOI: 10.1016/j.ttbdis.2012.06.008.Peer-Reviewed Original Research
2010
One Health approach to identify research needs in bovine and human babesioses: workshop report
Pérez de León AA, Strickman DA, Knowles DP, Fish D, Thacker E, de la Fuente J, Krause PJ, Wikel SK, Miller RS, Wagner GG, Almazán C, Hillman R, Messenger MT, Ugstad PO, Duhaime RA, Teel PD, Ortega-Santos A, Hewitt DG, Bowers EJ, Bent SJ, Cochran MH, McElwain TF, Scoles GA, Suarez CE, Davey R, Howell Freeman JM, Lohmeyer K, Li AY, Guerrero FD, Kammlah DM, Phillips P, Pound JM, the Group for Emerging Babesioses and One Health Research and Development in the U.S.. One Health approach to identify research needs in bovine and human babesioses: workshop report. Parasites & Vectors 2010, 3: 36. PMID: 20377902, PMCID: PMC2859369, DOI: 10.1186/1756-3305-3-36.Peer-Reviewed Original Research
2009
Community-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale
Fish D, Childs JE. Community-Based Prevention of Lyme Disease and Other Tick-Borne Diseases Through Topical Application of Acaricide to White-Tailed Deer: Background and Rationale. Vector-Borne And Zoonotic Diseases 2009, 9: 357-364. PMID: 19650729, DOI: 10.1089/vbz.2009.0022.Peer-Reviewed Original ResearchThe United States Department of Agriculture's Northeast Area-Wide Tick Control Project: Summary and Conclusions
Pound J, Miller J, George J, Fish D, Carroll J, Schulze T, Daniels T, Falco R, Stafford K, Mather T. The United States Department of Agriculture's Northeast Area-Wide Tick Control Project: Summary and Conclusions. Vector-Borne And Zoonotic Diseases 2009, 9: 439-448. PMID: 19650739, DOI: 10.1089/vbz.2008.0200.Peer-Reviewed Original ResearchConceptsLone star tickFree-living populationsTick-borne diseasePopulation recovery ratesAlternative food resourcesMajor environmental factorsUnited States DepartmentHost-targeted interventionsTick speciesAcorn mastEnvironment-friendly alternativeWhite-tailed deerTicksBait stationsControl projectFood resourcesEastern statesStates Department
2007
Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle
Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle. Infection And Immunity 2007, 75: 4237-4244. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/iai.00632-07.Peer-Reviewed Original ResearchConceptsB. burgdorferiSecond blood mealMurine modelSpirochete transmissionB. burgdorferi persistenceLyme borreliosisMiceB. burgdorferi strainsProtein DI. scapularisTick gutBlood mealBurgdorferi strainsSpirochete life cycleBurgdorferiGut extractsIxodes scapularisB. burgdorferi infectivityThreefold decreaseHost-specific signalsScapularisTicksBorreliosis
2006
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands
Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. Journal Of Experimental Medicine 2006, 203: 1507-1517. PMID: 16717118, PMCID: PMC2118316, DOI: 10.1084/jem.20060208.Peer-Reviewed Original ResearchConceptsA. phagocytophilum-infected miceRNA interference-mediated silencingA. phagocytophilumTick salivary proteinsI. scapularis salivary glandsRickettsia-like pathogensTick salivary glandsMammalian hostsGenus RickettsiaAnaplasma phagocytophilumGene expressionSalivary glandsIntracellular organismsArthropodsSalivary proteinsPathogensProteinPhagocytophilumExpressionTicksHuman anaplasmosisSilencingGenesOrganismsAnaplasma
2004
An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
Tsao J, Wootton J, Bunikis J, Luna M, Fish D, Barbour A. An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18159-18164. PMID: 15608069, PMCID: PMC536054, DOI: 10.1073/pnas.0405763102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiCommunicable DiseasesDisease ReservoirsEcologyGenotypeGlutathione TransferaseHumansImmunoenzyme TechniquesIxodesLipoproteinsLyme DiseaseMicePeromyscusPolymerase Chain ReactionRecombinant Fusion ProteinsTicksVaccinesConceptsWild white-footed miceTick infection prevalenceNegative control antigenReservoir host speciesVector-borne diseasesSympatric ticksField experimentDisease cycleB. burgdorferiDisease incidenceDisease agentsArthropod vectorsEcological approachAnimal reservoirsImmunization of humansMouse densityTicksHost speciesLyme disease agentInfection dynamicsHuman vaccinesPopulation structureWhite-footed miceOuter surface protein AHuman infectionsTyping of Borrelia Relapsing Fever Group Strains - Volume 10, Number 9—September 2004 - Emerging Infectious Diseases journal - CDC
Bunikis J, Tsao J, Garpmo U, Berglund J, Fish D, Barbour A. Typing of Borrelia Relapsing Fever Group Strains - Volume 10, Number 9—September 2004 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2004, 10: 1661-1664. PMID: 15498172, PMCID: PMC3320305, DOI: 10.3201/eid1009.040236.Peer-Reviewed Original Research
2002
Examination of the Borrelia burgdorferi Transcriptome in Ixodes scapularis during Feeding
Narasimhan S, Santiago F, Koski RA, Brei B, Anderson JF, Fish D, Fikrig E. Examination of the Borrelia burgdorferi Transcriptome in Ixodes scapularis during Feeding. Journal Of Bacteriology 2002, 184: 3122-3125. PMID: 12003955, PMCID: PMC135063, DOI: 10.1128/jb.184.11.3122-3125.2002.Peer-Reviewed Original ResearchConceptsBorrelia burgdorferi gene expressionB. burgdorferi genesPeriplasmic proteinsSignal transductionChromosomal genesPutative lipoproteinSubstrate transportGene expressionDifferential expressionGenesEnergy metabolismIxodes scapularis ticksGlobal analysisIxodes scapularisScapularis ticksExpressionTranscriptomeTransductionTicksProteinFeedingMetabolismScapularis
1999
Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis - Volume 5, Number 2—April 1999 - Emerging Infectious Diseases journal - CDC
Levin M, Vignes F, Fish D. Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis - Volume 5, Number 2—April 1999 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1999, 5: 204-208. PMID: 10221871, PMCID: PMC2640706, DOI: 10.3201/eid0502.990203.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAgent of HGEB. burgdorferi infectionBurgdorferi infectionInfectious Diseases journal - CDCBorrelia burgdorferiWhite-footed miceIxodes scapularis ticksWild white-footed miceDifferent prevalenceGranulocytic ehrlichiosisPrevalenceMiceScapularis ticksInfectionHost-seeking ticksNatural cycleBurgdorferiTicksAgentsEhrlichiosis
1998
Acquisition and Transmission of the Agent of Human Granulocytic Ehrlichiosis by Ixodes scapularis Ticks
Hodzic E, Fish D, Maretzki C, De Silva A, Feng S, Barthold S. Acquisition and Transmission of the Agent of Human Granulocytic Ehrlichiosis by Ixodes scapularis Ticks. Journal Of Clinical Microbiology 1998, 36: 3574-3578. PMID: 9817875, PMCID: PMC105242, DOI: 10.1128/jcm.36.12.3574-3578.1998.Peer-Reviewed Original ResearchConceptsInfected miceHuman granulocytic ehrlichiosisHGE agentIxodes scapularis ticksGranulocytic ehrlichiosisUninfected larval ticksAcquisition of infectionScapularis ticksMedian infectious doseLarval ticksNymphal ticksTick-borne transmissionC3H miceImmunodeficient miceInfectious doseMiceHuman isolatesInfectionOnset of feedingBloodEhrlichiosisPresent studyMammalian hostsCompetitive PCRTicksPrevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.
Nazario S, Das S, de Silva AM, Deponte K, Marcantonio N, Anderson JF, Fish D, Fikrig E, Kantor FS. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. American Journal Of Tropical Medicine And Hygiene 1998, 58: 780-5. PMID: 9660463, DOI: 10.4269/ajtmh.1998.58.780.Peer-Reviewed Original ResearchDensity-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae).
Levin M, Fish D. Density-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae). Journal Of Parasitology 1998, 84: 36-43. PMID: 9488335, DOI: 10.2307/3284526.Peer-Reviewed Original ResearchConceptsMice fed 2Larval Ixodes scapularis ticksIxodes scapularis ticksReplete larvaeIxodes scapularis larvaeUnattached ticksFed 2MiceScapularis ticksLarval I. scapularisEngorgement weightSolitary miceDifferent parasitesUnfed ticksTicksContinuous infestationI. scapularisGroupFeeding successTick density
1996
Duration of Tick Bites in a Lyme Disease-endemic Area
Falco R, Fish D, Piesman J. Duration of Tick Bites in a Lyme Disease-endemic Area. American Journal Of Epidemiology 1996, 143: 187-192. PMID: 8546120, DOI: 10.1093/oxfordjournals.aje.a008728.Peer-Reviewed Original Research
1994
Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi).
Mather T, Fish D, Coughlin R. Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi). Journal Of The American Veterinary Medical Association 1994, 205: 186-8. PMID: 7928571, DOI: 10.2460/javma.1994.205.02.186.Peer-Reviewed Original ResearchConceptsDirect fluorescent antibodyBurgdorferi-infected ticksInfected adult ticksAdult deer ticksChallenge exposureImmature ticksInfected dogsLyme diseaseInfected ticksDogsBorrelia burgdorferiFluorescent antibodyDeer ticksBlood mealCompetent reservoirsAdult ticksHuman riskExposureLarval ticksReservoir competenceTicksDiseaseWeeksAntibodies
1993
Reduced Abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme Disease Risk by Deer Exclusion
Daniels T, Fish D, Schwartz I. Reduced Abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme Disease Risk by Deer Exclusion. Journal Of Medical Entomology 1993, 30: 1043-1049. PMID: 8271246, DOI: 10.1093/jmedent/30.6.1043.Peer-Reviewed Original Research
1991
Evaluation of Host-Targeted Acaricide for Reducing Risk of Lyme Disease in Southern New York State
Daniels T, Fish D, Falco R. Evaluation of Host-Targeted Acaricide for Reducing Risk of Lyme Disease in Southern New York State. Journal Of Medical Entomology 1991, 28: 537-543. PMID: 1941916, DOI: 10.1093/jmedent/28.4.537.Peer-Reviewed Original ResearchConceptsLyme diseasePermethrin-treated cottonDiseaseMiceBorrelia burgdorferiSignificant decreaseCausative agentIxodes dammini SpielmanI. damminiTreatment sitesWhite-footed miceTreatmentHost-seeking ticksFirst yearProportion of ticksSouthern New York StateRiskTreatment areaSpirochetesNew York StateWestchester CountyYearsDensity of nymphsTicksControl area
1989
Potential for exposure to tick bites in recreational parks in a Lyme disease endemic area.
Falco R, Fish D. Potential for exposure to tick bites in recreational parks in a Lyme disease endemic area. American Journal Of Public Health 1989, 79: 12-5. PMID: 2909174, PMCID: PMC1349459, DOI: 10.2105/ajph.79.1.12.Peer-Reviewed Original Research
1986
SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA
Magnarelli L, Anderson J, Apperson C, Fish D, Johnson R, Chappell W. SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA. Journal Of Wildlife Diseases 1986, 22: 178-188. PMID: 3520030, DOI: 10.7589/0090-3558-22.2.178.Peer-Reviewed Original ResearchConceptsB. burgdorferiIndirect immunofluorescence testIxodes damminiDirect fluorescent antibodyTick-infested areasSerologic evidenceLeptospira infectionImmunofluorescence testEtiologic agentLyme diseaseInfected ticksSerum samplesAntibodiesI. scapularisFluorescent antibodyRabbit antibodiesI. dammini nymphsBurgdorferiAdultsSpirochetesAmericanum adultsAmblyomma americanum adultsWhite-tailed deerIxodid ticksTicks