2014
Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States
Dunn JM, Krause PJ, Davis S, Vannier EG, Fitzpatrick MC, Rollend L, Belperron AA, States SL, Stacey A, Bockenstedt LK, Fish D, Diuk-Wasser MA. Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States. PLOS ONE 2014, 9: e115494. PMID: 25545393, PMCID: PMC4278703, DOI: 10.1371/journal.pone.0115494.Peer-Reviewed Original ResearchConceptsB. microtiB. burgdorferiBabesia microtiLyme diseaseRespective causative agentsSpread of babesiosisI. scapularis larvaeInfected micePrimary reservoir hostHigh prevalenceLeucopus miceMiceHuman babesiosisBorrelia burgdorferiLaboratory dataLarval burdenCausative agentMicrotiBurgdorferiCoinfectionReservoir hostsDiseaseR0 modelBasic reproduction numberEnzootic cycleBorrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC
Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D, . Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States - Volume 20, Number 7—July 2014 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2014, 20: 1183-1190. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.Peer-Reviewed Original ResearchConceptsB. burgdorferiInfectious Diseases journal - CDCSeroprevalence of IgGB. burgdorferi antigensLyme disease endemic areaDisease-endemic areasAntibody testingHealthy personsLyme diseaseSerum samplesSeroprevalenceBurgdorferiInfectionSame tickUnited StatesSensu latoArea residentsPersonsBorrelia spSeroreactivityIgGAntigenDiseaseSerum
2012
Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations
Rollend L, Fish D, Childs JE. Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: A summary of the literature and recent observations. Ticks And Tick-borne Diseases 2012, 4: 46-51. PMID: 23238242, DOI: 10.1016/j.ttbdis.2012.06.008.Peer-Reviewed Original ResearchHuman Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States
Diuk-Wasser MA, Hoen AG, Cislo P, Brinkerhoff R, Hamer SA, Rowland M, Cortinas R, Vourc'h G, Melton F, Hickling GJ, Tsao JI, Bunikis J, Barbour AG, Kitron U, Piesman J, Fish D. Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States. American Journal Of Tropical Medicine And Hygiene 2012, 86: 320-327. PMID: 22302869, PMCID: PMC3269287, DOI: 10.4269/ajtmh.2012.11-0395.Peer-Reviewed Original ResearchConceptsLyme diseaseHuman riskSpread of infectionHuman infection riskBorrelia burgdorferi sensu strictoRisk factorsBurgdorferi sensu strictoInfection riskTick-borne pathogensLyme disease agentPrevention effortsInfectionBorrelia burgdorferiConfidence intervalsB. burgdorferiInfected nymphsRiskDiseaseRisk focusBurgdorferiUnited StatesDisease agentsHost-seeking nymphsI. scapularis populationsDiagnosisPredicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease
Tsao K, Fish D, Galvani AP. Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease. Vector-Borne And Zoonotic Diseases 2012, 12: 544-551. PMID: 22251312, DOI: 10.1089/vbz.2011.0731.Peer-Reviewed Original ResearchConceptsMice vaccinationTick biteB. burgdorferi transmissionLyme disease preventionTick blood mealVaccination outcomesHuman riskVaccination effortsDisease preventionLyme diseaseVaccinationInfection prevalenceBorrelia burgdorferiMiceWildlife vaccinationB. burgdorferiCausative agentPredicted outcomeBlood mealVector ticksBiteOutcomesBurgdorferiRiskWildlife reservoirs
2009
Effects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens
Hoen A, Rollend L, Papero M, Carroll J, Daniels T, Mather T, Schulze T, Stafford K, Fish D. Effects of Tick Control by Acaricide Self-Treatment of White-Tailed Deer on Host-Seeking Tick Infection Prevalence and Entomologic Risk for Ixodes scapularis-Borne Pathogens. Vector-Borne And Zoonotic Diseases 2009, 9: 431-438. PMID: 19650738, DOI: 10.1089/vbz.2008.0155.Peer-Reviewed Original ResearchConceptsEntomologic riskInfection prevalenceB. burgdorferiPrevalence of infectionFever group spirochetesBacterial coinfectionSelf treatmentTick infection prevalenceLyme diseaseBorrelia miyamotoiB. miyamotoiBacterial agentsPrevalenceBorrelia burgdorferiAnaplasma phagocytophilumA. phagocytophilumAdultsRiskBurgdorferiInfectionDiseaseHost-seeking ticksProportion of ticksAdult ticksTick control
2007
Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle
Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle. Infection And Immunity 2007, 75: 4237-4244. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/iai.00632-07.Peer-Reviewed Original ResearchConceptsB. burgdorferiSecond blood mealMurine modelSpirochete transmissionB. burgdorferi persistenceLyme borreliosisMiceB. burgdorferi strainsProtein DI. scapularisTick gutBlood mealBurgdorferi strainsSpirochete life cycleBurgdorferiGut extractsIxodes scapularisB. burgdorferi infectivityThreefold decreaseHost-specific signalsScapularisTicksBorreliosis
2004
Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic
Bunikis J, Tsao J, Luke C, Luna M, Fish D, Barbour A. Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic. The Journal Of Infectious Diseases 2004, 189: 1515-1523. PMID: 15073690, DOI: 10.1086/382594.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialBacterial Outer Membrane ProteinsBlotting, WesternBorrelia burgdorferiConnecticutDisease ReservoirsDNA, BacterialEndemic DiseasesFemaleImmunoenzyme TechniquesIncidenceIxodesLongitudinal StudiesLyme DiseasePeromyscusPolymerase Chain ReactionRodent DiseasesSeasonsSeroepidemiologic StudiesConceptsPeromyscus leucopus miceLeucopus miceTransmission seasonBorrelia burgdorferi infectionPolymerase chain reactionSurface protein CBurgdorferi infectionBlood samplesMice ageEnzyme immunoassayLyme borreliosisMiceSerum samplesProtein CDynamics of infectionBorrelia burgdorferiB. burgdorferiChain reactionLongitudinal studyEnzootic siteInfectionAntibodiesEntire populationBurgdorferiIxodes scapularis
2001
Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host
Levin M, Fish D. Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host. Vector-Borne And Zoonotic Diseases 2001, 1: 139-148. PMID: 12653144, DOI: 10.1089/153036601316977741.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisE. phagocytophilaB. burgdorferiGranulocytic ehrlichiosisLyme diseaseB. burgdorferi challengeGroups of miceB. burgdorferi-infected miceBurgdorferi-infected miceXenodiagnostic larvaeI. scapularis larvaeUninfected miceNatural reservoir hostsControl miceInfectious challengePrimary infectionXenodiagnostic ticksControl groupMiceInfectionMixed infectionsI. scapularis nymphsBurgdorferiWeekly intervalsSecond agentEffect of Tick Removal on Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs
Vignes F, Piesman J, Heffernan R, Schulze T, Stafford K, Fish D. Effect of Tick Removal on Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs. The Journal Of Infectious Diseases 2001, 183: 773-778. PMID: 11181154, DOI: 10.1086/318818.Peer-Reviewed Original ResearchConceptsEhrlichia phagocytophilaBorrelia burgdorferiLyme disease endemic areaHuman granulocytic ehrlichiosisDisease-endemic areasScapularis nymphsPolymerase chain reaction analysisSerologic testingField strainsChain reaction analysisSpirochete Borrelia burgdorferiIxodes scapularis nymphsTick removalProbability of infectionHuman infectionsE. phagocytophilaGranulocytic ehrlichiosisInfectionI. scapularis nymphsB. burgdorferiBurgdorferiMiceLyme disease spirochete Borrelia burgdorferiNymphal Ixodes scapularisFed ticks
1999
Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis - Volume 5, Number 2—April 1999 - Emerging Infectious Diseases journal - CDC
Levin M, Vignes F, Fish D. Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis - Volume 5, Number 2—April 1999 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1999, 5: 204-208. PMID: 10221871, PMCID: PMC2640706, DOI: 10.3201/eid0502.990203.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAgent of HGEB. burgdorferi infectionBurgdorferi infectionInfectious Diseases journal - CDCBorrelia burgdorferiWhite-footed miceIxodes scapularis ticksWild white-footed miceDifferent prevalenceGranulocytic ehrlichiosisPrevalenceMiceScapularis ticksInfectionHost-seeking ticksNatural cycleBurgdorferiTicksAgentsEhrlichiosis
1997
Feeding Density Influences Acquisition of Borrelia burgdorferi in Larval Ixodes scapularis (Acari: Ixodidae)
Levin M, Papero M, Fish D. Feeding Density Influences Acquisition of Borrelia burgdorferi in Larval Ixodes scapularis (Acari: Ixodidae). Journal Of Medical Entomology 1997, 34: 569-572. PMID: 9379464, DOI: 10.1093/jmedent/34.5.569.Peer-Reviewed Original ResearchConceptsPrevalence of infectionBorrelia burgdorferi transmissionConsecutive weeksLarval Ixodes scapularisSpirochete prevalenceBorrelia burgdorferiB. burgdorferiLarval I. scapularisInfluences acquisitionPrevalenceBurgdorferiIxodes scapularisWhite-footed mouseIxodes scapularis SayI. scapularisEfficiency of acquisitionI. scapularis populationsInfectionMiceOspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks
de Silva AM, Fish D, Burkot TR, Zhang Y, Fikrig E. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infection And Immunity 1997, 65: 3146-3150. PMID: 9234767, PMCID: PMC175444, DOI: 10.1128/iai.65.8.3146-3150.1997.Peer-Reviewed Original ResearchConceptsOspA antibodiesB. burgdorferiPassive antibody transferB. burgdorferi infectionIxodes ticksSurface protein ABurgdorferi-infected miceB. burgdorferi-infected miceLarval infection ratesOuter surface protein AAntibody transferAntibody responseBurgdorferi infectionInfection rateInfected ticksMiceInhibitory effectAntibodiesLarval infectionBorrelia burgdorferiBurgdorferiInfectionLarval ticksReservoir competenceSpirochetesInhibition of efficient polymerase chain reaction amplification of Borrelia burgdorferi DNA in blood-fed ticks.
Schwartz I, Varde S, Nadelman R, Wormser G, Fish D. Inhibition of efficient polymerase chain reaction amplification of Borrelia burgdorferi DNA in blood-fed ticks. American Journal Of Tropical Medicine And Hygiene 1997, 56: 339-42. PMID: 9129540, DOI: 10.4269/ajtmh.1997.56.339.Peer-Reviewed Original ResearchConceptsB. burgdorferi DNABorrelia burgdorferi DNAB. burgdorferiInfection rateB. burgdorferi infectionPolymerase chain reaction analysisUtility of PCRInhibitory substancesBurgdorferi infectionChain reaction analysisPCR analysisPositive PCR signalUnfed ticksPolymerase chain reaction amplificationBlood-feeding ticksChain reaction amplificationTick lysatesEngorged ticksPCR amplificationBlood mealSuch inhibitionBurgdorferiEquivalent cohortsReaction amplificationInhibitors
1995
Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21
Coughlin R, Fish D, Mather T, Ma J, Pavia C, Bulger P. Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21. The Journal Of Infectious Diseases 1995, 171: 1049-1052. PMID: 7706788, DOI: 10.1093/infdis/171.4.1049.Peer-Reviewed Original ResearchConceptsProtection of dogsAdjuvant QS21Vaccinated dogsControl dogsLyme diseaseIxodes scapularisOuter surface protein ABorrelia burgdorferi infectionB. burgdorferiSurface protein ADogsBurgdorferi infectionVaccineScapularisQS21InfectionDiseaseProtectionXenodiagnosisBurgdorferiProtein AFeverSymptomsLimp
1993
The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area.
Falco R, Smith H, Fish D, Mojica B, Bellinger M, Harris H, Hechemy K. The distribution of canine exposure to Borrelia burgdorferi in a Lyme-Disease endemic area. American Journal Of Public Health 1993, 83: 1305-1310. PMID: 8363007, PMCID: PMC1694954, DOI: 10.2105/ajph.83.9.1305.Peer-Reviewed Original ResearchConceptsCanine exposureEnzyme-linked immunosorbentLyme diseaseBorrelia burgdorferiLyme disease endemic areaIntensity of exposureHuman Lyme diseaseDistribution of exposureSeroprevalence ratesBlood samplesEndemic areasEquivocal samplesResident dogsWestchester CountyDiseaseMean numberCausative agentSignificant differencesExposureImmunosorbentDogsHuman riskBurgdorferiSimilar patternClose association
1988
Serologic analyses of Peromyscus leucopus, a rodent reservoir for Borrelia burgdorferi, in northeastern United States
Magnarelli L, Anderson J, Hyland K, Fish D, Mcaninch J. Serologic analyses of Peromyscus leucopus, a rodent reservoir for Borrelia burgdorferi, in northeastern United States. Journal Of Clinical Microbiology 1988, 26: 1138-1141. PMID: 3384925, PMCID: PMC266549, DOI: 10.1128/jcm.26.6.1138-1141.1988.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayLyme diseaseBorrelia burgdorferiB. burgdorferiIndirect fluorescent antibody testIndirect fluorescent antibody methodFluorescent antibody testSpirochete infectionSerologic analysisSerum specimensFluorescent antibody methodImmunosorbent assayDiseaseRodent reservoirsCausative agentAntibodiesBurgdorferiMicePeromyscus leucopusControl programsElevated amountsThreefold differenceInfectionPrevalence
1987
Choroid Plexitis in White-tailed Deer (Odocoileus virginianus) in Southern New York State
Levine S, Fish D, Magnarelli L, Anderson J. Choroid Plexitis in White-tailed Deer (Odocoileus virginianus) in Southern New York State. Veterinary Pathology 1987, 24: 207-210. PMID: 3603961, DOI: 10.1177/030098588702400302.Peer-Reviewed Original ResearchConceptsChoroid plexitisHistologic evidenceSerologic evidenceNerve rootsSouthern New York StatePast infectionSpinal cordDural lesionsPneumostrongylus tenuisPlexitisLyme diseaseNew York StateSkeletal muscleInfectionBorrelia burgdorferiB. burgdorferiCausative agentIxodes damminiMuscle tissueBurgdorferiTick vectorEvidenceNerveCausal relationshipCord
1986
SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA
Magnarelli L, Anderson J, Apperson C, Fish D, Johnson R, Chappell W. SPIROCHETES IN TICKS AND ANTIBODIES TO BORRELIA BURGDORFERI IN WHITE-TAILED DEER FROM CONNECTICUT, NEW YORK STATE, AND NORTH CAROLINA. Journal Of Wildlife Diseases 1986, 22: 178-188. PMID: 3520030, DOI: 10.7589/0090-3558-22.2.178.Peer-Reviewed Original ResearchConceptsB. burgdorferiIndirect immunofluorescence testIxodes damminiDirect fluorescent antibodyTick-infested areasSerologic evidenceLeptospira infectionImmunofluorescence testEtiologic agentLyme diseaseInfected ticksSerum samplesAntibodiesI. scapularisFluorescent antibodyRabbit antibodiesI. dammini nymphsBurgdorferiAdultsSpirochetesAmericanum adultsAmblyomma americanum adultsWhite-tailed deerIxodid ticksTicks