Enhanced Stimulation of Anti‐Ovarian Cancer CD8+ T Cells by Dendritic Cells Loaded with Nanoparticle Encapsulated Tumor Antigen
Hanlon DJ, Aldo PB, Devine L, Alvero AB, Engberg AK, Edelson R, Mor G. Enhanced Stimulation of Anti‐Ovarian Cancer CD8+ T Cells by Dendritic Cells Loaded with Nanoparticle Encapsulated Tumor Antigen. American Journal Of Reproductive Immunology 2011, 65: 597-609. PMID: 21241402, PMCID: PMC3082607, DOI: 10.1111/j.1600-0897.2010.00968.x.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationAntigens, DifferentiationAntigens, NeoplasmCarcinomaCD8-Positive T-LymphocytesCells, CulturedCytokinesDendritic CellsFemaleHumansImmunotherapy, AdoptiveLactic AcidLymphocyte ActivationNanoparticlesOvarian NeoplasmsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerConceptsTumor-associated antigensT cell responsesT cellsDendritic cellsCytokine productionTumor antigensAnti-tumor T cell responsesCell surface co-stimulatory moleculesCD8 T cell responsesSurface co-stimulatory moleculesAnti-tumor immune responseAntigen-loaded DCsTumor lysate antigensCD8 T cellsCo-stimulatory moleculesT cell expressionHuman DCsActivation markersTumor lysateImmune responseLysate antigenBlood monocytesClinical testingEnhanced stimulationAntigen