Polymer Nanoparticles for Immunotherapy from Encapsulated Tumor-Associated Antigens and Whole Tumor Cells
Solbrig CM, Saucier-Sawyer JK, Cody V, Saltzman WM, Hanlon DJ. Polymer Nanoparticles for Immunotherapy from Encapsulated Tumor-Associated Antigens and Whole Tumor Cells. Molecular Pharmaceutics 2007, 4: 47-57. PMID: 17217312, DOI: 10.1021/mp060107e.Peer-Reviewed Original ResearchConceptsPolymer nanoparticlesMixture of proteinsMolecular weight polymersRate of nanoparticlesProtein loadingEfficiency of encapsulationWeight polymersDissolved nanoparticlesNanoparticle formulationDifferent particle loadingsRelease propertiesNanoparticlesPreparation methodEncapsulation efficiencyComplex mixturesMolecular weightSDS-acrylamide gel electrophoresisSolvent extractionProtein assaysAgEncapsulationParticle loadingMixtureSpectrum of proteinsPromising approach