2003
Dietary carotenoids and risk of coronary artery disease in women 1 , 2 , 3
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Manson JE, Willett WC. Dietary carotenoids and risk of coronary artery disease in women 1 , 2 , 3. American Journal Of Clinical Nutrition 2003, 77: 1390-1399. PMID: 12791615, DOI: 10.1093/ajcn/77.6.1390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntioxidantsBeta CaroteneCarotenoidsCoronary DiseaseDietDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansMiddle AgedProspective StudiesRiskConceptsRisk of CADCoronary artery diseaseArtery diseaseHigh intakePrevention of CADIncident coronary artery diseaseSemiquantitative food frequency questionnaireCAD risk factorsBeta-carotene supplementationFood frequency questionnaireCurrent smoking statusDietary carotenoidsSignificant inverse associationLutein/zeaxanthinHigh blood concentrationsConsumption of carotenoidsCAD riskSmoking statusIncident casesHighest quintileLowest quintileInverse associationRisk factorsDietary intakeBlood concentrations
2000
Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women.
Holmes M, Spiegelman D, Willett W, Manson J, Hunter D, Barbieri R, Colditz G, Hankinson S. Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. Journal Of Clinical Oncology 2000, 18: 3668-76. PMID: 11054440, DOI: 10.1200/jco.2000.18.21.3668.Peer-Reviewed Original ResearchConceptsDietary fat intakeFat intakePostmenopausal womenInverse associationHormone levelsSex steroid hormone levelsHealthy postmenopausal womenTotal fat intakeFood frequency questionnaireEndogenous estrogen levelsBreast cancer riskOmega-3 fatsSex steroid hormonesCross-sectional associationsSteroid hormone levelsPercentage of energyEstradiol levelsEstrogen levelsPlasma sex steroidsPlasma levelsSex steroidsCancer riskProtein intakeEnergy intakeSteroid hormones
1999
Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1
Walsh B, Spiegelman D, Morrissey M, Sacks F. Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 985-989. PMID: 10084583, DOI: 10.1210/jcem.84.3.5571.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodEstradiolFemaleHumansLipoproteinsLipoproteins, HDLMiddle AgedOsmolar ConcentrationPostmenopause
1989
Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients.
Spiegelman D, Maurer LH, Ware JH, Perry MC, Chahinian AP, Comis R, Eaton W, Zimmer B, Green M. Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients. Journal Of Clinical Oncology 1989, 7: 344-54. PMID: 2537384, DOI: 10.1200/jco.1989.7.3.344.Peer-Reviewed Original ResearchConceptsLong-term survivalPerformance statusOverall survivalPrognostic factorsED patientsMetastatic sitesLung cancerExtensive small cell lung cancerResponse rateSmall cell lung cancerFailure-free survivalOverall objective responseLead-time biasLeukemia Group BPretreatment prognostic factorsSmall cell carcinomaLung cancer stagingImproved response ratesPercentage of womenObjective responseSupraclavicular lymphPatient populationLD patientsCancer stagingFemale gender