2024
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
Shrestha A, Tamrakar D, Ghinanju B, Shrestha D, Khadka P, Adhikari B, Shrestha J, Waiwa S, Pyakurel P, Bhandari N, Karmacharya B, Shrestha A, Shrestha R, Bhatta R, Malik V, Mattei J, Spiegelman D. Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace. PLOS ONE 2024, 19: e0301826. PMID: 38656951, PMCID: PMC11042715, DOI: 10.1371/journal.pone.0301826.Peer-Reviewed Original ResearchConceptsConsumption of whole grainsHealthy foodPre-post intervention studyWhole grainsMedian consumptionCardiovascular risk factor profileRisk factor profileBlood pressureWorksite settingWorksite interventionsUnhealthy foodsHealth programsMeasured blood pressurePre-hypertensionCardiometabolic riskDiastolic blood pressureIntervention studiesFactors dietPaired-t testFactor profileFasting glucose levelsDhulikhel HospitalHospital premisesEmployee healthHospital employeesCausal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure
Tang W, Spiegelman D, Liao X, Wang M. Causal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure. Epidemiology 2024, 35: 320-328. PMID: 38630507, DOI: 10.1097/ede.0000000000001706.Peer-Reviewed Original ResearchConceptsMismeasured exposureOutcome modelRegression calibrationMeasurement error modelSelection of covariatesNonparametric settingEffect modificationCovariate adjustmentFiber intakeMeasurement errorCardiovascular diseaseEffects of fiber intakeStudy datasetOutcomesCovariatesComprehensive guidanceError modelRegressionHealthEfficiency lossErrorRosnerWillettExposureAdjustment
2022
Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy. Journal Of The American College Of Cardiology 2022, 79: 1901-1913. PMID: 35550687, PMCID: PMC9176211, DOI: 10.1016/j.jacc.2022.03.335.Peer-Reviewed Original ResearchConceptsCVD risk factorsRates of CVDHealth Study IIRisk of CVDBody mass indexGestational hypertensionType 2 diabetesRisk factorsChronic hypertensionHypertensive disordersMass indexNurses' Health Study IIPrepregnancy body mass indexHistory of HDPCardiovascular risk factorsOverweight/obesityProportional hazards modelIncident CVDCVD preventionNormotensive pregnanciesFirst pregnancyPotential confoundersParental historyHypertensionHazards model
2021
Health system gaps in cardiovascular disease prevention and management in Nepal
Shrestha A, Maharjan R, Karmacharya BM, Bajracharya S, Jha N, Shrestha S, Aryal A, Baral PP, Bhatt RD, Bhattarai S, Bista D, Citrin D, Dhimal M, Fitzpatrick AL, Jha AK, Karmacharya RM, Mali S, Neupane T, Oli N, Pandit R, Parajuli SB, Pradhan PMS, Prajapati D, Pyakurel M, Pyakurel P, Rai BK, Sapkota BP, Sapkota S, Shrestha A, Shrestha AP, Shrestha R, Sharma GN, Sharma S, Spiegelman D, Suwal PS, Thapa B, Vaidya A, Xu D, Yan LL, Koju R. Health system gaps in cardiovascular disease prevention and management in Nepal. BMC Health Services Research 2021, 21: 655. PMID: 34225714, PMCID: PMC8258928, DOI: 10.1186/s12913-021-06681-0.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesDelivery of Health CareGovernment ProgramsHumansMedical AssistanceNepalConceptsHealth systemCardiovascular disease preventionCause of deathHealth system gapsQuality of careResource-limited settingsNational health policyHealth system performanceBackgroundCardiovascular diseaseCVD preventionCVD careCVD servicesHealth outcomesDisease preventionHealth policyHealth insuranceHealth spendingCarePreventionKey informant interviewsTask ForceSystem gapsInformant interviewsService deliverySafety
2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarctionEstimation in the Cox survival regression model with covariate measurement error and a changepoint
Agami S, Zucker DM, Spiegelman D. Estimation in the Cox survival regression model with covariate measurement error and a changepoint. Biometrical Journal 2020, 62: 1139-1163. PMID: 32003495, DOI: 10.1002/bimj.201800085.Peer-Reviewed Original ResearchMeSH KeywordsBiasCalibrationCardiovascular DiseasesComputer SimulationHumansLongitudinal StudiesMyocardial InfarctionProportional Hazards ModelsSurvival AnalysisConceptsSystolic blood pressure levelsChronic air pollution exposureCox survival regression modelFatal myocardial infarctionBlood pressure levelsCardiovascular disease deathsCox regression modelAir pollution exposureRegression modelsDisease deathsMyocardial infarctionRelative riskStandard Cox modelSurvival regression modelsCox modelPollution exposureSurvival endpointsCovariates of interest
2019
Stakeholder Engagement in Planning the Design of a National Needs Assessment for Cardiovascular Disease Prevention and Management in Nepal
Archana S, Karmacharya BM, Rashmi M, Abhinav V, Meghnath D, Natalia O, Rajeev S, Prajjwal P, Annette F, David C, Swornim B, Roman XD, Donna S, Rajendra K. Stakeholder Engagement in Planning the Design of a National Needs Assessment for Cardiovascular Disease Prevention and Management in Nepal. Global Heart 2019, 14: 181-189. PMID: 31324373, PMCID: PMC7003959, DOI: 10.1016/j.gheart.2019.05.002.Peer-Reviewed Original Research
2018
Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial
Mohan V, Gayathri R, Jaacks LM, Lakshmipriya N, Anjana RM, Spiegelman D, Jeevan RG, Balasubramaniam KK, Shobana S, Jayanthan M, Gopinath V, Divya S, Kavitha V, Vijayalakshmi P, Bai R M, Unnikrishnan R, Sudha V, Krishnaswamy K, Salas-Salvadó J, Willett WC. Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial. Journal Of Nutrition 2018, 148: 63-69. PMID: 29378038, DOI: 10.1093/jn/nxx001.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureNut consumptionBody weightAsian IndiansHDL cholesterolDiabetic dietNut supplementationSelf-reported dietary intakeStandard diabetic dietClinical Trials RegistryHDL cholesterol concentrationsPlasma HDL cholesterolType 2 diabetesCashew nut consumptionBlood lipidsControlled TrialsTrials RegistryGlycemic variablesLipid variablesDietary intakeIntervention groupLipid profileCardiovascular diseaseRobust variance estimation
2011
Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania.
Njelekela MA, Liu E, Mpembeni R, Muhihi A, Mligiliche N, Spiegelman D, Finkelstein JL, Fawzi WW, Willett WC, Mtabaji J. Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania. East African Journal Of Public Health 2011, 8: 216-23. PMID: 23120960.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesCross-Sectional StudiesDietExerciseFemaleHealth BehaviorHumansLife StyleLipidsLogistic ModelsMaleMetabolic SyndromeMiddle AgedObesityResidence CharacteristicsRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesTanzaniaUrban HealthUrbanizationWaist CircumferenceConceptsCardiometabolic risk factorsPoorer lipid profileHigher socioeconomic statusRisk factorsLipid profileSocioeconomic statusUrban residenceCardio-metabolic risk factorsWorld Health Organization criteriaHigher total cholesterolHigh waist circumferenceRisk of obesityHealth screening strategiesMiddle-aged adultsMetabolic syndromeTotal cholesterolWaist circumferenceLDL cholesterolHigher BMIPrimary preventionLower triglyceridesOrganization criteriaDietary factorsCardiovascular diseaseGlucose levels
2004
Fruit and Vegetable Intake and Risk of Major Chronic Disease
Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, Colditz GA, Rosner B, Spiegelman D, Willett WC. Fruit and Vegetable Intake and Risk of Major Chronic Disease. Journal Of The National Cancer Institute 2004, 96: 1577-1584. PMID: 15523086, DOI: 10.1093/jnci/djh296.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceCardiovascular DiseasesCause of DeathChronic DiseaseConfidence IntervalsConfounding Factors, EpidemiologicDiet SurveysFeeding BehaviorFemaleFollow-Up StudiesFruitHealth PersonnelHumansIncidenceMaleMiddle AgedNeoplasmsProportional Hazards ModelsProspective StudiesResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesUnited StatesVegetablesConceptsMajor chronic diseasesVegetable intakeCardiovascular diseaseChronic diseasesRelative riskHealth StudyVegetable consumptionGreen leafy vegetable intakeSemiquantitative food frequency questionnaireCox proportional hazards analysisOverall cancer incidenceTotal fruitNurses' Health StudyFood frequency questionnaireProportional hazards analysisStrong inverse associationProspective cohortGreen leafy vegetablesHighest quintileInverse associationCancer incidenceFood groupsHealth professionalsOverall healthDietary informationSexual Orientation, Health Risk Factors, and Physical Functioning in the Nurses' Health Study II
Case P, Austin SB, Hunter DJ, Manson JE, Malspeis S, Willett WC, Spiegelman D. Sexual Orientation, Health Risk Factors, and Physical Functioning in the Nurses' Health Study II. Journal Of Women's Health 2004, 13: 1033-1047. PMID: 15665660, DOI: 10.1089/jwh.2004.13.1033.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingBisexualityBody Mass IndexBreast NeoplasmsCardiovascular DiseasesCross-Sectional StudiesDepressionFemaleHealth BehaviorHealth StatusHomosexuality, FemaleHumansLinear ModelsMental HealthMiddle AgedMultivariate AnalysisNurse CliniciansPrevalenceProspective StudiesRisk FactorsSmokingTime FactorsUnited StatesConceptsNurses' Health Study IIHealth Study IIBody mass indexRisk factorsHealth risk factorsHigh prevalenceRegion of residenceOverall cohortBreast cancerHealth statusHigher daily alcohol intakeCardiovascular disease risk factorsBreast cancer risk factorsHigher body mass indexStudy IIMultivariate prevalence ratiosDaily alcohol intakeDisease risk factorsUse of antidepressantsCancer risk factorsHealth-related functioningImportant risk factorMental health statusPoor mental healthBisexual womenInference for the Proportional Hazards Model with Misclassified Discrete‐Valued Covariates
Zucker DM, Spiegelman D. Inference for the Proportional Hazards Model with Misclassified Discrete‐Valued Covariates. Biometrics 2004, 60: 324-334. PMID: 15180657, DOI: 10.1111/j.0006-341x.2004.00176.x.Peer-Reviewed Original Research
2003
Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women
Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC. Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women. American Journal Of Epidemiology 2003, 158: 760-771. PMID: 14561666, DOI: 10.1093/aje/kwg221.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesFolate intakeChronic diseasesCardiovascular diseaseLower total folate intakeJoint associationsMultivariate relative riskNonfatal cardiovascular diseaseTotal folate intakeHigh folate intakeAdequate folate intakeAge 60 yearsLow folate intakePrimary preventionNontraumatic deathsRelative riskHigh riskPrevious historyDietary dataHeavy drinkersNew casesYoung womenDiseaseHeavy drinkingIntake
2002
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance 1 , 2 , 3
McCullough ML, Feskanich D, Stampfer MJ, Giovannucci EL, Rimm EB, Hu FB, Spiegelman D, Hunter DJ, Colditz GA, Willett WC. Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1261-1271. PMID: 12450892, DOI: 10.1093/ajcn/76.6.1261.Peer-Reviewed Original ResearchConceptsAlternate Healthy Eating IndexRecommended Food ScoreHealthy Eating IndexChronic disease riskMajor chronic diseasesMajor chronic disease riskCardiovascular diseaseChronic diseasesDisease riskDietary guidelinesHealth StudyDiet qualityChronic disease risk reductionAgriculture Healthy Eating IndexHigher AHEI scoreNurses' Health StudyDisease risk reductionStrong inverse associationDietary questionnaireAHEI scoreLowest quintileNontraumatic deathsFood ScoreInverse associationHealth professionals
2001
Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
Chu N, Spiegelman D, Hotamisligil G, Rifai N, Stampfer M, Rimm E. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 2001, 157: 495-503. PMID: 11472752, DOI: 10.1016/s0021-9150(00)00755-3.Peer-Reviewed Original ResearchConceptsCVD risk factorsRisk factorsPlasma insulinCVD riskHDL cholesterolInsulin levelsPlasma leptinAntigen levelsSoluble TNF receptor levelsCardiovascular disease risk factorsTissue plasminogen activator antigen levelsT-PA antigen levelsMetabolic cardiovascular syndromeHealth Professionals FollowIndependent risk factorDisease risk factorsEffect of obesitySoluble TNF receptorsTNF receptor levelsCardiovascular disease morbidityBody mass indexLevels of insulinProfessionals FollowLeptin levelsMass indexAssociation between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 1 , 2 , 3
Fung T, Rimm E, Spiegelman D, Rifai N, Tofler G, Willett W, Hu F. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 61-67. PMID: 11124751, DOI: 10.1093/ajcn/73.1.61.Peer-Reviewed Original ResearchConceptsMajor dietary patternsFood frequency questionnaireBiomarkers of obesityDietary patternsHomocysteine concentrationsHigh intakePattern scoresHigh-fat dairy productsHealth Professionals FollowOverall dietary patternsCardiovascular disease riskBody mass indexPlasma folate concentrationsPrudent patternProfessionals FollowCVD riskDevelopment of diseaseSmoking statusAlcohol intakeMass indexPotential confoundersObesity riskPlasma biomarkersPlasma folateRisk factors
2000
Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk
Fung TT, Hu FB, Yu J, Chu NF, Spiegelman D, Tofler GH, Willett WC, Rimm EB. Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk. American Journal Of Epidemiology 2000, 152: 1171-1178. PMID: 11130623, DOI: 10.1093/aje/152.12.1171.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityDensity lipoprotein cholesterolPhysical activityCVD riskLipoprotein cholesterolHDL cholesterolCardiovascular diseaseTelevision watchingLong-term leisure-time physical activityHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolLong-term physical activityMale health professionalsBiomarkers of obesityCardiovascular disease riskBlood lipidsThrombogenic factorsLeptin levelsInsulin sensitivityC-peptideApolipoprotein A1Vigorous activityLinear regression analysisBiochemical markersHealth professionalsAdherence to the Dietary Guidelines for Americans and risk of major chronic disease in men 1 , 2 , 3 , 4 , 5
McCullough M, Feskanich D, Rimm E, Giovannucci E, Ascherio A, Variyam J, Spiegelman D, Stampfer M, Willett W. Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men 1 , 2 , 3 , 4 , 5. American Journal Of Clinical Nutrition 2000, 72: 1223-1231. PMID: 11063453, DOI: 10.1093/ajcn/72.5.1223.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesChronic diseasesFood Guide PyramidDietary guidelinesCardiovascular diseaseLower riskIncident major cardiovascular diseaseUS male health professionalsMale health professionalsFood frequency questionnaireChronic disease outcomesHigher HEI scoresMajor cardiovascular diseasesLower cancer riskHEI scoresHeart diseaseRisk factorsDietary patternsDisease outcomeFood intakeCancer riskHealth professionalsMEN 1Detailed questionnaireDisease
1999
A Prospective Study of Egg Consumption and Risk of Cardiovascular Disease in Men and Women
Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH, Willett WC. A Prospective Study of Egg Consumption and Risk of Cardiovascular Disease in Men and Women. JAMA 1999, 281: 1387-1394. PMID: 10217054, DOI: 10.1001/jama.281.15.1387.Peer-Reviewed Original ResearchConceptsRisk of CHDCoronary heart diseaseHigher egg consumptionIncident casesEgg consumptionRelative riskCardiovascular diseaseHealth StudyFatal coronary heart diseaseStudy outsetIncident nonfatal myocardial infarctionCHD risk factorsHealth Professionals FollowNonfatal myocardial infarctionNurses' Health StudyProspective cohort studyFood frequency questionnaireCategories of intakeBlood cholesterol levelsDaily egg consumptionOverall significant associationProfessionals FollowCohort studyDiabetic subjectsProspective studyDistribution of and Factors Associated With Serum Homocysteine Levels in Children: Child and Adolescent Trial for Cardiovascular Health
Osganian SK, Stampfer MJ, Spiegelman D, Rimm E, Cutler JA, Feldman HA, Montgomery DH, Webber LS, Lytle LA, Bausserman L, Nader PR. Distribution of and Factors Associated With Serum Homocysteine Levels in Children: Child and Adolescent Trial for Cardiovascular Health. JAMA 1999, 281: 1189-1196. PMID: 10199428, DOI: 10.1001/jama.281.13.1189.Peer-Reviewed Original ResearchConceptsSerum folic acidSystolic blood pressureHomocysteine levelsHomocysteine concentrationsCardiovascular diseaseSerum homocysteineAdolescent TrialBlood pressureSerum levelsFolic acidCardiovascular healthSerum total homocysteine concentrationsVitamin B12Mean homocysteine concentrationFuture cardiovascular diseaseVitamin B12 levelsSerum homocysteine concentrationsSchool-based cohortSerum homocysteine levelsTotal homocysteine concentrationsSerum lipid levelsBody mass indexCross-sectional analysisNonusers of multivitaminsB12 levels