2020
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
McGee EE, Kim CH, Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research 2020, 22: 78. PMID: 32698885, PMCID: PMC7374956, DOI: 10.1186/s13058-020-01316-4.Peer-Reviewed Original ResearchConceptsBreast cancer riskImmuno-inflammatory markersErythrocyte membrane fatty acidsCase-control studyTumor tissue expressionFatty acid synthaseCancer riskTrans fatty acidsExpression subtypesOdds ratioSpecific fatty acidsLogistic regressionHealth Study IITumor tissue blocksMembrane fatty acidsFatty acidsUnconditional logistic regressionConfidence intervalsTissue expressionT cell functionPolytomous logistic regressionAcid synthaseTumor CD4Potential confoundersTumor expression
2005
Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India
Rastogi T, Jha P, Reddy KS, Prabhakaran D, Spiegelman D, Stampfer MJ, Willett WC, Ascherio A. Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India. Tobacco Control 2005, 14: 356. PMID: 16183987, PMCID: PMC1748103, DOI: 10.1136/tc.2005.011965.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesHumansIndiaMaleMiddle AgedMyocardial InfarctionRisk AssessmentSmokingTobacco, SmokelessUrban HealthPredictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scoreIncreasing Risk of 5% or Greater Unintentional Weight Loss in a Cohort of HIV-Infected Patients, 1995 to 2003
Tang AM, Jacobson DL, Spiegelman D, Knox TA, Wanke C. Increasing Risk of 5% or Greater Unintentional Weight Loss in a Cohort of HIV-Infected Patients, 1995 to 2003. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 70-76. PMID: 16123685, DOI: 10.1097/01.qai.0000159627.54149.2e.Peer-Reviewed Original ResearchConceptsCohort of HIVUnintentional weight lossWeight lossAntiretroviral therapyBody compositionLow CD4 cell countsHigher HIV viral loadHigher body mass indexCare of HIVHealthy Living cohortActive antiretroviral therapyCD4 cell countCombination antiretroviral therapyHIV viral loadBody mass indexRisk of deathPresence of diarrheaFederal poverty levelLiving cohortHIV infectionMass indexMost AIDSOpportunistic infectionsViral loadPatient populationTemporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis
Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A. Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis. JAMA 2005, 293: 2496-2500. PMID: 15914750, DOI: 10.1001/jama.293.20.2496.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr virusMultiple sclerosisAntibody titersEBNA complexRelative riskDevelopment of MSEBV viral capsid antigenEpstein-Barr virus (EBV) antibody titersRisk of MSOnset of MSOnset of symptomsVirus antibody titersSerum antibody titersCase-control studyDefense Serum RepositoryAge 25 yearsBlood sample collectionUS military personnelTemporal relationshipCase-control setsRace/ethnicityAge-dependent relationshipEBV infectionCytomegalovirus antibodiesPlasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Campos H, Spiegelman D, Zhang S, Colditz GA, Willett WC, Hunter DJ. Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer. American Journal Of Epidemiology 2005, 161: 153-160. PMID: 15632265, DOI: 10.1093/aje/kwi030.Peer-Reviewed Original ResearchConceptsLutein/zeaxanthinBreast cancerHealth StudyPlasma carotenoidsNurses' Health StudyBreast cancer riskCase-control studyBreast cancer etiologyNodal metastasisHighest quintileInvasive cancerLowest quintileBlood drawInverse associationCancer riskAlpha-tocopherolCancerCancer etiologyGamma-tocopherolWomenRetinolQuintileRiskRole of carotenoidsAssociation
2004
Physical activity and risk of coronary heart disease in India
Rastogi T, Vaz M, Spiegelman D, Reddy KS, Bharathi A, Stampfer MJ, Willett WC, Ascherio A. Physical activity and risk of coronary heart disease in India. International Journal Of Epidemiology 2004, 33: 759-767. PMID: 15044412, DOI: 10.1093/ije/dyh042.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesCoronary DiseaseDeveloping CountriesEmploymentEnergy MetabolismExerciseFemaleHumansIndiaMaleMiddle AgedRiskConceptsLeisure-time exerciseCHD riskRisk factorsPhysical activityPhysical exerciseSedentary activitiesHospital-based case-control studyCoronary heart disease riskDisease riskHeart disease riskCoronary heart diseaseAcute myocardial infarctionRisk of CHDSex-adjusted analysesCase-control studyConditional logistic regressionPhysical inactivity levelsMultivariate adjustmentBrisk walkingMyocardial infarctionHeart diseaseRelative riskSedentary lifestyleElevated riskMultivariate analysisCommon ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study
Tamimi RM, Hankinson SE, Spiegelman D, Kraft P, Colditz GA, Hunter DJ. Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study. Breast Cancer Research 2004, 6: r416. PMID: 15217510, PMCID: PMC468661, DOI: 10.1186/bcr809.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtaxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsBreast NeoplasmsCase-Control StudiesCell Cycle ProteinsCohort StudiesDNA-Binding ProteinsFemaleHaplotypesHumansMiddle AgedMutationNursesPolymorphism, Single NucleotideProtein Serine-Threonine KinasesRisk FactorsSurveys and QuestionnairesTumor Suppressor ProteinsConceptsSingle nucleotide polymorphismsATM geneDNA double-strand breaksNucleotide polymorphismsDouble-strand breaksEntire genomic sequenceTumor suppressor geneCommon variationCell cycle arrestHaplotype diversityUnique haplotypesGenomic sequencesAtaxia telangiectasiaSingle nucleotide polymorphism detectionSporadic breast cancer riskSuppressor geneCycle arrestGenesATM haplotypesPolymorphism detectionCommon haplotypeHaplotypesGenotype informationHaplotype analysisMutationsManganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stressDiet and risk of ischemic heart disease in India
Rastogi T, Reddy KS, Vaz M, Spiegelman D, Prabhakaran D, Willett WC, Stampfer MJ, Ascherio A. Diet and risk of ischemic heart disease in India. American Journal Of Clinical Nutrition 2004, 79: 582-592. PMID: 15051601, DOI: 10.1093/ajcn/79.4.582.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseServings/wkIHD riskLower riskHeart diseaseInverse associationHospital-based case-control studyDose-dependent inverse associationLong-term dietary intakeFood frequency questionnaireAcute myocardial infarctionCase-control studyConditional logistic regressionPredictors of riskLower relative riskAlpha-linolenic acidBasis of ageMustard oilGreen leafy vegetablesMyocardial infarctionVegetable intakeLeading causeDietary intakeCereal intakeRelative riskEarly life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles
Harlow BL, Cohen LS, Otto MW, Spiegelman D, Cramer DW. Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles. Journal Of Affective Disorders 2004, 79: 167-176. PMID: 15023491, DOI: 10.1016/s0165-0327(02)00459-7.Peer-Reviewed Original ResearchConceptsRisk of depressionMajor depressionHeavy menstrual flowMenstrual cycle characteristicsMonths of breastfeedingNumber of livebirthsYears of menstruationCurrent major depressionHistory of depressionMost risk estimatesPopulation-based sampleYears of ageWomen 36Menstrual characteristicsGynecological careStudy enrollmentDecreased riskMenstrual flowMenstrual cyclePostpartum periodCycle irregularityPsychiatric sequelaePregnancy experiencePremenstrual dysphoriaMultiple abortions
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoidsThe HRAS1 variable number of tandem repeats and risk of breast cancer.
Tamimi RM, Hankinson SE, Ding S, Gagalang V, Larson GP, Spiegelman D, Colditz GA, Krontiris TG, Hunter DJ. The HRAS1 variable number of tandem repeats and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1528-30. PMID: 14693748.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesBreast NeoplasmsCase-Control StudiesDNA, NeoplasmFemaleGenes, rasGenetic Predisposition to DiseaseGenotypeHumansLogistic ModelsMiddle AgedMinisatellite RepeatsPolymerase Chain ReactionPolymorphism, GeneticProbabilityPrognosisReference ValuesRisk AssessmentSensitivity and SpecificityTandem Repeat SequencesConceptsHealth Study cohortBreast cancer casesBreast cancerCancer casesNurses' Health Study cohortIncident breast cancer casesHRAS1 VNTRHRAS1 variable numberBreast cancer riskCase-control studyGene-dose effectRare HRAS1 allelesMenopausal statusStudy cohortCancer riskOverall associationCancerHRAS1 allelesRiskRare allelesAssociationCommon allelesAllelesVariable numberCohortHigh-fiber diet in HIV-positive men is associated with lower risk of developing fat deposition
Hendricks KM, Dong KR, Tang AM, Ding B, Spiegelman D, Woods MN, Wanke CA. High-fiber diet in HIV-positive men is associated with lower risk of developing fat deposition. American Journal Of Clinical Nutrition 2003, 78: 790-795. PMID: 14522738, DOI: 10.1093/ajcn/78.4.790.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesDietDiet RecordsDietary FiberHIV SeropositivityHumansLipodystrophyMaleRisk FactorsConceptsHIV-positive patientsFat depositionFood recordsDietary fiberHealthy Living cohortPast dietary intakeHIV-positive menCase-control studyOverall energy intakeWilcoxon rank sum testHigh-fiber dietRank sum testLiving cohortCurrent smokersDietary intakeResistance trainingLower riskEnergy intakePatientsUnhealthy behaviorsHealthy lifestyleHIVDietary componentsGreater intakeHigh-quality dietHigh 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults. Journal Of Nutrition 2003, 133: 1186-1191. PMID: 12672941, DOI: 10.1093/jn/133.4.1186.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAgedCase-Control StudiesCatchment Area, HealthCosta RicaFatty AcidsFemaleHumansMaleMiddle AgedMyocardial InfarctionRisk FactorsConceptsRisk of MICoronary heart diseaseMyocardial infarctionAdipose tissueTrans fatty acidsOdds ratioNonfatal acute myocardial infarctionTrans fatty acid intakeFirst nonfatal myocardial infarctionConditional logistic regression modelsNonfatal myocardial infarctionTrans FACosta Rican adultsAcute myocardial infarctionTotal adipose tissueAdipose tissue samplesArea of residenceIndividual trans fatty acidsLogistic regression modelsIncreased riskIncident casesAcid intakeRisk factorsAtherogenic potentialHeart diseaseMultiple Sclerosis and Epstein-Barr Virus
Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A. Multiple Sclerosis and Epstein-Barr Virus. JAMA 2003, 289: 1533-1536. PMID: 12672770, DOI: 10.1001/jama.289.12.1533.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr virusRisk of MSMultiple sclerosisRelative riskDevelopment of MSEBV viral capsid antigenOnset of MSCase-control studyDefense Serum RepositoryBlood sample collectionUS military personnelRace/ethnicityEBNA complexEBV antibodiesEBV infectionCytomegalovirus antibodiesSerum levelsCapsid antigenEarly antigenMS onsetAntibody titersIgG antibodiesPermanent disabilitySerum RepositoryAdipose Tissue α-Linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. Adipose Tissue α-Linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica. Circulation 2003, 107: 1586-1591. PMID: 12668490, DOI: 10.1161/01.cir.0000058165.81208.c6.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAlpha-Linolenic AcidBiomarkersCase-Control StudiesCosta RicaEatingFemaleHumansMaleMiddle AgedMyocardial InfarctionRisk FactorsConceptsNonfatal acute myocardial infarctionAcute myocardial infarctionAdipose tissue alpha-linolenic acidAlpha-linolenic acidMyocardial infarctionCardiovascular diseaseFirst nonfatal acute myocardial infarctionMultivariate conditional logistic regression modelPopulation-based case-control studyConditional logistic regression modelsTissue linoleic acidMI risk factorsPopulation control subjectsCase-control studyAdipose tissue samplesArea of residenceLogistic regression modelsTrans fatty acidsΑ-Linolenic AcidCase patientsFatty acidsControl subjectsLowest quintileInverse associationRisk factors
2002
Mercury and the Risk of Coronary Heart Disease in Men
Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, Stampfer MJ, Willett WC. Mercury and the Risk of Coronary Heart Disease in Men. New England Journal Of Medicine 2002, 347: 1755-1760. PMID: 12456851, DOI: 10.1056/nejmoa021437.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMale health professionalsHigh dietary intakeYears of ageCase-control designMercury levelsSmoking statusTotal mercury exposureControl subjectsLowest quintileRisk factorsDietary intakeCardiovascular diseaseRelative riskCohort membersPrevious historyToenail clippingsHealth professionalsDiseaseConsumption of fishMercury exposureMean mercury levelRiskFish consumptionThe Performance of Methods for Correcting Measurement Error in Case-Control Studies
Stürmer T, Thürigen D, Spiegelman D, Blettner M, Brenner H. The Performance of Methods for Correcting Measurement Error in Case-Control Studies. Epidemiology 2002, 13: 507-516. PMID: 12192219, DOI: 10.1097/00001648-200209000-00005.Peer-Reviewed Original ResearchIndividual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake 1 , 2 , 3
El-Sohemy A, Baylin A, Kabagambe E, Ascherio A, Spiegelman D, Campos H. Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 172-179. PMID: 12081831, DOI: 10.1093/ajcn/76.1.172.Peer-Reviewed Original ResearchConceptsAdipose tissuePartial Spearman correlation coefficientsFood frequency questionnaireBiomarkers of intakeBody mass indexTotal energy intakeVLDL-cholesterol concentrationsMajor dietary carotenoidsLong-term intakeTissue biopsy samplesIndividual carotenoid concentrationsDietary interviewSpearman correlation coefficientMass indexAdipose tissue biopsy samplesDietary intakePlasma concentrationsCarotenoid intakeBlood samplesBiopsy samplesPlasma carotenoidsTissue carotenoid concentrationsEnergy intakeIntakeDietary carotenoids