2020
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease
Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, Khulan D, Ariunzaya S, Sumiya E, Bolortuya B, Yanjmaa J, Enkhtsetseg T, Munkhzaya A, Tunsag M, Khudyakov P, Seddon JA, Marais BJ, Batbayar O, Erdenetuya G, Amarsaikhan B, Spiegelman D, Tsolmon J, Martineau AR. Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease. New England Journal Of Medicine 2020, 383: 359-368. PMID: 32706534, PMCID: PMC7476371, DOI: 10.1056/nejmoa1915176.Peer-Reviewed Original ResearchConceptsVitamin D groupAcute respiratory infectionsVitamin D supplementationPlacebo groupRespiratory infectionsTuberculosis infectionD groupVitamin DTuberculosis diseaseD supplementationAdverse eventsQFT resultsPositive QFT resultWeekly oral doseVitamin D supplementsQuantiFERON-TB GoldProportion of childrenD supplementsSecondary outcomesPrimary outcomeOral doseD levelsImmune responseLower riskInfection
2012
PREDICTORS OF INCIDENT TUBERCULOSIS IN HIV-EXPOSED CHILDREN IN TANZANIA.
Finkelstein J, Manji K, Duggan C, Hertzmark E, Mehta S, Msamanga G, Spiegelman D, Fawzi W. PREDICTORS OF INCIDENT TUBERCULOSIS IN HIV-EXPOSED CHILDREN IN TANZANIA. East African Medical Journal 2012, 89: 183-92. PMID: 26856040, PMCID: PMC10864092.Peer-Reviewed Original ResearchConceptsRisk of tuberculosisChild mid-upper arm circumferenceMid-upper arm circumferenceT-cell countsArm circumferenceReduced riskCD4 T-cell countCD8 T-cell countsLow vitamin E levelsAppropriate infant feedingDuration of breastfeedingLongitudinal cohort studyVitamin E levelsIncident tuberculosisAntenatal clinicCohort studyLymphocyte countHIV infectionTuberculosis infectionChild tuberculosisHIV statusNutritional interventionImmunological statusInfant feedingE levels
2005
Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children
Jacobson DL, Spiegelman D, Duggan C, Weinberg GA, Bechard L, Furuta L, Nicchitta J, Gorbach SL, Miller TL. Predictors of Bone Mineral Density in Human Immunodeficiency Virus‐1 Infected Children. Journal Of Pediatric Gastroenterology And Nutrition 2005, 41: 339-346. PMID: 16131991, DOI: 10.1097/01.mpg.0000174468.75219.30.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAntiretroviral Therapy, Highly ActiveBlack or African AmericanBody CompositionBody HeightBody Mass IndexBody WeightBone DensityCase-Control StudiesChildChild DevelopmentCross-Sectional StudiesFemaleHispanic or LatinoHIV InfectionsHIV-1HumansLongitudinal StudiesMalePredictive Value of TestsProspective StudiesSeverity of Illness IndexVitaminsWhite PeopleConceptsBMD Z-scoresBone mineral densityLower BMD Z-scoresMineral densityZ-scorePopulation normsMultivitamin useDietary intakePredictors of BMDTotal body bone mineral densityLower weight z-scoreBody bone mineral densityLow bone mineral densitySibling controlsBetter bone mineral densityDual-energy X-ray absorptiometry (DXA) examinationDual-energy X-ray absorptiometryLower height Z-scoresHuman immunodeficiency virus-1Energy X-ray absorptiometryAdvanced HIV stageAge-adjusted percentileIndependent risk factorGender-adjusted z-scoresWeight z-scorePregnancy Increases BMI in Adolescents of a Population-Based Birth Cohort 1 2
Fawzi W, Msamanga G, Spiegelman D, Hunter DJ. Pregnancy Increases BMI in Adolescents of a Population-Based Birth Cohort 1 2. Journal Of Nutrition 2005, 135: 938-944. PMID: 15795466, DOI: 10.1093/jn/135.4.938.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyMultivitamin supplementsPregnant womenHIV-negative pregnant womenDaily multivitamin supplementEarly childhood infectionsAdverse pregnancy outcomesHIV disease progressionHIV-1 infectionAdequate dietary intakeEfficacy of vitaminAdverse health outcomesFurther studiesLow-cost interventionMo of ageUninfected childrenHIV diseasePregnancy outcomesPregnant HIVHIV infectionChildhood infectionsRandomized trialsNutritional interventionDietary intakeDisease progression
2004
A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality
Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Hertzmark E, Essex M, Hunter DJ. A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality. New England Journal Of Medicine 2004, 351: 23-32. PMID: 15229304, DOI: 10.1056/nejmoa040541.Peer-Reviewed Original ResearchConceptsVitamin AHIV diseaseMultivitamin supplementsHuman immunodeficiency virus (HIV) diseasePlacebo-controlled trialHIV disease progressionStage 4 diseaseLow viral loadHigher CD4Antiretroviral therapyPrimary outcomeImmunodeficiency syndromeRandomized trialsViral loadPregnant womenDisease progressionRelative riskObservational studyDaily supplementCell countEnd pointMicronutrient statusMultivitaminsDiseaseProgressionEffect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation
Fawzi W, Msamanga G, Antelman G, Xu C, Hertzmark E, Spiegelman D, Hunter D, Anderson D. Effect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation. Clinical Infectious Diseases 2004, 38: 716-722. PMID: 14986257, DOI: 10.1086/381673.Peer-Reviewed Original ResearchConceptsHIV-1HIV-1-infected pregnant womenVitamin AHIV-1-infected womenType 1Human immunodeficiency virus type 1Immunodeficiency virus type 1Genital HIV-1Prenatal multivitamin supplementsHIV-1 transmissionCervicovaginal lavage specimensHIV Type 1HIV-1 infectionLower genital tractWeeks of gestationPrenatal vitamin supplementationUse of vitaminsVirus type 1Lack of effectPregnancy outcomesVaginal inflammationViral sheddingVitamin supplementationMultivitamin supplementsPregnant women
2003
Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts
Fawzi WW, Msamanga GI, Wei R, Spiegelman D, Antelman G, Villamor E, Manji K, Hunter D. Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts. Clinical Infectious Diseases 2003, 36: 1053-1062. PMID: 12684919, DOI: 10.1086/374223.Peer-Reviewed Original ResearchConceptsMultivitamin armCell countVitamin AHuman immunodeficiency virus type 1Immunodeficiency virus type 1Placebo-controlled trialCells/microLHIV-negative childrenHIV-positive childrenHuman immunodeficiency virusChildren of womenRapid respiratory rateVirus type 1Low-cost interventionEffect of supplementationMaternal receiptMean CD4Immunodeficiency virusMultivitamin supplementsChild morbidityChild healthVitamin supplementsLower riskRespiratory rateType 1Pattern and Predictors of Weight Gain During Pregnancy Among HIV-1–Infected Women from Tanzania
Villamor E, Msamanga G, Spiegelman D, Peterson KE, Antelman G, Fawzi WW. Pattern and Predictors of Weight Gain During Pregnancy Among HIV-1–Infected Women from Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 560-569. PMID: 12679710, DOI: 10.1097/00126334-200304150-00015.Peer-Reviewed Original ResearchMeSH KeywordsArmBody Mass IndexCohort StudiesFemaleHIV InfectionsHIV-1HumansMalaria, FalciparumNutritional StatusPredictive Value of TestsPregnancyPregnancy Complications, InfectiousPregnancy Complications, ParasiticPregnancy Trimester, SecondPregnancy Trimester, ThirdTanzaniaVitamin AVitaminsWeight GainConceptsMid-upper arm circumferenceGestational weight gainWeight gainHIV diseaseThird trimesterLower baseline CD4 T cell countsBaseline CD4 T-cell countHIV-1-infected womenCD4 T-cell countLow serum retinolT-cell countsFirst prenatal visitHIV-positive womenAdvanced clinical stageMonthly anthropometric measurementsNeonatal outcomesPrenatal visitWeek 12Clinical stagePregnant womenSecond trimesterArm circumferenceMalaria infectionSerum retinolHelminthic infections
2002
Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3
Villamor E, Msamanga G, Spiegelman D, Antelman G, Peterson KE, Hunter DJ, Fawzi WW. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1082-1090. PMID: 12399282, DOI: 10.1093/ajcn/76.5.1082.Peer-Reviewed Original ResearchConceptsEffects of multivitaminsThird trimesterWeight gainVitamin AMultivitamin supplementationSecond trimesterHIV-1-positive womenAdverse pregnancy outcomesPlacebo-controlled trialGestational weight gainHIV-positive womenEnd of pregnancyPregnancy outcomesOral supplementsAverage weight gainProtective effectTrimesterLower weight gainMultivitaminsPregnancyWomen 1HIVWomenDar es SalaamLower ratesTransmission of HIV-1 Through Breastfeeding Among Women in Dar es Salaam, Tanzania
Fawzi W, Msamanga G, Spiegelman D, Renjifo B, Bang H, Kapiga S, Coley J, Hertzmark E, Essex M, Hunter D. Transmission of HIV-1 Through Breastfeeding Among Women in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 331-338. PMID: 12439210, DOI: 10.1097/00126334-200211010-00010.Peer-Reviewed Original ResearchConceptsHIV-1High maternal viral loadLow CD4 cell countsMultivariate proportional hazards modelMaternal viral loadCD4 cell countHIV-1 transmissionErythrocyte sedimentation rateAge 6 weeksAge 4 monthsChildren of womenProportional hazards modelDar es SalaamAge 24 monthsAnalysis of correlatesNipple cracksChild transmissionImmune reconstitutionCumulative incidenceViral loadPregnant womenAntiretroviral drugsMean durationMicronutrient supplementsHigh riskRandomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality
Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, Manji K, Kapiga S, Mwakagile D, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002, 16: 1935-1944. PMID: 12351954, DOI: 10.1097/00002030-200209270-00011.Peer-Reviewed Original ResearchConceptsHIV-1 transmissionInfants of mothersVitamin ALower baseline lymphocyte countsHigh erythrocyte sedimentation rateChild mortalityBaseline lymphocyte countMaternal micronutrient statusHIV-free survivalErythrocyte sedimentation rateLow birthweight babiesEarly child mortalityRisk of transmissionLymphocyte countLower hemoglobinMultivitamin supplementationWeeks' gestationBirthweight babiesPregnant womenHIV-1Vitamin supplementsMultivitaminsNutritional statusMicronutrient statusMortalityVitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Speizer FE, Willett WC. Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States). Cancer Causes & Control 2002, 13: 221-230. PMID: 12020103, DOI: 10.1023/a:1015036317596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAscorbic AcidCarcinoma, Basal CellCarotenoidsCohort StudiesConfidence IntervalsDietDietary SupplementsFemaleHumansIncidenceLogistic ModelsMiddle AgedProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificitySkin NeoplasmsUnited StatesVitamin AVitamin EVitaminsConceptsBasal cell carcinomaVitamin ACell carcinomaDietary intakeRelative riskSun sensitivity factorsMultivariate relative riskFood frequency questionnaireRisk of BCCSignificant inverse associationIncidence of BCCImportant protective roleFirst diagnosisDietary factorsInverse associationSun exposureLatency periodProtective roleSpecific carotenoidsLogistic regressionVitamin CBottom quintileIntakeCarcinomaRiskNutrient intake and body weight in a large HIV cohort that includes women and minorities
WOODS MN, SPIEGELMAN D, Knox TA, FORRESTER JE, CONNORS JL, SKINNER SC, Silva M, KIM JH, GORBACH SL. Nutrient intake and body weight in a large HIV cohort that includes women and minorities. Journal Of The Academy Of Nutrition And Dietetics 2002, 102: 203-211. PMID: 11846114, DOI: 10.1016/s0002-8223(02)90049-0.Peer-Reviewed Original ResearchConceptsVitamin/mineral supplementsNutrient intakeMicronutrient intakeBaseline nutrient intakeLarge HIV cohortCD4 cell countCD4 lymphocyte countHIV-positive populationBody mass indexInadequate nutrient intakeStudy sampleNHANES III dataWilcoxon rank sum testCubic spline modelsMineral supplementsRank sum testHIV cohortLymphocyte countSpearman correlation coefficientMass indexProspective studyFood recordsMedian intakeDietary intakeNutritional intake
2000
Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-254. DOI: 10.1097/00042560-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusBackground Observational studiesMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmRandomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania.
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-54. PMID: 10839660, DOI: 10.1097/00126334-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmStatus
1999
Rationale and Design of the Tanzania Vitamin and HIV Infection Trial
Fawzi W, Msamanga G, Spiegelman D, Urassa E, Hunter D. Rationale and Design of the Tanzania Vitamin and HIV Infection Trial. Contemporary Clinical Trials 1999, 20: 75-90. PMID: 10027501, DOI: 10.1016/s0197-2456(98)00045-2.Peer-Reviewed Original ResearchConceptsHIV infectionVitamin APregnant womenPolymerase chain reactionVitamin supplementsHIV-positive pregnant womenVertical transmissionHIV Infection TrialInfant immune functionEligible pregnant womenPlacebo-controlled trialClinical staging systemHIV-positive womenGenital tract secretionsUse of supplementsHIV diseaseMost HIVPrevention trialsViral loadMain endpointBreast milkStaging systemCohort retentionPosttest counselingTract secretions
1998
Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania
Fawzi W, Msamanga G, Spiegelman D, Urassa E, McGrath N, Mwakagile D, Antelman G, Mbise R, Kapiga S, Willett W, Hunter D, Team F, Herrera G. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet 1998, 351: 1477-1482. PMID: 9605804, DOI: 10.1016/s0140-6736(98)04197-x.Peer-Reviewed Original ResearchConceptsHIV-1-infected womenT-cell countsHIV-1 diseaseBirth outcomesVitamin APregnancy outcomesMultivitamin supplementationHIV-1-infected pregnant womenPoor micronutrient statusTrial of effectAdverse pregnancy outcomesPlacebo-controlled trialT lymphocyte subsetsAdverse birth outcomesEffects of multivitaminsSevere preterm birthsLymphocyte subsetsPreterm birthFetal deathWeeks' gestationGestational ageClinical progressionPregnant womenLow birthweightFaster progression