A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.
Hunter DJ, Hankinson SE, Hough H, Gertig DM, Garcia-Closas M, Spiegelman D, Manson JE, Colditz GA, Willett WC, Speizer FE, Kelsey K. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis 1997, 18: 2127-2132. PMID: 9395212, DOI: 10.1093/carcin/18.11.2127.Peer-Reviewed Original ResearchConceptsRapid acetylatorsBreast cancerSlow acetylatorsCigarette smokingProspective studyFast acetylatorsNAT2 genotypeRelative riskFast NAT2 acetylatorsNAT2 acetylation genotypeMultivariate relative riskPost-menopausal womenBreast cancer riskNAT2 acetylation statusCase-control studyNon-significant elevationN-acetyltransferase 2 geneAcetylation genotypeNever smokersCurrent smokersCurrent smokingNAT2 acetylatorsFirst pregnancyIncident casesSignificant elevation