Testing gene–environment interactions in the presence of confounders and mismeasured environmental exposures
Cheng C, Spiegelman D, Wang Z, Wang M. Testing gene–environment interactions in the presence of confounders and mismeasured environmental exposures. G3: Genes, Genomes, Genetics 2021, 11: jkab236. PMID: 34568916, PMCID: PMC8473983, DOI: 10.1093/g3journal/jkab236.Peer-Reviewed Original ResearchConceptsStandard logistic regression approachGreater statistical powerStatistical powerBinary disease outcomeComputational efficiencyIllustrative exampleComputation timeExtensive simulation experimentsMost simulation scenariosMeasurement errorRegression approachConsideration adjustmentsSimulation experimentsExposure measurement errorReverse testLogistic regression approachSimulation scenariosLinear discriminant analysisApproachReverse approachPowerErrorDiscriminant analysis