2001
Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
Chu N, Spiegelman D, Hotamisligil G, Rifai N, Stampfer M, Rimm E. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 2001, 157: 495-503. PMID: 11472752, DOI: 10.1016/s0021-9150(00)00755-3.Peer-Reviewed Original ResearchConceptsCVD risk factorsRisk factorsPlasma insulinCVD riskHDL cholesterolInsulin levelsPlasma leptinAntigen levelsSoluble TNF receptor levelsCardiovascular disease risk factorsTissue plasminogen activator antigen levelsT-PA antigen levelsMetabolic cardiovascular syndromeHealth Professionals FollowIndependent risk factorDisease risk factorsEffect of obesitySoluble TNF receptorsTNF receptor levelsCardiovascular disease morbidityBody mass indexLevels of insulinProfessionals FollowLeptin levelsMass indexPlasma leptin concentrations and four-year weight gain among US men
Chu N, Spiegelman D, Yu J, Rifai N, Hotamisligil G, Rimm E. Plasma leptin concentrations and four-year weight gain among US men. International Journal Of Obesity 2001, 25: 346-353. PMID: 11319631, DOI: 10.1038/sj.ijo.0801549.Peer-Reviewed Original ResearchConceptsPlasma leptin concentrationsBaseline body mass indexPlasma leptin levelsLeptin levelsSubsequent weight gainLeptin concentrationsWeight gainInsulin levelsLeptin resistanceUS menSoluble tumor necrosis factor receptor levelsTumor necrosis factor receptor levelsBaseline plasma leptin levelsElevated plasma leptin concentrationsFour-year prospective studyDetailed lifestyle questionnaireHigher baseline leptinHealth Professionals FollowBody mass indexTotal energy intakeBody fat massPlasma insulin levelsDevelopment of obesityFollow-up questionnaireBaseline leptin
2000
Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk
Fung TT, Hu FB, Yu J, Chu NF, Spiegelman D, Tofler GH, Willett WC, Rimm EB. Leisure-Time Physical Activity, Television Watching, and Plasma Biomarkers of Obesity and Cardiovascular Disease Risk. American Journal Of Epidemiology 2000, 152: 1171-1178. PMID: 11130623, DOI: 10.1093/aje/152.12.1171.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityDensity lipoprotein cholesterolPhysical activityCVD riskLipoprotein cholesterolHDL cholesterolCardiovascular diseaseTelevision watchingLong-term leisure-time physical activityHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolLong-term physical activityMale health professionalsBiomarkers of obesityCardiovascular disease riskBlood lipidsThrombogenic factorsLeptin levelsInsulin sensitivityC-peptideApolipoprotein A1Vigorous activityLinear regression analysisBiochemical markersHealth professionalsGlycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men
Chu N, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men. International Journal Of Obesity 2000, 24: 1085-1092. PMID: 11033975, DOI: 10.1038/sj.ijo.0801361.Peer-Reviewed Original ResearchConceptsPlasma leptinSTNF-R1C-peptideOverweight menGlycemic statusLeptin concentrationsGlucose homeostasisSoluble tumor necrosis factor receptor levelsSoluble tumour necrosis factor receptor concentrationsTumor necrosis factor receptor levelsDetailed lifestyle questionnaireSTNF-R2 concentrationsHealth Professionals FollowBody mass indexPlasma leptin levelsObesity-related disordersAdipose-derived cytokineCross-sectional studyConsiderable inter-individual variationProfessionals FollowDiabetes mellitusLeptin levelsMass indexNormal weightHighest quintile