2022
Design and Implementation of a Culturally-Tailored Randomized Pilot Trial: Puerto Rican Optimized Mediterranean-Like Diet
Mattei J, Díaz-Alvarez C, Alfonso C, O’Neill H, Ríos-Bedoya C, Malik V, Godoy-Vitorino F, Cheng C, Spiegelman D, Willett W, Hu F, Rodríguez-Orengo J. Design and Implementation of a Culturally-Tailored Randomized Pilot Trial: Puerto Rican Optimized Mediterranean-Like Diet. Current Developments In Nutrition 2022, 7: 100022. PMID: 37181130, PMCID: PMC10100940, DOI: 10.1016/j.cdnut.2022.100022.Peer-Reviewed Original ResearchMediterranean-like dietNutritional counseling sessionsPilot trialHealthier cardiometabolic profileIndividual cardiometabolic factorsCardiometabolic risk factorsRandomized pilot trialDisease prevention programsCounseling sessionsDaily text messagesFree-living adultsCardiometabolic factorsCardiometabolic profileCardiometabolic healthSecondary outcomesPrimary outcomeRisk factorsDietary intakeIntervention groupChronic diseasesTwo-armOutcome measuresHigh riskMediterranean dietPsychosocial factors
2013
Dietary Patterns, Nutrient Intake, and Sociodemographic Characteristics in HIV-Infected Tanzanian Pregnant Women
Lukmanji Z, Hertzmark E, Spiegleman D, Fawzi WW. Dietary Patterns, Nutrient Intake, and Sociodemographic Characteristics in HIV-Infected Tanzanian Pregnant Women. Ecology Of Food And Nutrition 2013, 52: 34-62. PMID: 23282190, DOI: 10.1080/03670244.2012.705768.Peer-Reviewed Original ResearchConceptsPregnant womenNutrient intakeTanzanian pregnant womenWorld Health Organization recommendationsDietary macronutrient intakeLongitudinal clinical trialsVitamin supplementationClinical trialsDietary intakeMacronutrient intakeDietary patternsDiet intakeFood composition tablesHigh riskWomen's ageSociodemographic characteristicsIntakeInadequate foodDar es SalaamWomenHIVTwo-thirdsEducation levelComposition tablesAge
2012
Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors
Nagu T, Kanyangarara M, Hawkins C, Hertmark E, Chalamila G, Spiegelman D, Mugusi F, Fawzi W. Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors. HIV Medicine 2012, 13: 541-548. PMID: 22416813, PMCID: PMC3391335, DOI: 10.1111/j.1468-1293.2012.01006.x.Peer-Reviewed Original ResearchConceptsElevated alanine aminotransferaseIU/LAlanine aminotransferaseAntiretroviral therapyHigh riskWorld Health Organization clinical stageCD4 T-lymphocyte countFirst-line antiretroviral therapyHepatitis B virus coinfectionALT measurementsLow-density lipoprotein cholesterolLog-binomial regression modelsB virus coinfectionT-lymphocyte countsART-naïve HIVCells/μLHepatotoxic side effectsCurrent tuberculosis (TB) treatmentResource-limited settingsCross-sectional analysisAdvanced immunosuppressionHBV coinfectionART-naïveHIV careLipoprotein cholesterol
2011
Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. American Journal Of Clinical Nutrition 2011, 94: 431-438. PMID: 21697077, PMCID: PMC3142722, DOI: 10.3945/ajcn.111.012054.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNonfatal myocardial infarctionSudden cardiac arrestFatal coronary heart diseaseTotal coronary heart diseaseIncident coronary heart diseaseDe novo lipogenesisHigh riskCHD eventsHeart diseaseMultivariable-adjusted Cox proportional hazardsCommunity-based prospective studySecondary analysisCardiovascular disease risk factorsCardiovascular Health StudyDisease risk factorsFatty acidsCox proportional hazardsDe novo lipogenesis pathwayCHD deathCHD outcomesProspective studyCardiac arrestMyocardial infarctionMedical records
2003
Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women
Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC. Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women. American Journal Of Epidemiology 2003, 158: 760-771. PMID: 14561666, DOI: 10.1093/aje/kwg221.Peer-Reviewed Original ResearchConceptsMajor chronic diseasesFolate intakeChronic diseasesCardiovascular diseaseLower total folate intakeJoint associationsMultivariate relative riskNonfatal cardiovascular diseaseTotal folate intakeHigh folate intakeAdequate folate intakeAge 60 yearsLow folate intakePrimary preventionNontraumatic deathsRelative riskHigh riskPrevious historyDietary dataHeavy drinkersNew casesYoung womenDiseaseHeavy drinkingIntake
2002
Transmission of HIV-1 Through Breastfeeding Among Women in Dar es Salaam, Tanzania
Fawzi W, Msamanga G, Spiegelman D, Renjifo B, Bang H, Kapiga S, Coley J, Hertzmark E, Essex M, Hunter D. Transmission of HIV-1 Through Breastfeeding Among Women in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 331-338. PMID: 12439210, DOI: 10.1097/00126334-200211010-00010.Peer-Reviewed Original ResearchConceptsHIV-1High maternal viral loadLow CD4 cell countsMultivariate proportional hazards modelMaternal viral loadCD4 cell countHIV-1 transmissionErythrocyte sedimentation rateAge 6 weeksAge 4 monthsChildren of womenProportional hazards modelDar es SalaamAge 24 monthsAnalysis of correlatesNipple cracksChild transmissionImmune reconstitutionCumulative incidenceViral loadPregnant womenAntiretroviral drugsMean durationMicronutrient supplementsHigh risk
2001
The association between maternal HIV‐1 infection and pregnancy outcomes in Dar es Salaam, Tanzania
Coley J, Msamanga G, Fawzi M, Kaaya S, Hertzmark E, Kapiga S, Spiegelman D, Hunter D, Fawzi W. The association between maternal HIV‐1 infection and pregnancy outcomes in Dar es Salaam, Tanzania. BJOG An International Journal Of Obstetrics & Gynaecology 2001, 108: 1125-1133. PMID: 11762650, PMCID: PMC6276363, DOI: 10.1111/j.1471-0528.2003.00269.x.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesPregnancy outcomesSymptomatic HIVLow birthweightPregnant womenHigh riskMaternal HIV-1 infectionMaternal HIV infectionCohort of HIVProspective cohort studyHIV-1 infectionWeeks of gestationPotential confounding factorsDar es SalaamCohort studyHIV infectionGestational ageImmature infantsFetal lossHead circumferenceHIVConfounding factorsWomenOutcomesSignificant differencesThe association between maternal HIV-1 infection and pregnancy outcomes in Dar es Salaam, Tanzania
Coley J, Msamanga G, Fawzi M, Kaaya S, Hertzmark E, Kapiga S, Spiegelman D, Hunter D, Fawzi W. The association between maternal HIV-1 infection and pregnancy outcomes in Dar es Salaam, Tanzania. BJOG An International Journal Of Obstetrics & Gynaecology 2001, 108: 1125-1133. DOI: 10.1016/s0306-5456(01)00269-8.Peer-Reviewed Original ResearchAdverse pregnancy outcomesPregnancy outcomesSymptomatic HIVLow birthweightPregnant womenHigh riskMaternal HIV-1 infectionMaternal HIV infectionCohort of HIVHIV-1 infectionWeeks of gestationPotential confounding factorsDar es SalaamConclusion HIVHIV infectionGestational ageImmature infantsFetal lossHead circumferenceHIVConfounding factorsWomenOutcomesSignificant differencesBirthweight
2000
Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania
Fawzi W, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. The Journal Of Pediatrics 2000, 137: 660-667. PMID: 11060532, DOI: 10.1067/mpd.2000.110136.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsHuman immunodeficiency virusTract infectionsVitamin APlacebo-controlled trialAcute respiratory infectionsSevere watery diarrheaRisk of diarrheaEffect of vitaminDuration of episodesRapid respiratory rateLow-cost interventionAcute diarrheaRespiratory infectionsImmunodeficiency virusWatery diarrheaAdverse outcomesUndernourished childrenHigh riskDiarrheaRespiratory rateInfectionSmall riskPlaceboDar es SalaamRandomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-254. DOI: 10.1097/00042560-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusBackground Observational studiesMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmRandomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania.
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-54. PMID: 10839660, DOI: 10.1097/00126334-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmStatusRandomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-254. DOI: 10.1097/00126334-200003010-00005.Peer-Reviewed Original ResearchPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmStatus
1999
Smoking and risk of total and fatal prostate cancer in United States health professionals.
Giovannucci E, Rimm EB, Ascherio A, Colditz GA, Spiegelman D, Stampfer MJ, Willett WC. Smoking and risk of total and fatal prostate cancer in United States health professionals. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 277-82. PMID: 10207628.Peer-Reviewed Original ResearchConceptsFatal prostate cancerProstate cancerCancer incidenceHealth professionalsCumulative smoking historyMale health professionalsSmoking-related comorbiditiesTotal prostate cancerDistant metastatic diseaseProstate cancer incidenceMetastatic prostate cancerRecent tobacco useMetastatic diseaseSmoking historyCigarette smokingLifestyle factorsExcess riskFatal casesTobacco useHigh riskScreening behaviorSmokingCigarette useCancerSmokers
1998
The relation of physical activity to risk for symptomatic gallstone disease in men.
Leitzmann MF, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Wing AL, Willett WC. The relation of physical activity to risk for symptomatic gallstone disease in men. Annals Of Internal Medicine 1998, 128: 417-25. PMID: 9499324, DOI: 10.7326/0003-4819-128-6-199803150-00001.Peer-Reviewed Original ResearchConceptsSymptomatic gallstone diseaseGallstone diseasePhysical activityYears of ageSymptomatic gallstonesBody weightU.S. male health professionalsMale health professionalsProspective cohort studyUse of medicationsMen 65 yearsStrong inverse associationBiliary eventsMen 40Cohort studySmoking habitsExtreme quintilesAlcohol intakeRecent symptomsInverse associationMultiple confoundersMedical conditionsSedentary behaviorHigh riskHealth professionals
1997
A prospective study of malnutrition in relation to child mortality in the Sudan
Fawzi W, Herrera, Spiegelman D, Amin A, Nestel P, Mohamed K. A prospective study of malnutrition in relation to child mortality in the Sudan. American Journal Of Clinical Nutrition 1997, 65: 1062-1069. PMID: 9094894, DOI: 10.1093/ajcn/65.4.1062.Peer-Reviewed Original Research