2024
Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationshipNeural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2010
Sex differences in neural responses to stress and alcohol context cues
Seo D, Jia Z, Lacadie CM, Tsou KA, Bergquist K, Sinha R. Sex differences in neural responses to stress and alcohol context cues. Human Brain Mapping 2010, 32: 1998-2013. PMID: 21162046, PMCID: PMC3236497, DOI: 10.1002/hbm.21165.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexMedial prefrontal cortexRostral anterior cingulate cortexAlcohol cue exposureOrbitofrontal cortexContext cuesNeural responsesFunctional magnetic resonance imagingSex differencesVentral striatum activityLeft dorsal striatumMiddle frontal gyrusMedial orbitofrontal cortexAlcohol-related behaviorsStress-related activationCognitive processingVentromedial PFCNeural correlatesSex-specific vulnerabilityNeural processingPersonalized stressStriatum activityAnterior insulaBrain responsesFrontal gyrus