pHLIP targeted intracellular delivery of calicheamicin
DuPont M, Klumpp C, Iraca M, Allababidi D, Visca H, Engelman D, Andreev O, Moshnikova A, Reshetnyak Y. pHLIP targeted intracellular delivery of calicheamicin. International Journal Of Pharmaceutics 2024, 654: 123954. PMID: 38428548, DOI: 10.1016/j.ijpharm.2024.123954.Peer-Reviewed Original ResearchM2 tumor-associated macrophagesTreatment of solid tumorsTumor-associated macrophagesTherapeutic agents to tumorsTumor-stroma interfaceAgents to tumorsInhibited tumor growthPolarized M2 macrophagesTreatment of tumorsAntibody-drug conjugatesTumor massLiquid tumorsSolid tumorsImmune cellsTumor growthM2 macrophagesTumorPH low insertion peptideBiodistribution studiesIntracellular deliveryIn vivoTumor coreCalicheamicinMacrophagesTreatment