Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides
Reshetnyak Y, Andreev O, Engelman D. Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides. Frontiers In Pharmacology 2024, 15: 1355893. PMID: 38545547, PMCID: PMC10965573, DOI: 10.3389/fphar.2024.1355893.Peer-Reviewed Original ResearchTumor microenvironmentTherapeutic agents to solid tumorsTargeted intracellular deliverySolid tumorsImmune cellsPHLIP technologyTargeted delivery of imagingPre-clinicalDelivery of imagingTherapeutic payloadsTumorTargeted deliveryIntracellular deliveryTumor imagingSimultaneous targetingClinical applicationTherapeutic deliveryCell typesSurface of cellsPHLIP peptidePHLIPDeliveryTarget biomarkersCellsMagic bulletTargeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors
Moshnikova A, DuPont M, Iraca M, Klumpp C, Visca H, Allababidi D, Pelzer P, Engelman D, Andreev O, Reshetnyak Y. Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors. Frontiers In Pharmacology 2024, 15: 1346756. PMID: 38495104, PMCID: PMC10940318, DOI: 10.3389/fphar.2024.1346756.Peer-Reviewed Original ResearchTargeted intracellular deliveryIntracellular deliveryTreatment of solid tumorsAnti-cancer immunityPHLIP peptideBinding to plasma proteinsBlood half-lifeTumor eradicationSolid tumorsCytokine activityTumorTargeted deliveryDelivery approachesHalf-lifePlasma proteinsDMSAPHLIPDeliveryMembrane lipid bilayerPeptide