Synthetic Host–Guest Assembly in Cells and Tissues: Fast, Stable, and Selective Bioorthogonal Imaging via Molecular Recognition
Sasmal R, Saha N, Pahwa M, Rao S, Joshi D, Inamdar M, Sheeba V, Agasti S. Synthetic Host–Guest Assembly in Cells and Tissues: Fast, Stable, and Selective Bioorthogonal Imaging via Molecular Recognition. Analytical Chemistry 2018, 90: 11305-11314. PMID: 30148612, PMCID: PMC6569623, DOI: 10.1021/acs.analchem.8b01851.Peer-Reviewed Original ResearchConceptsBioorthogonal strategiesBioorthogonal imagingNoncovalent interactionsCovalent reactionSynthetic host-guest systemsHost-guest assemblyHost-guest interactionsHost-guest systemsNoncovalent approachMolecular recognitionLack of selectivityBioorthogonal labelingNoncovalent mechanismsBalanced reactivitySensitive detectionAssembly strategyLabeling agentNew analytical toolsLiving cellsAnalytical toolsReactionCellular environmentStabilitySelectivityFluorophores