2023
Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression
Jiang H, Ambrose N, Chung C, Wang Y, Söll D, Tharp J. Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2219758120. PMID: 36787361, PMCID: PMC9974479, DOI: 10.1073/pnas.2219758120.Peer-Reviewed Original ResearchConceptsAminoacyl-tRNA synthetasesCodon suppressionStop codon suppressionGene expressionOrthogonal aminoacyl-tRNA synthetasesRelevant protein-protein interactionsSynthetic biology toolsSmall molecule rapamycinControl gene expressionProtein-protein interactionsLevel of transcriptionAbscisic acidDimerization domainMammalian cellsBiology toolsGene translationTranslational levelMolecular switchStop codonHuman cellsMolecular inputsUseful biotechnologySynthetasesExpressionTherapeutic applications
1993
Incomplete citric acid cycle obliges aminolevulinic acid synthesis via the C5 pathway in a methylotroph
Lloyd A, Weitzman P, Söll D. Incomplete citric acid cycle obliges aminolevulinic acid synthesis via the C5 pathway in a methylotroph. Microbiology 1993, 139: 2931-2938. DOI: 10.1099/00221287-139-12-2931.Peer-Reviewed Original ResearchC5 pathwayM. methylotrophusAminolevulinic acid synthesisTRNA-dependent mannerConversion of pyruvateCitric acid cycleMalate dehydrogenase activityMammalian cellsGlyoxylate cycleALA formationCell-free extractsGlu-tRNAGluAcid cycleIsocitrate dehydrogenaseMethylophilus methylotrophusCatabolic roleAcid synthesisPathwayEnzymic activityDehydrogenase activityEnzymeConnected pathwaysAlaMethylotrophsYeast
1991
Transfer RNA Involvement in Chlorophyll Biosynthesis
O’Neill G, Jahn D, Söll D. Transfer RNA Involvement in Chlorophyll Biosynthesis. Subcellular Biochemistry 1991, 17: 235-264. PMID: 1796486, DOI: 10.1007/978-1-4613-9365-8_11.Peer-Reviewed Original ResearchConceptsTransfer RNARegulation of hemeBranched biosynthetic pathwayPorphyrin biosynthesisBiosynthesis of ALAPhotosynthetic metabolismChlorophyll biosynthesisRNA involvementArchaebacterial kingdomMammalian cellsBiosynthetic pathwayChlorophyll synthesisBacterial systemsBiosynthesisRecent rapid progressPlantsCentral roleAlaHemeTetrapyrrole ringEnzymePathwayFive-carbonProkaryotesExperimental system
1974
15. Aminoacyl-tRNA Synthetases
Söll D, Schimmel P. 15. Aminoacyl-tRNA Synthetases. The Enzymes 1974, 10: 489-538. DOI: 10.1016/s1874-6047(08)60147-x.Peer-Reviewed Original ResearchAminoacyl-tRNA synthetasesEucaryotic organismsSpecific aminoacyl-tRNA synthetasesCorresponding cytoplasmic enzymesFamily of enzymesMitochondrial tRNAsProtein biosynthesisMammalian cellsMammalian virusesSynthetasesCytoplasmic enzymeSeparate proteinsCell extractsTRNAAmino acidsOrganismsCytoplasmSame organismEnzymeOrganellesMitochondriaMachineryProteinKey roleProcaryotes