1987
Allele-specific complementation of an Escherichia coli leuB mutation by a Lactobacillus bulgaricus tRNA gene
Hottinger H, Ohgi T, Zwahlen M, Dhamija S, Söll D. Allele-specific complementation of an Escherichia coli leuB mutation by a Lactobacillus bulgaricus tRNA gene. Gene 1987, 60: 75-83. PMID: 3326787, DOI: 10.1016/0378-1119(87)90215-0.Peer-Reviewed Original ResearchConceptsTRNA genesCopy numberWild-type formE. coli promotersHigh copy numberGene copy numberLeuB mutationClone bankLeucine prototrophyLow copy numberMissense suppressionNucleotide sequenceSerine tRNATerminator elementsGenesRestoration of activityTRNAEscherichia coliAmino acidsGene allelesExtra armE. coli
1984
Mutations affecting excision of the intron from a eukaryotic dimeric tRNA precursor.
Willis I, Hottinger H, Pearson D, Chisholm V, Leupold U, Söll D. Mutations affecting excision of the intron from a eukaryotic dimeric tRNA precursor. The EMBO Journal 1984, 3: 1573-1580. PMID: 6430697, PMCID: PMC557561, DOI: 10.1002/j.1460-2075.1984.tb02013.x.Peer-Reviewed Original ResearchConceptsTRNA precursorsDimeric tRNA precursorSerine tRNA geneEfficiency of splicingPrecursor tRNA processingSingle base changeTRNA genesTRNASer geneTRNA processingGene transcriptionNucleotide sequenceUGA mutationsD-loopMutant geneGenesBase changesExtra armMutationsIntronsTranscriptionVivo systemDimeric precursorSequenceTRNASerSplicing