M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance
Galvin VC, Yang S, Lowet AS, Datta D, Duque A, Arnsten AF, Wang M. M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance. Current Research In Neurobiology 2021, 2: 100016. PMID: 35098156, PMCID: PMC8794314, DOI: 10.1016/j.crneur.2021.100016.Peer-Reviewed Original ResearchNicotinic α7 receptorsMemory performanceMemory taskNMDA receptorsSingle neuron activityMemory circuitryDLPFCPrimate dlPFCΑ7 receptorsM1 receptorsCognitive disordersDLPFC circuitryPermissive actionPersistent activityGlutamatergic NMDA receptorsNMDAR dysfunctionMemoryNMDAR blockadeMuscarinic M1 receptorsTreatment of schizophreniaRecurrent excitatory circuitsPositive allosteric modulatorsNMDA applicationExcitatory circuitsNeuronal activity