2021
M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance
Galvin VC, Yang S, Lowet AS, Datta D, Duque A, Arnsten AF, Wang M. M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance. Current Research In Neurobiology 2021, 2: 100016. PMID: 35098156, PMCID: PMC8794314, DOI: 10.1016/j.crneur.2021.100016.Peer-Reviewed Original ResearchNicotinic α7 receptorsMemory performanceMemory taskNMDA receptorsSingle neuron activityMemory circuitryDLPFCPrimate dlPFCΑ7 receptorsM1 receptorsCognitive disordersDLPFC circuitryPermissive actionPersistent activityGlutamatergic NMDA receptorsNMDAR dysfunctionMemoryNMDAR blockadeMuscarinic M1 receptorsTreatment of schizophreniaRecurrent excitatory circuitsPositive allosteric modulatorsNMDA applicationExcitatory circuitsNeuronal activity
2016
Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia
Hoftman G, Datta D, Lewis D. Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia. Biological Psychiatry 2016, 81: 862-873. PMID: 27455897, PMCID: PMC5136518, DOI: 10.1016/j.biopsych.2016.05.022.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexInhibitory gamma-aminobutyric acid (GABA) neuronsGamma-aminobutyric acid (GABA) neuronsPrefrontal cortexCertain clinical featuresExcitatory pyramidal neuronsAdverse environmental exposuresDisorders of neurodevelopmentNature of schizophreniaDLPFC circuitryInhibitory circuitryClinical featuresPyramidal neuronsDisease processDevelopmental refinementMemory impairmentMemory alterationsDevelopmental disturbancesNeural circuitrySchizophreniaEnvironmental exposuresLate developmental processesNeurodevelopmental disordersSpecific populationsAlterations