Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease
Oh U, McCormick M, Datta D, Turner R, Bobb K, Monie D, Sliskovic D, Tanaka Y, Zhang J, Meshulam J, Jacobson S. Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease. Blood 2011, 117: 3363-3369. PMID: 21212284, PMCID: PMC3069676, DOI: 10.1182/blood-2010-10-306571.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsHAM/TSPNF-κB activationImmune activationHuman T-lymphotropic virus type IMyelopathy/tropical spastic paraparesisNuclear factor-kappa B (NF-κB) inhibitorChronic inflammatory disordersBlood mononuclear cellsLymphocyte activation markersTropical spastic paraparesisCentral nervous systemNF-κB pathwayNF-κB inhibitionNovel small molecule inhibitorVirus type ICanonical NF-κB activationViral protein expressionSpontaneous lymphoproliferationShort-term cultureActivation markersInflammatory disordersMononuclear cellsSpastic paraparesisNeurologic disease