2013
PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice
Li H, Park D, Abdul-Muneer P, Xu B, Wang H, Xing B, Wu D, Li S. PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience 2013, 253: 89-99. PMID: 24012746, PMCID: PMC9529370, DOI: 10.1016/j.neuroscience.2013.08.051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCD3 ComplexClass Ib Phosphatidylinositol 3-KinaseDioxolesDisease Models, AnimalEctodysplasinsEncephalomyelitis, Autoimmune, ExperimentalEnzyme InhibitorsGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutMyelin SheathMyelin-Oligodendrocyte GlycoproteinNeurofilament ProteinsPeptide FragmentsPhosphoinositide-3 Kinase InhibitorsSerotoninSeverity of Illness IndexSpinal CordThiazolidinedionesTime FactorsConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisEAE miceSpinal cordExperimental autoimmune encephalomyelitis (EAE) miceAutoimmune CNS inflammationLumbar spinal cordNumber of axonsCNS inflammationAutoimmune encephalomyelitisSystemic treatmentClinical symptomsPI3Kγ inhibitionInflammatory cellsAxon numberClinical signsInflammatory responseInflammatory reactionKnockout miceFiber tractsMicePI3Kγ inhibitorsCordSymptomsPI3Kγ
2005
Mouse Taste Buds Use Serotonin as a Neurotransmitter
Huang Y, Maruyama Y, Lu K, Pereira E, Plonsky I, Baur J, Wu D, Roper S. Mouse Taste Buds Use Serotonin as a Neurotransmitter. Journal Of Neuroscience 2005, 25: 843-847. PMID: 15673664, PMCID: PMC6725637, DOI: 10.1523/jneurosci.4446-04.2005.Peer-Reviewed Original ResearchConceptsTaste budsPrimary sensory afferent fibersSensory afferent fibersBitter stimulationTransmitter release mechanismMouse taste budsAfferent fibersTransmitter candidatesGustatory receptor cellsIntracellular Ca2SerotoninSour tastantsReceptor cellsChinese hamster ovary cellsHamster ovary cellsNeurotransmittersSynapsesStimulationOvary cellsReleaseCa2CellsAcetylcholineCNSReceptors